Hostname: page-component-76fb5796d-wq484 Total loading time: 0 Render date: 2024-04-27T02:54:05.663Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of feeding and short-term fasting on water and electrolyte turnover in female mink (Mustela vison)

Published online by Cambridge University Press:  09 March 2007

Søren Wamberg ,
Anne-Helene Tauson  and
Jan Elnif
Søren Wamberg
Affiliation:
Department of Physiology, Institute of Medical Biology, Odense University, DK-5000 Odeme C, Denmark
Anne-Helene Tauson
Affiliation:
Division of Nutrition and Production, Department of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, DK-1870 Frederiksberg C, Denmark
Jan Elnif
Affiliation:
Division of Nutrition and Production, Department of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, DK-1870 Frederiksberg C, Denmark
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Daily (24 h) rates of water and electrolyte turnover were measured in a conventional balance study in ten adult female pastel mink (Mustela vison) given free access to a standard mink feed for a 1-week conditioning period, followed by a 4 d experimental period and a 2 d fasting period. Drinking water was available throughout. In addition, the completeness of urine collection and the fraction of urine collected with the faeces were determined using a new experimental technique based on 24 h recoveries of specific urinary markers such as tritiated p-aminohippuric acid ([3H]PAH) or 14C-1abelled inulin ([14C]IN) continuously delivered by small Alzet® osmotic pumps implanted intraperitoneally. During feeding the mean individual percentage recovery in urine of [3H]PAH released from tbe osmotic pumps ranged from 68 to 88% (median 78%). Tbe mean percentage of urinary [3H]PAH recovered from faecal collections was 6% (range 3–12%). In response to fasting the mean individual percentage recovery of [3H]PAH in urine ranged from 62 to 78% (median 68%). For urinary [14C]IN the mean percentage recoveries in fed and fasted animals were 79 and 63% respectively. Furthermore, during fasting, withdrawal of the supplies of dietary water caused a slight but insignificant (P = 0·17) increase in the daily intake of drinking water and, hence, the animals maintained their normal water balance by a dramatic reduction in urine excretion (P < 0·001). At the same time urinary solute excretion declined significantly (P < 0·001), due in part to the cessation of dietary electrolyte intake and in part to reduced formation of urea, whereas urinary osmolality decreased only moderately. The mean 24 h balances of Na, K, Ca, Mg, Cl and P were close to zero and only minor differences between the feeding and fasting periods were observed. When corrected for the measured inaccuracies in urine collection the balance data obtained in the present study represent useful reference standards for normally fed and fasted non-growing mink and, to some extent, useful guidelines for future studies in experimental animals.

Keywords

Carnivores[3H]-p-aminohippuric acidOsmotic pumpsUrine collection
Type
Animal Nutrition
Information
British Journal of Nutrition , Volume 76 , Issue 5 , November 1996 , pp. 711 - 725
Copyright
Copyright © The Nutrition Society 1996

