Hostname: page-component-5c6d5d7d68-wbk2r Total loading time: 0 Render date: 2024-08-18T16:40:22.188Z Has data issue: false hasContentIssue false
  • English
  • Français

Comparison of the lipid compositions of the aortic lesions in rabbits given different atherogenic diets

Published online by Cambridge University Press:  09 March 2007

J. H. Moore
J. H. Moore
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. The compositions of the lipids in the atheromatous lesions of rabbits have been studied in an experiment in which two groups of rabbits (twelve/group) were given different atherogenic diets for a period of 38 weeks. One group of rabbits was given a diet in which 35% of the total calories was derived from butterfat and the other group was given a diet in which 48% of the total calories was derived from starch.

2. At the end of the feeding period the rabbits were killed and the atheromatous plaques were dissected out from the aortic intima of each rabbit. The lipid compositions of the aortic lesions were determined and the results compared with the compositions of the plasma lipids.

3. In the lipids of the aortic lesions in the rabbits given the high-butterfat diet, the proportions of cholesterol and cholesterol esters were higher and the proportion of triglycerides was lower than in the lipids of the aortic lesions in the rabbits given the high-starch diet. Irrespective of dietary treatment, free cholesterol constituted a higher proportion of the lesion lipids than it did of the plasma lipids.

4. In the rabbits on either dietary treatment, the lesion cholesterol esters contained higher concentrations of oleic acid and lower concentrations of linoleic acid than did the plasma cholesterol esters. In the lesion phospholipids there were higher concentrations of palmitic, palmitoleic, stearic and oleic acids and lower concentrations of linoleic and arachidonic acids than in the plasma phospholipids.

5. In both groups of rabbits the phospholipids of the aortic lesions contained higher proportions of cephalin and sphingomyelin and lower proportions of lecithin than did the plasma phospholipids.

6. The results of this investigation are discussed in relation to the possible origins of the lipids in the aortic lesions of the experimental rabbits.

Type
Research Article
Information
British Journal of Nutrition , Volume 21 , Issue 3 , September 1967 , pp. 715 - 724
Copyright
Copyright © The Nutrition Society 1967

