Hostname: page-component-848d4c4894-4rdrl Total loading time: 0 Render date: 2024-06-15T06:47:20.908Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of the protein content of the diet on the vitamin B12 status in rats

Published online by Cambridge University Press:  07 January 2011

V. S. Jathar ,
R. S. Satoskar ,
B. M. Mehta  and
D. V. Rege
V. S. Jathar
Affiliation:
Radioisotope Laboratory, Department of Pharmacology, Seth G.S. Medical College, Bombay-12, India
R. S. Satoskar
Affiliation:
Radioisotope Laboratory, Department of Pharmacology, Seth G.S. Medical College, Bombay-12, India
B. M. Mehta
Affiliation:
Department of Chemical Technology, Food Section, University of Bombay, Matunga, Bombay-19, India
D. V. Rege
Affiliation:
Department of Chemical Technology, Food Section, University of Bombay, Matunga, Bombay-19, India
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. The effects of the protein content of the diet on the vitamin B12 concentration of serum and of various tissues were studied in rats by means of microbiological and radioisotopic techniques.

2. Protein starvation reduced tissue weights and nitrogen contents, serum protein concentrations and haemoglobin values.

3. The vitamin B12 contents of the serum and of several organs and tissues were greater in the protein-starved animals for reasons that remain unexplained.

4. The retention of radioactive cyanocobalamin per g fresh weight was significantly greater in liver, kidney, spleen and brain in the protein-depleted rats than in those given adequate protein. However, the total tissue retention was not significantly different between these groups, so that there was a greater capacity for tissue binding and for body conservation of vitamin B12 in the protein-starved animals.

Type
General Nutrition
Information
British Journal of Nutrition , Volume 31 , Issue 2 , March 1974 , pp. 219 - 225
Copyright
Copyright © The Nutrition Society 1974

References

REFERENCES

Bhagwan, H. N., Rao, M. L. V. & Srenivasan, A. (1961). In Proceedings of a Symposim on Proteins at the Central Food Technological Research Institute, Mysore, India, August 14–16 1960, p. 129. India: Chemical Research Committee and Society of Biological Chemists.Google Scholar
Bonomo, E., Cova, N., Cremonuni, & Prete, S. D. (1960). Acta vitam., Milano 14, 9.Google Scholar
Dryden, L. P. & Hartman, A. M. (1971). J. Nutr. 101, 579.CrossRefGoogle Scholar
Foy, H. & Kondi, A. (1968). Vitams Horm. 26, 653.CrossRefGoogle Scholar
Gorall, A. G., Bardawill, C. J. & David, M. M. (1949). J. biol. Chem. 177, 751.CrossRefGoogle Scholar
Hawk, P. B. & Oser, B. L. (1931). Science, N.Y. 74, 369.CrossRefGoogle Scholar
Mackay, I. R., Cowling, D. C. & Gray, A. (1957). Br. med. J. ii, 800.CrossRefGoogle Scholar
Moore, T. & Sharman, I. M. (1951). Br. J. Nutr. 5, 119.CrossRefGoogle Scholar
Miller, O. N., Hansen, H. J. & Raney, J. L. (1963). Archs Biochem. Biophys. 100, 214.CrossRefGoogle Scholar
Rachmilewitz, M., Aronovitch, J. & Grossowicz, N. (1956). J. Lab. Clin. Med. 48, 339.Google Scholar
Rosenthal, H. L. (1961). Proc. int. Congr. Nutr. v. Wash. p. 62.Google Scholar
Ross, G. I. M. (1962). J. clin. Path. 5, 250.CrossRefGoogle Scholar
Satoskar, R. S., Kulkarni, B. S., Mehta, B. M., Sanzgiri, R. R. & Bamji, M. S. (1962). Archs Dis. Childh. 37, 9.CrossRefGoogle Scholar
Scrimshaw, N. S., Behar, M., Guzman, M., Viteri, F. & Arroyave, G. (1955). Fedn Proc. Fedn. Am. Socs exp. Biol. 14, 449.Google Scholar
Scrimshaw, N. S., Behar, M., Perez, C. & Viteri, F. (1955). Pediatrics, Springfield 16, 378.CrossRefGoogle Scholar
Sivakumra, B., Nath, N. & Nath, M. C. (1969). J. Vitam. 15, 151.CrossRefGoogle Scholar
Trowell, H. C., Moore, T. & Sharman, I. M. (1954). Ann. N.Y. Acad. Sci. 57, 734.CrossRefGoogle Scholar
Viteri, F. E., Alvarado, J., Luthringer, D. G. & Wood, R. P. (1968). Vitams Horm. 26, 573.CrossRefGoogle Scholar
Wintrobe, M. M. (1956). Clinical Haematology 4th ed. London: Kimpton.Google Scholar
Wolff, R. & Nebat, P. (1962). In Vitamin B12 and Intrinsic Factor. 2. Europäisches Symposion 1961, p. 514 [Heinrich, H. C., editor]. Stuttgart: Ferdinsand Enke.Google Scholar