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Copper homeostasis in rats fed on a high-sulphide diet

Published online by Cambridge University Press:  09 March 2007

Shiguang Yu  and
Anton C. Beynen
Shiguang Yu
Affiliation:
Department of Human Nutrition, Wageningen Agricultural University, PO Box 8129, 6700 EV Wageningen, The Netherlands Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, PO Box 80.166, 3508 TD Utrecht, The Netherlands
Anton C. Beynen
Affiliation:
Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, PO Box 80.166, 3508 TD Utrecht, The Netherlands
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Abstract

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The mechanism underlying the reduced Cu status in rats fed on a high-sulphide diet was investigated. Male rats aged 6 weeks were fed ad libitum on purified diets containing either 0 or 500 mg S2-/kg and demineralized water for a period of 2 weeks. The high-sulphide diet had no effect on feed intake, body-weight gain or weight of liver and kidney bat significantly reduced Cu concentrations in plasma and kidney. Biliary Cu excretion was decreased significantly in rats fed on the high-sulphide diet. Apparent Cu absorption (Cu intake -faecal Cu) and true Cu absorption (Cu intake - (faecal Cu - biliary Cu)) were significantly lowered after sulphide feeding for 2 weeks. Rats fed on the high-sulphide diet excreted less Cu in urine than did the controls. We conclude that high sulphide intake reduces Cu status in rats through inhibition of Cu absorption which is reflected by a decrease in biliary Cu excretion as a secondary feature

Keywords

SulphideCopperBiliary excretionRat
Type
General Nutrition
Information
British Journal of Nutrition , Volume 76 , Issue 6 , December 1996 , pp. 909 - 914
Copyright
Copyright © The Nutrition Society 1997

References

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