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Re-exploration of dietary iodine intake in Chinese adult males using a modified iodine balance study

Published online by Cambridge University Press:  06 March 2023

Xiaobing Liu
Affiliation:
Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health, Beijing 100050, People’s Republic of China Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong 518020, People’s Republic of China
Jun Wang
Affiliation:
Shenzhen Polytechnic, School of Food and Drug, Shenzhen, Guangdong 518055, People’s Republic of China
Yajie Li
Affiliation:
Changzhi Medical College, Changzhi, Shanxi 046000, People’s Republic of China
Hongxing Tan
Affiliation:
Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong 518020, People’s Republic of China
Xiuwei Li
Affiliation:
Chinese Center for Disease Control and Prevention, National Reference Laboratory for Iodine Deficiency Disorders, Beijing 100050, People’s Republic of China
Deqian Mao
Affiliation:
Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health, Beijing 100050, People’s Republic of China
Yanyan Liu
Affiliation:
Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong 518020, People’s Republic of China
Weidong Li
Affiliation:
Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health, Beijing 100050, People’s Republic of China
Wei Yu
Affiliation:
Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong 518020, People’s Republic of China
Jiaxi Lu
Affiliation:
Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health, Beijing 100050, People’s Republic of China
Junan Yan
Affiliation:
Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong 518020, People’s Republic of China
Jianhua Piao
Affiliation:
Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health, Beijing 100050, People’s Republic of China
Lichen Yang
Affiliation:
Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health, Beijing 100050, People’s Republic of China
Chongzheng Guo*
Affiliation:
Changzhi Medical College, Changzhi, Shanxi 046000, People’s Republic of China
Xiaoli Liu*
Affiliation:
Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong 518020, People’s Republic of China
Xiaoguang Yang*
Affiliation:
Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health, Beijing 100050, People’s Republic of China Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong 518020, People’s Republic of China
*
*Corresponding authors: Xiaoguang Yang, email xgyangcdc@163.com; Xiaoli Liu, email liuxl36@126.com; Chongzheng Guo, email gczmed@126.com
*Corresponding authors: Xiaoguang Yang, email xgyangcdc@163.com; Xiaoli Liu, email liuxl36@126.com; Chongzheng Guo, email gczmed@126.com
*Corresponding authors: Xiaoguang Yang, email xgyangcdc@163.com; Xiaoli Liu, email liuxl36@126.com; Chongzheng Guo, email gczmed@126.com

Abstract

There is still controversy about optimal dietary iodine intake as the Universal Salt Iodization policy enforcement in China. A modified iodine balance study was thus conducted to explore the suitable iodine intake in Chinese adult males using the iodine overflow hypothesis. In this study, thirty-eight apparently healthy males (19·1 (sd 0·6) years) were recruited and provided with designed diets. After the 14-d iodine depletion, daily iodine intake gradually increased in the 30-d iodine supplementation, consisting of six stages and each of 5 d. All foods and excreta (urine, faeces) were collected to examine daily iodine intake, iodine excretion and the changes of iodine increment in relation to those values at stage 1. The dose–response associations of iodine intake increment with excretion increment were fitted by the mixed effects models, as well as with retention increment. Daily iodine intake and excretion were 16·3 and 54·3 μg/d at stage 1, and iodine intake increment increased from 11·2 μg/d at stage 2 to 118·0 μg/d at stage 6, while excretion increment elevated from 21·5 to 95·0 μg/d. A zero iodine balance was dynamically achieved as 48·0 μg/d of iodine intake. The estimated average requirement and recommended nutrient intake were severally 48·0 and 67·2 μg/d, which could be corresponded to a daily iodine intake of 0·74 and 1·04 μg/kg per d. The results of our study indicate that roughly half of current iodine intakes recommendation could be enough in Chinese adult males, which would be beneficial for the revision of dietary reference intakes.

Type
Research Article
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society

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Footnotes

These authors equally contributed to this work

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