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Effects of protein and vitamin E on haemoglobin formation in rats

Published online by Cambridge University Press:  09 March 2007

J. Bunyan
Affiliation:
Beecham Research Laboratories, Vitamins Research Station, Walton Oaks, Tadworth, Surrey
J. Green
Affiliation:
Beecham Research Laboratories, Vitamins Research Station, Walton Oaks, Tadworth, Surrey
M. A. Cawthorne
Affiliation:
Beecham Research Laboratories, Vitamins Research Station, Walton Oaks, Tadworth, Surrey
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Abstract

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1. Young rats were given, for 9 weeks, vitamin E-deficient diets containing either 20% or 10% casein, with and without a dietary supplement of 350 ppm D-α-tocopheryl acetate. For the next 5 weeks the casein content of the low-protein diets was decreased to 7%.

2. The low-protein diets induced severe growth depression.

3. The dialuric acid-induced haemolysis test showed that the rats given the 20% casein vitamin E-deficient diet were depleted of vitamin E, but that the rate of depletion on the lowcasein diet was slower.

4. Haemoglobin levels were slightly decreased by the 10% casein diets after 9 weeks, but this difference was not found after 14 weeks, comparing 20% and 7% casein. Dietary vitamin E had no effect on haemoglobin levels or erythrocyte counts.

Type
Research Article
Copyright
Copyright © The Nutrition Society 1968

References

Aterman, K. & Norkin, S. (1963). Fedn Proc. Fedn Am. Socs exp. Biol. 22, 602.Google Scholar
Bencze, B., Gerlóczy, F., Ugrai, E. & Kneiszl, F. (1966). Int. Z. VitamForsch. 36, 24.Google Scholar
Binder, H. J., Herting, D. C., Hurst, V., Finch, S. & Spiro, H. M. (1965). New Engl. J. Med. 273, 1289.CrossRefGoogle Scholar
Bunyan, J., Green, J., Diplock, A. T. & Robinson, D. (1967). Br. J. Nutr. 21, 137.CrossRefGoogle Scholar
Bunyan, J., Green, J., Edwin, E. E. & Diplock, A. T. (1960). Biochem. J. 75, 460.CrossRefGoogle Scholar
Dinning, J. S. (1963). Nutr. Rev. 21, 289.CrossRefGoogle Scholar
Dinning, J. S., Young, J. M., Simmons, M. R. & Day, P. L. (1954). Proc. Soc. exp. Biol. Med. 85, 280.CrossRefGoogle Scholar
Gerlóczy, F., Lancos, F. & Szabo, J. (1966). Acta paediat. hung. 7, 363.Google Scholar
Green, J., Diplock, A. T., Bunyan, J., McHale, D. & Muthy, I. R. (1967). Br. J. Nutr. 21, 69.CrossRefGoogle Scholar
György, P. & Rose, C. S. (1948). Science, N. Y. 108, 716.CrossRefGoogle Scholar
Jalavisto, E. (1954). Annls Med. exp. Biol. Fenn. 32, 195.Google Scholar
King, E. J. & Gilchrist, M. (1947). Lancet ii, 201.CrossRefGoogle Scholar
Lazier, B. B. & Beveridge, J. M. R. (1964). Can. J. Biochem. 42, 1809.CrossRefGoogle Scholar
Leonard, P. J. & Losowsky, M. S. (1967). Biochem. J. 103, 51P.Google Scholar
Majaj, A., Dinning, J. S., Azzam, S. & Darby, W. J. (1963). Am. J. clin. Nutr. 12, 374.CrossRefGoogle Scholar
Moore, T. (1949). Ann. N. Y. Acad. Sci. 52, 206.CrossRefGoogle Scholar
Oski, F. A. & Barness, L. A. (1967). J. Paediat. 70, 211.CrossRefGoogle Scholar
Peragello, I. & Fiori, E. (19381939). Z. VitamForsch. 8, 132.Google Scholar
Whitaker, J. A., Fort, E. G., Vimokesant, S. & Dinning, J. S. (1967). Am. J. clin. Nutr. 20, 783.CrossRefGoogle Scholar