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Biotin deficiency and susceptibility to fatty liver and kidney syndrome in broiler chicks: reduced 6-phosphofructokinase (EC 2.7.1.11) activity but normal fructose 2,6-bisphosphate content in birds with hepatomegaly

Published online by Cambridge University Press:  09 March 2007

D. W. Bannister ,
D. I. Sales  and
Alison Lee
D. W. Bannister
Affiliation:
Agricultural and Food Research Council's Poultry Research Centre, Roslin, Midlothian EH25 9PS
D. I. Sales
Affiliation:
Agricultural and Food Research Council's Poultry Research Centre, Roslin, Midlothian EH25 9PS
Alison Lee
Affiliation:
Agricultural and Food Research Council's Poultry Research Centre, Roslin, Midlothian EH25 9PS
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Abstract

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1. In two separate experiments, using different strains, broiler chicks were reared on either a commercial-type chick mash (control) or a fatty liver and kidney syndrome (FLKS)-inducing diet.

2. In Expt a, chicks were killed on day 29 and in Expt b, on day 32. Body-weights and liver weights were measured, and values from those given the control ration used to construct a hepatomegaly index by employing a variant of linear discriminant analysis.

3. Application of the index to FLKS birds revealed a statistically significant bimodal distribution of liver size.

4. The birds with enlarged livers (high index) also possessed metabolic abnormalities in that 6- phosphofructokinase (EC 2. 7. 1. 11; PFK-1) activity (measured at low substrate concentration) was depressed despite the presence of normal, or even slightly elevated fructose 2,6-bisphosphate concentration.

5. This indicates the presence of an uncharacterized regulatory mechanism for PFK- 1 in FLKS-susceptible birds.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 54 , Issue 2 , September 1985 , pp. 535 - 543
Copyright
Copyright © The Nutrition Society 1985

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