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Duyun compound green tea extracts regulate bile acid metabolism on mice induced by high-fat diet

Published online by Cambridge University Press:  10 October 2022

Xiaolu Zhou Open the ORCID record for Xiaolu Zhou [Opens in a new window] ,
Yaling Li ,
Ren Mu ,
Chuanming Wang ,
Yuyan Song ,
Caibi Zhou  and
Xin Mei
Xiaolu Zhou
Affiliation:
College of Biological Sciences and Agriculture, Qiannan Normal University for Nationalities, Duyun 558000, People’s Republic of China School of Crop Production Technology, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
Yaling Li
Affiliation:
College of Biological Sciences and Agriculture, Qiannan Normal University for Nationalities, Duyun 558000, People’s Republic of China School of Tea and Food Technology, Anhui Agriculture University, Hefei 230036, People’s Republic of China
Ren Mu
Affiliation:
College of Biological Sciences and Agriculture, Qiannan Normal University for Nationalities, Duyun 558000, People’s Republic of China
Chuanming Wang
Affiliation:
School of Pharmacy, Qiannan Medical College for Nationalities, Duyun 558000, People’s Republic of China
Yuyan Song
Affiliation:
College of Biological Sciences and Agriculture, Qiannan Normal University for Nationalities, Duyun 558000, People’s Republic of China
Caibi Zhou*
Affiliation:
College of Biological Sciences and Agriculture, Qiannan Normal University for Nationalities, Duyun 558000, People’s Republic of China School of Crop Production Technology, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
Xin Mei*
Affiliation:
College of Biological Sciences and Agriculture, Qiannan Normal University for Nationalities, Duyun 558000, People’s Republic of China
*
* Corresponding authors: Caibi Zhou, email teasky@foxmail.com; Xin Mei, email xmeisci@yeah.net
* Corresponding authors: Caibi Zhou, email teasky@foxmail.com; Xin Mei, email xmeisci@yeah.net
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Abstract

Duyun compound green tea (DCGT) is a healthy beverage with lipid-lowering effect commonly consumed by local people, but its mechanism is not very clear. We evaluated the effect of DCGT treatment on bile acids (BA) metabolism of mice with high-fat diet (HFD) – induced hyperlipidaemia by biochemical indexes and metabolomics and preliminarily determined the potential biomarkers and metabolic pathways of hyperlipidaemia mice treated with DCGT as well as investigated its lipid-lowering mechanism. The results showed that DCGT treatment could reduce HFD – induced gain in weight and improve dyslipidaemia. In addition, a total of ten types of BA were detected, of which seven changed BA metabolites were observed in HFD group mice. After DCGT treatment, glycocholic acid, tauroursodeoxycholic acid and taurochenodeoxycholic acid were significantly down-regulated, while hyodeoxycholic acid, deoxycholic acid and chenodeoxycholic acid were markedly up-regulated. These results demonstrated that DCGT treatment was able to make the BA metabolites in the liver of hyperlipidaemia mice normal and alleviate hyperlipidaemia by regulating the metabolites such as glycocholic acid, tauroursodeoxycholic acid and taurochenodeoxycholic, as well as the BA metabolic pathway and cholesterol metabolic pathway involved.

Keywords

HyperlipidaemiaTeaMetaboliteMetabonomicsBile acids
Type
Research Article
Information
British Journal of Nutrition , Volume 130 , Issue 1 , 14 July 2023 , pp. 33 - 41
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society

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Footnotes

†

These authors are first authors and contributed equally to this work.

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