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Effects of saponins on bile acids and plasma lipids in the rat

Published online by Cambridge University Press:  09 March 2007

D. G. Oakenfull
Affiliation:
CSIRO Division of Food Research, PO Box 52, North Ryde, NSW 2113
Dorothy E. Fenwick
Affiliation:
CSIRO Division of Food Research, PO Box 52, North Ryde, NSW 2113
R. L. Hood
Affiliation:
CSIRO Division of Food Research, PO Box 52, North Ryde, NSW 2113
D. L. Topping
Affiliation:
CSIRO Division of Human Nutrition, Kintore Avenue, Adelaide, South Australia 5000, Australia
R. L. Illman
Affiliation:
CSIRO Division of Human Nutrition, Kintore Avenue, Adelaide, South Australia 5000, Australia
G. B. Storer
Affiliation:
CSIRO Division of Human Nutrition, Kintore Avenue, Adelaide, South Australia 5000, Australia
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Abstract

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1. The effects of feeding isolated saponins on plasma lipid concentrations and on concentrations of biliary and faecal bile acids and neutral sterols were studied in the rat.

2. The animals were given one of four diets, i.e. a standard low-cholesterol synthetic diet, the diet+10 g saponins/kg, the diet+10 g cholesterol/kg, the diet+10 g cholesterol+10 g saponins/kg.

3. Saponins partially reversed the hypercholesterolaemia caused by the high-cholesterol diet and increased both the rate of bile acid secretion and the faecal excretion of bile acids and neutral sterols. The proportionate contribution of the primary bile acids (particularly chenodeoxycholic) to faecal excretion was also increased by saponins.

4. The results are discussed in relation to the hypothesis that saponins act by inducing the adsorption of bile acids by dietary fibre.

Type
Papers of direct relevance to Clinical and Human Nutrition
Copyright
Copyright © The Nutrition Society 1979

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