References

REFERENCES

Abou-El-Makarem, M. M., Millburn, P., Smith, R. L. & Williams, R.T. (1967). Biliary excretion of foreign compounds. Benzene and its derivatives in the rat. Biochemical Journal 105, 1269–1274.Google Scholar
Adams, L.D., Polzin, D.J., Osborne, C.A. & O'Brien, T.D. (1991). Comparison of fractional excretion and 24-hour urinary excretion of sodium and potassium in clinically normal cats and cats with induced chronic renal failure. American Journal of Veterinary Research 52, 718–722.Google Scholar
Anonymous (1986). European Convention for the Protection of Vertebrate Animals Used for Experimental and other Scientific Purposes. European Treaty Series No. 123. Strasbourg: Council of Europe.Google Scholar
Anonymous (1989). Alzet Osmotic Pumps. Technical Information Manual. Palo Alto, CA: Alza Corporation.Google Scholar
Arvanitakis, C., Longnecker, M.P. & Folscroft, J. (1978). Characterization of p-aminobenzoic acid transport across the rat intestine. Journal of Laboratory and Clinical Medicine 91, 467–472.Google ScholarPubMed
Baginski, E.S., Foá, P.P. & Zak, B. (1967). Microdetermination of inorganic phosphate, phospholipids, and total phosphate in biologic materials. Clinical Chemistry 13, 326–332.Google Scholar
Blixenkrone-Møller, M., Lund, E., Mikkelsen, G. & Uttenthal, Å. (1987). Blood collection in mink. Scandinavian Journal of Laboratory Animal Science 14, 99.Google Scholar
Ching, S.V., Fettman, M.J., Hamar, D.W., Nagode, L.A. & Smith, K.R. (1989). The effect of chronic dietary acidification using ammonium chloride on acid-base and mineral metabolism in the adult cat. Journal of Nutrition 119, 902–915.Google Scholar
Chwalibog, A., Glem-Hansen, N., Henkel, S. & Thorbek, G. (1980). Energy metabolism in adult mink in relation to protein-energy levels and environmental temperature. In Energy Metabolism. EAAP Publication no. 26, pp. 283–286 [Mount, L.E., editor]. London: Buttenvorths.Google Scholar
Cotlove, E., Trantham, H.V. & Bowman, R.L. (1958). An instrument and method for automatic, rapid, accurate and sensitive titration of chloride in biologic samples. Journal of Laboratory and Clinical Medicine 51, 461–468.Google Scholar
Eckenhoff, B., Theeuwes, F. & Urquhart, J. (1981). Osmotically actuated dosage forms for rate-controlled drug delivery. Pharmaceutical Technology 5, 35–44.Google Scholar
Elnif, J. (1992). Accuracy of nitrogen balance measurements in adult mink. Norwegian Journal of Agricultural Sciences, Supplementum 9, 254–260.Google Scholar
Eriksson, L., Valtonen, M. & Mäkelä, J. (1984). Water and electrolyte balance in male mink (Mustela vison) on varying dietary NaCl intake. Acta Physiologica Scandinavica, Supplementum 537, 59–64.Google Scholar
Esteves, M.I., Marini, R.P., Ryden, E.B., Murphy, J.C. & Fox, J.G. (1994). Estimation of glomerular filtration rate and evaluation of renal function in ferrets (Mustela putorius furo). American Journal of Veterinary Research 55, 166–172.Google Scholar
Farrell, D.J. & Wood, A.J. (1968). The nutrition of the female mink (Mustela vison). III. The water requirement for maintenance. Canadian Journal of Zoology 46, 53–56.Google Scholar
Glem-Hansen, N. (1980). The protein requirements of mink during the growth period. I. Effect of protein intake on nitrogen balance. Acta Agriculturae Scandinavica 30, 336–344.Google Scholar
Hamlin, R.L. & Tashjian, R.J. (1964). Water and electrolyte intake and output and quantity of feces in healthy cats. Veterinary Medicine/Small Animals Clinics 59, 746–747.Google Scholar
Hegsted, D.M. (1976). Balance studies (Editorial). Journal of Nutrition 106, 307–311.Google Scholar
Houpt, T.R. (1993). Water and electrolytes. In Dukes' Physiology of Domestic Animals, 11th ed., pp. 9–21 [Swenson, M.J. and Reece, W.O, editors]. Ithaca and London: Cornell University Press.Google Scholar
Jeejeebhoy, K.N. (1986). Nutritional balance studies: indicators of human requirements or adaptive mechanisms. Journal of Nutrition 116, 2061–2063.Google Scholar
Jørgensen, G. & Glem-Hansen, N. (1973). A cage designed for metabolism and nitrogen balance trials with mink. Acta Agriculturae Scandinavica 23, 3–5.Google Scholar
Klatt, P., Muschaweck, R., Bossaller, W., Magerkurth, K.O. & Wanderbeke, O. (1975). Method of collecting urine and comparative investigation of quantities excreted by cats and dogs after administration of furosemide. American Journal of Veterinary Research 36, 919–923.Google Scholar
Knoche, H.W. (1991). Radioisotopic Methods for Biological and Medical Research, pp. 187–210. Oxford: Oxford University Press.Google Scholar
