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The acute effect of D-tagatose on food intake in human subjects

Published online by Cambridge University Press:  09 March 2007

Benjamin Buemann ,
Søren Toubro ,
Anne Raben ,
John Blundell  and
Arne Astrup
Benjamin Buemann*
Affiliation:
Research Department of Human Nutrition & Centre for Food Research, The Royal Veterinary and Agricultural University, 1958 Frederiksberg, Denmark
Søren Toubro
Affiliation:
Research Department of Human Nutrition & Centre for Food Research, The Royal Veterinary and Agricultural University, 1958 Frederiksberg, Denmark
Anne Raben
Affiliation:
Research Department of Human Nutrition & Centre for Food Research, The Royal Veterinary and Agricultural University, 1958 Frederiksberg, Denmark
John Blundell
Affiliation:
Research Department of Human Nutrition & Centre for Food Research, The Royal Veterinary and Agricultural University, 1958 Frederiksberg, Denmark
Arne Astrup
Affiliation:
Research Department of Human Nutrition & Centre for Food Research, The Royal Veterinary and Agricultural University, 1958 Frederiksberg, Denmark
*
*Corresponding author: Dr Benjamin Buemann, fax +45 35 282 483, email bbu@kvl.dk
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Abstract

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A double-blind randomized crossover study was performed with nineteen normal-weight men to investigate the effect on subsequent ad libitum food intake of replacing 29 g sucrose with 29 g D-TAGATOSE AS SWEETENER TO A BREAKFAST MEAL. d-Tagatose is a malabsorbed stereoisomer of fructose with potential application as a bulk sweetener. Food intake was measured at lunch offered 4 h after the breakfast meal, during the afternoon with access to abundant snacks, and finally at a supper buffet 9 h after the breakfast. Energy intake at lunch and during the snacking period was similar after ingesting the two sugars, while it was 15 % lower after ingesting d-tagatose than with sucrose at supper (P < 0·05). Gastrointestinal factors such as the osmotic effects of unabsorbed d-tagatose causing distension of the gut might have mediated the acute appetite-suppressing effect. The present paper also refers to data from a preceding study in which we observed an increased self-reported energy intake after ingestion of d-tagatose compared with sucrose which, in fact, suggests a relative hyperphagic effect of d-tagatose. However, self-reported food intake may be biased by selective under-reporting and this subsequent study with a more controlled assessment of food intake was therefore conducted. This present study did not support any hyperphagic effect of d-tagatose, but rather suggests that d-tagatose may contribute to a reduced energy intake.

Keywords

Appetited-TagatoseFood intake
Type
Research Article
Information
British Journal of Nutrition , Volume 84 , Issue 2 , August 2000 , pp. 227 - 231
Copyright
Copyright © The Nutrition Society 2000

References

Black, AE, Goldberg, SA, Jebb, SA, Livingstone, MBE, Cole, TJ and Prentice, AM (1991) Critical evaluation of energy intake data using fundamental principles of energy physiology: 2. Evaluating the results of published surveys. European Journal of Clinical Nutrition 45, 583–599.Google ScholarPubMed
Blackburn, GL, Kanders, BS, Lavin, PT, Keller, SD and Whatley, J (1997) The effect of aspartame as part of a multidisciplinary weight-control program on short- and long-term control of body weight. American Journal of Clinical Nutrition 65, 409–418.CrossRefGoogle Scholar
Buemann, B, Toubro, S and Astrup, A (1998) D-Tagatose, a stereoisomer of D-fructose, increases hydrogen production in humans without affecting 24-hour energy expenditure or respiratory exchange ratio. Journal of Nutrition 128, 1481–1486.Google Scholar
Buemann, B, Toubro, S, Holst, JJ, Rehfeld, JF and Astrup, A (2000) D-Tagatose, a stereoisomer of D-fructose increases blood uric acid concentration Metabolism (In the Press).CrossRefGoogle ScholarPubMed
Friedman, MI (1997) An energy sensor for control of energy intake. Proceedings of the Nutrition Society 56, 41–50.CrossRefGoogle ScholarPubMed
Kruger, CL, Whittaker, MH, Frankos, VH and Trimmer, GW (1999) 90-Day oral toxicity study of D-tagatose in rats. Regulatory Toxicology and Pharmacology 29, S1–S10.CrossRefGoogle ScholarPubMed
Lærke, HN and Jensen, BB (1999) D-Tagatose has low small intestinal digestibility but high large intestinal fermentability in pigs. Journal of Nutrition 129, 1002–1009.Google Scholar
Lavin, JH, French, SJ and Read, NW (1997) The effect of sucrose- and aspartame- sweetened drinks on energy intake, hunger and food choice of female, moderately restrained eaters. International Journal of Obesity 21, 37–42.CrossRefGoogle ScholarPubMed
Livingstone, MBE, Prentice, AM, Strain, JJ, Coward, WA, Black, AE, Barker, ME, McKenna PG and Whitehead, RG (1990) Accuracy of weighed dietary records in studies of diet and health. British Medical Journal 300, 708–712.CrossRefGoogle ScholarPubMed
Mifflin, MD, St Jeor, ST, Hill, LA, Scott, BJ, Daugherty, SA and Koh, YO (1990) A new predictive equation for resting energy expenditure in healthy individuals. American Journal of Clinical Nutrition 51, 241–247.CrossRefGoogle ScholarPubMed
Moyer, AE and Rodin, J (1993) Fructose and behavior: does fructose influence food intake and macronutrient selection?. American Journal of Clinical Nutrition 58 (Suppl.), 810S–814S.CrossRefGoogle ScholarPubMed
Raben, A, Tatjana, HV, Møller, C and Astrup, A (1996) Sucrose vs artificial sweeteners: Minor differences in body weight after 10 weeks. International Journal of Obesity 20 (Suppl. 4), 51.Google Scholar
Rawson, NE and Friedman, MI (1994) Phosphate loading prevents the decrease in ATP and increase in food intake produced by 2,5-anhydro-D-mannitol. American Journal of Physiology 266, R1792–R1796.Google ScholarPubMed
Rawson, NE, Blum, H, Osbakken, MD and Friedman, MI (1994) Hepatic phosphate trapping, decreased ATP, and increased feeding after 2,5-anhydro-D-mannitol. American Journal of Physiology 266, R112–R117.Google ScholarPubMed
Riquelme, P, Wernette-Hammond, ME, Kneer, NM and Lardy, HA (1984) Mechanism of action of 2,5-anhydro-D-mannitol in hepatocytes. Effects of phosphorylated metabolites on enzymes of carbohydrate metabolism. Journal of Biological Chemistry 259, 5115–5123.CrossRefGoogle Scholar
Rolls, BJ (1991) Effects of intense sweeteners on hunger, food intake, and body weight: a review. American Journal of Clinical Nutrition 53, 872–878.CrossRefGoogle ScholarPubMed
Scharrer, E and Langhans, W (1988) Metabolic and hormonal factors controlling food intake. International Journal of Vitamin and Nutrition Research 58, 249–261.Google ScholarPubMed
Vincent, MF, Van den Berghe, G and Hers, H-G (1986) Effect of fructose on the concentration of phosphoribosylpyrophosphate in isolated hepatocytes. Advanced Experimental Medical Biology 195(Pt. B), 615–621.Google Scholar