References

Biggs, M. W. & Kritchevsky, D. (1951). Circulation 4, 34.CrossRefGoogle Scholar
Böttcher, C. J. F., Boelsma-van Houte, E., ter Haar Romeny-Wachter, C. Ch., Woodford, F. P. & van Gent, C. M. (1960). Lancet ii, 1162.CrossRefGoogle Scholar
Böttcher, C. J. F. & van Gent, C.M. (1961). J. Atheroscler. Res. 1, 36.CrossRefGoogle Scholar
Böttcher, C. F. J., Woodford, F.P., Boelsma-van Houte, E. & van Gent, C.M. (1959). Rec. Trav. chim. Pays-Bas Belg. 78, 794.CrossRefGoogle Scholar
Böttcher, C. J. F., Woodford, F.P., ter Haar Romeny-Wachter, C. Ch., Boelsma-van Houte, E. & van Gent, C. M. (1960). Lancet ii, 1378.CrossRefGoogle Scholar
Buck, R.C. & Rossiter, R. J. (1951). Archs Path. 51, 224.Google Scholar
Constantinides, P., Booth, J. & Carlson, E. (1960). Archs Path. 70, 712.Google Scholar
Drury, A. & Swell, L. (1960). Am. J. Physiol. 198, 363.CrossRefGoogle Scholar
Evrard, E., van den Bosch, J., de Somer, P. & Joosens, J. V. (1962). J. Nutr. 76, 219.CrossRefGoogle Scholar
Farquhar, J.W., Insull, W. J., Rosen, P., Stoffel, W. & Ahrens, E.H. Jr (1959). Nutr. Rev. 17, Suppl.Google Scholar
Folch, J., Lees, M. & Stanley, G.H.S. (1957). J. biol. Chem. 226, 497.CrossRefGoogle Scholar
Geer, J.C. & Malcom, G.T. (1965). Exp. molec. Path. 4, 500.CrossRefGoogle Scholar
Lawrie, T.D.V. (1963). Biochem. Soc. Symp. no. 24, p. 101.Google Scholar
Lewis, B. (1958). Lancet ii, 71.CrossRefGoogle Scholar
Luddy, F.E., Barford, R.A., Riemenschneider, R.W. & Evans, J.D. (1958). J. biol. Chem. 232, 843.CrossRefGoogle Scholar
Masoro, E.J., Chaikoff, I.L., Chernick, S.S. & Felts, J.M. (1950). J. biol. Chem. 185, 845.CrossRefGoogle Scholar
Moore, J.H. (1962). J. Dairy Res. 29, 141.CrossRefGoogle Scholar
Moore, J.H. & Doran, B.M. (1962). Biochem. J. 84, 506.CrossRefGoogle Scholar
Moore, J.H. & Kon, S.K. (1963). Chemy Ind. p. 165.Google Scholar
Moore, J.H. & Williams, D.L. (1963). Can. J. Biochem. Physiol. 41, 1821.CrossRefGoogle Scholar
Moore, J.H. & Williams, D.L. (1964 a). Biochim. biophys. Acta 84, 41.Google Scholar
Moore, J.H. & Williams, D.L. (1964 b). Br. J. Nutr. 18, 253.CrossRefGoogle Scholar
Moore, J.H. & Williams, D.L. (1964 c). Br. J. Nutr. 18, 431.CrossRefGoogle Scholar
Moore, J.H. & Williams, D.L. (1964 d). Br. J. Nutr. 18, 603.CrossRefGoogle Scholar
Moore, J.H. & Williams, D.L. (1965). Br. J. Nutr. 19, 407.CrossRefGoogle Scholar
Moore, J.H. & Williams, D.L. (1966 a). Br. J. Nutr. 20, 79.CrossRefGoogle Scholar
Moore, J.H. & Williams, D.L. (1966 b). Br. J. Nutr. 20, 571.CrossRefGoogle Scholar
Newman, H.A.I., McCandless, E.L. & Zilversmit, D.B. (1961). J. biol Chem. 236, 1264.CrossRefGoogle Scholar
Newman, H.A.I. & Zilversmit, D.B. (1962). J. biol. Chem. 237, 2078.CrossRefGoogle Scholar
Noble, R.C. & Moore, J.H. (1965). Can. J. Biochem. 43, 1677.CrossRefGoogle Scholar
Schrade, W., Böhle, E. & Biegler, R. (1959). Klin. Wschr. 37, 1101.CrossRefGoogle Scholar
Schwenk, E. & Stevens, D.F. (1960). Proc. Soc. exp. Biol. Med. 103, 614.CrossRefGoogle Scholar
Shore, M.L., Zilversmit, D.B. & Ackerman, R.F. (1955). Am. J. Physiol. 181, 527.CrossRefGoogle Scholar
Smith, E.B. (1959). Biochem. J. 73, 34.Google Scholar
Smith, E.B. (1962). Biochem. J. 84, 49.Google Scholar
Swell, L., Field, H. J., Schools, P.E. Jr & Treadwell, C.R. (1960 a). Proc. Soc. exp. Biol. Med. 103, 651.CrossRefGoogle Scholar
Swell, L., Field, H. J., Schools, P.E. Jr & Treadwell, C.R. (1960 b). Proc. Soc. exp. Biol. Med. 105, 662.CrossRefGoogle Scholar
Swell, L., Law, M.D., Schools, P.E. Jr & Treadwell, C.R. (1961). J. Nutr. 75, 181.CrossRefGoogle Scholar
Swell, L., Law, M.D. & Treadwell, C.R. (1962). J. Nutr. 76, 429.CrossRefGoogle Scholar
Tuna, N., Reckers, L. & Frantz, I. D. Jr (1958). J. clin. Invest. 37, 1153.CrossRefGoogle Scholar
Weinhouse, S. & Hirsch, E.F. (1940). Archs Path. 29, 31.Google Scholar
Wright, A.S., Pitt, G.A.J. & Morton, R.A. (1959). Lancet ii, 594.CrossRefGoogle Scholar
Zilversmit, D.B., Shore, M.L. & Ackerman, R.F. (1954). Circulation 9, 581.CrossRefGoogle Scholar
Zilversmit, D.B., Sweeley, C.C. & Newman, H.A.I. (1961). Circulation Res. 9, 235.CrossRefGoogle Scholar