Müller-Peddinghaus, R., Hackbarth, H., Alt, J. & Küpper, W. (1979). Untersuchunge zur physiologischen Proteinurie des Nerzes. Vergleich von Proteinurie und Glomerulärer Filtrationsrate mit histologischen Befunden (Studies on physiological proteinuria in the mink. Comparison of proteinuria and glomerular filtration rate with histological findings). Zentralblatt für Veterinärmedizin, Rheie A 26, 130–145.Google Scholar
National Research Council (1982). Nutrient Requirements of Mink and Foxes, 2nd revised ed. NCR Publication no. 7. Washington, DC: National Academy Press.Google Scholar
Neil, M. (1988). Effects of dietary energetic composition and water content on water turnover in mink. Swedish Journal of Agricultural Research 18, 135–140.Google Scholar
René, E., Danzinger, R.G., Hofmann, A.F. & Nakagaki, M. (1983). Pharmacologic effect of somatostatin on bile formation in the dog. Gastroenterology 84, 120–129.Google Scholar
Russel, F.G.M., Wouterse, A.C. & Van Ginneken, C.A.M. (1989). Renal clearance of substituted hippurates in the dog. II. 4-Amino-, hydroxy- and methoxy-substituted benzoylglycines. Journal of Pharmacology and Experimental Therapeutics 248, 436–446.Google Scholar
Russo, E.A., Lees, G.E. & Hightower, D. (1986). Evaluation of renal function in cats, using quantitative urinalysis. American Journal of Veterinary Research 47, 1308–1312.Google Scholar
Sinclair, D.G. & Evans, E.V. (1962). A metabolism cage designed for use with mink. Canadian Journal of Biochemistry and Physiology 40, 1395–1399.Google Scholar
Sorfleet, J.L. & Chavez, E.R. (1980). Comparative biochemical profiles in blood and urine of two strains of mink and changes associated with the incidence of wet belly disease. Canadian Journal of Physiology and Pharmacology 58, 499–503.Google Scholar
Statistical Analysis Systems (1985). SAS User's Guide: Statistics, 1985 ed. Cary, NC: SAS Institute Inc.Google Scholar
Tauson, A.-H. (1991). Factors Affecting the Water Requirement of Mink. NJF-Seminar no. 92. Uppsala, Sweden: National Laboratory for Agricultural Chemistry.Google Scholar
Tauson, A.-H., Elnif, J. & Hansen, N.E. (1994). Energy metabolism and nutrient oxidation in the pregnant mink (Mustela vison) as a model for other carnivores. Journal of Nutrition 124, 2609S–2613S.Google Scholar
Theeuwes, F. & Yum, S.I. (1976). Principles of the design and operation of generic osmotic pumps for the delivery of semisolid or liquid drug formulations. Annals of Biomedical Engineering 4, 343–353.Google Scholar
Thornton, P.C., Wright, P.A., Sacra, P.J. & Goodier, T.E.W. (1979). The ferret, Mustela putorius furo, as a new species in toxicology. Laboratory Animals 13, 119–124.CrossRefGoogle ScholarPubMed
Wamberg, S. (1994). Rates of heat and water loss in female mink (Mustela vison) measured by direct calorimetry. Comparative Biochemistry and Physiology 107A, 451–458.Google Scholar
Wamberg, S., Clausen, T.N., Olesen, C.R. & Hansen, O. (1992 a). Nursing sickness in lactating mink (Mustela vison). II. Pathophysiology and changes in body fluid composition. Canadian Journal of Veterinary Research 56, 95–101.Google Scholar
Wamberg, S., Elnif, J. & Tauson, A.-H. (1995). Rates of urinary water, electrolyte and nitrogen excretion in fed and fasted female mink (Mustela vison). Acta Physiologica Scundinavica 155, 28A Abstr.Google Scholar
Wamberg, S., Elnif, J. & Tauson, A.-H. (1996 a). Assessment of the accuracy of quantitative urine collection in mink (Mustela vison) using osmotic pumps for continuous release of p-amino-hippuric acid and inulin. Laboratory Animals 30, 267–272.Google Scholar
Wamberg, S., Engel, K. & Stigsen, P. (1985). Acid-base balance in ruminating calves given sodium hydroxide-treated barley straw. British Journal of Nutrition 54, 655–667.Google Scholar
Wamberg, S., Kildeberg, P. & Engel, K. (1976). Balance of net base in the rat. I. A technical approach. Biology of the Neonate 28, 160–170.Google Scholar
Wamberg, S., Olesen, C.R. & Hansen, H.O. (1992 b). Influence of dietary sources of fat on lipid synthesis in mink (Mustela vison) mammary tissue. Comparative Biochemistry and Physiology 103A, 199–204.Google Scholar
Wamberg, S., Svendsen, P. & Johansen, B. (1996 b). Acid-base status and cardiovascular function in mink (Mustela vison) anaesthetized with ketamine/midazolam. Laboratory Animals 30, 55–66.Google Scholar
Worden, A.N. & Waterhouse, C.E. (1957). A metabolism cage for use with cats. Journal of Animal Technicians Association 8, 66–67.Google Scholar
Worden, A.N., Waterhouse, C.E. & Sellwood, E.H.B. (1960). Studies on the composition of normal cat urine. Journal of Small Animal Practice 1, 11–23.CrossRefGoogle Scholar