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Effects of dietary-fish-oil feeding on muscle growth and damage in the rat

Published online by Cambridge University Press:  09 March 2007

M. J. Jackson ,
J. Roberts  and
R. H. T. Edwards
M. J. Jackson
Affiliation:
Department of Medicine, University of Liverpool, PO Box 147, Liverpool L69 3BX
J. Roberts
Affiliation:
Department of Medicine, University of Liverpool, PO Box 147, Liverpool L69 3BX
R. H. T. Edwards
Affiliation:
Department of Medicine, University of Liverpool, PO Box 147, Liverpool L69 3BX
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Abstract

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1. Giving diets containing 100 g fully-refined, non-hydrogenated fish oil/kg to rats caused substantial modification of skeletal-muscle-membrane fatty acid composition compared with control animals fed on an equivalent diet containing 100 g maize oil/kg.

2. Total muscle arachidonic acid (20:4ω6) was reduced from 138 (sd 25) mg/g total fatty acids to 15 (sd 2) mg/ g and phospholipid arachidonic acid content showed equivalent changes.

3. Reduction in muscle arachidonic acid content had no influence on the growth of individual muscles.

4. Variation in muscle fatty acid composition exacerbated the response of muscle to calcium-induced damage assessed by efflux of intracellular creatine kinase (EC 2.7.3.2).

5. It is concluded that metabolites of arachidonic acid are unlikely to be primary controlling factors of muscle growth or specific mediators of muscle sarcolemmal damage leading to enzyme efflux.

Type
Clinical and Human Nutrition papers: Studies Relevant to Human Nutrition
Information
British Journal of Nutrition , Volume 60 , Issue 2 , September 1988 , pp. 217 - 224
Copyright
Copyright © The Nutrition Society 1988

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