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Hydrolysis of lactitol, maltitol and Palatinit® by human intestinal biopsies

Published online by Cambridge University Press:  09 March 2007

U. Nilsson  and
M. Jägerstad
U. Nilsson
Affiliation:
Department of Applied Nutrition, Chemical Center, University of Lund, Box 124, S-221 00 Lund, Sweden
M. Jägerstad
Affiliation:
Department of Applied Nutrition, Chemical Center, University of Lund, Box 124, S-221 00 Lund, Sweden
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Abstract

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1. The hydrolysis of sugar alcohols of the disaccharide type such as lactitol, maltitol and Palatinit® (the latter an equimolar mixture of 6-O-α-D-glucopyranoside-D-mannitol and 6-O-α-D-glucopyranoside-D-sorbitol) by homogenates of human intestinal biopsies were compared with corresponding natural disaccharides such as lactose, maltose and isomaltose. Seven of the human biopsies were normal with regard to their disaccharidase activities, while twelve biopsies showed decreased levels of disaccharidase activities.

2. All biopsies, normal as well as abnormal, showed essentially the same capacity to hydrolyse the sugar alcohols. Activities towards lactitol (0.34 IE/g protein (where IE = μmol disaccharide hydrolysed/min at 37°)) and Palatinit (2.50 IE/g protein) were only 1.3% of those towards lactose and isomaltose. The activity towards maltitol was much higher (19.1 IE/g protein), approximately 10% of that towards maltose and about as high as the activity towards trehalose. This finding indicates that despite the fact that lactitol and Palatinit were poor substrates, significant amounts of ingested maltitol might be digested and utilized by man.

3. Glucose release was reduced by approximately 25% when maltitol or Palatinit were present at concentrations equal to those of maltose. Palatinit decreased the hydrolysis of sucrose by 12%. Lactitol had no inhibitory effect on the hydrolysis of disaccharides.

Type
Clinical and Human Nutrition papers: Studies in Man
Information
British Journal of Nutrition , Volume 58 , Issue 2 , September 1987 , pp. 199 - 206
Copyright
Copyright © The Nutrition Society 1987

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