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The effect of various levels of fructose in a copper-deficient diet on Cu deficiency in male rats

Published online by Cambridge University Press:  09 March 2007

Charles G. Lewis ,
Meira Fields  and
Todd Beal
Charles G. Lewis
Affiliation:
Carbohydrate Nutrition Laboratory, U.S. Department of Agriculture, Beltsville, Maryland 20705, USA
Meira Fields
Affiliation:
Carbohydrate Nutrition Laboratory, U.S. Department of Agriculture, Beltsville, Maryland 20705, USA Vitamin and Mineral Nutrition Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, Maryland 20705, USA Georgetown University Medical School, Washington DC 20007, USA
Todd Beal
Affiliation:
University of Maryland, College Park, Maryland 20742, USA
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Abstract

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The present study was designed to examine the effects of various levels of fructose in a copper-deficient diet on some of the signs of Cu deficiency in the rat. Weanling male rats were randomly assigned to one of five diets which contained 0.6 μg Cu/g diet and 627 g carbohydrate/kg which was (g/kg): 627 fructose (diet 100); 470 fructose, 157 starch (diet 75); 313.5 fructose, 313.5 starch (diet 50); 157 fructose, 470 starch (diet 25); or 627 starch (diet 0). Rats ate their respective diets for either 2 or 5 weeks. There was a significant linear inverse response of body-weight (P < 0.0001), packed cell volume (p < 0.0001) and erythrocyte superoxide dismutase (EC 1.15.1.1) activity (P < 0.008) to increasing levels of dietary fructose and a direct linear response of plasma cholesterol (P < 0.05) and blood urea nitrogen concentrations (P < 0.001) to increasing levels of dietary fructose. Liver, kidney and pancreatic Cu concentrations decreased in a dose-response manner as the level of dietary fructose increased. In general, if fructose was included in the diet the signs of Cu deficiency were exacerbated in a dose-response manner.

Keywords

Copper deficiencyFructoseRat
Type
Carbohydrate-Mineral Interaction
Information
British Journal of Nutrition , Volume 63 , Issue 2 , March 1990 , pp. 387 - 395
Copyright
Copyright © The Nutrition Society 1990

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