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Carotenoids in maternal and cord blood, breast milk and their association with maternal dietary intake: a longitudinal study in Shanghai, China

Published online by Cambridge University Press:  06 November 2023

Anran Sun
Affiliation:
West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, People’s Republic of China Food Safety Monitoring and Risk Assessment Key Laboratory of Sichuan Province, Chengdu 610041, People’s Republic of China
Luojia Tian
Affiliation:
West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, People’s Republic of China Food Safety Monitoring and Risk Assessment Key Laboratory of Sichuan Province, Chengdu 610041, People’s Republic of China
Xiaoying Xiong
Affiliation:
Abbott Nutrition Research & Development Centre, Shanghai 200233, People’s Republic of China
Matthew Kuchan
Affiliation:
Abbott Nutrition Research & Development Center, Abbott Laboratories, Columbus, OH 43219, USA
Xinyao Dai
Affiliation:
West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, People’s Republic of China Food Safety Monitoring and Risk Assessment Key Laboratory of Sichuan Province, Chengdu 610041, People’s Republic of China
Hanxiao Sun
Affiliation:
West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, People’s Republic of China Food Safety Monitoring and Risk Assessment Key Laboratory of Sichuan Province, Chengdu 610041, People’s Republic of China
He Wang
Affiliation:
West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, People’s Republic of China Food Safety Monitoring and Risk Assessment Key Laboratory of Sichuan Province, Chengdu 610041, People’s Republic of China
Xiang Li
Affiliation:
Abbott Nutrition Research & Development Centre, Shanghai 200233, People’s Republic of China
Lishi Zhang
Affiliation:
West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, People’s Republic of China Food Safety Monitoring and Risk Assessment Key Laboratory of Sichuan Province, Chengdu 610041, People’s Republic of China
Yanrong Zhao
Affiliation:
Abbott Nutrition Research & Development Centre, Shanghai 200233, People’s Republic of China
Jinyao Chen
Affiliation:
West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, People’s Republic of China Food Safety Monitoring and Risk Assessment Key Laboratory of Sichuan Province, Chengdu 610041, People’s Republic of China
Yingyi Mao*
Affiliation:
Abbott Nutrition Research & Development Centre, Shanghai 200233, People’s Republic of China
Xiaomeng Li*
Affiliation:
West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, People’s Republic of China Food Safety Monitoring and Risk Assessment Key Laboratory of Sichuan Province, Chengdu 610041, People’s Republic of China
*
*Corresponding authors: Yingyi Mao, email yingyi.mao@abbott.com; Xiaomeng Li, email 18215601611@126.com
*Corresponding authors: Yingyi Mao, email yingyi.mao@abbott.com; Xiaomeng Li, email 18215601611@126.com

Abstract

Carotenoids are important bioactive substances in breast milk, the profile of which is seldom studied. This study aimed to explore the profile of carotenoids in breast milk and maternal/cord plasma of healthy mother–neonate pairs in Shanghai, China, and their correlation with dietary intake. Maternal blood, umbilical cord blood and breast milk samples from five lactation stages (colostrum, transitional milk and early-, mid- and late-term mature milk) were collected. Carotenoid levels were analysed by HPLC. Carotenoid levels in breast milk changed as lactation progressed (P < 0·001). β-Carotene was the primary carotenoid in colostrum. Lutein accounted for approximately 50 % of total carotenoids in transitional milk, mature milk and cord blood. Positive correlations were observed between five carotenoids in umbilical cord blood and maternal blood (P all < 0·001). β-Carotene levels were also correlated between maternal plasma and three stages of breast milk (r = 0·605, P < 0·001; r = 0·456, P = 0·011, r = 0·446; P = 0·013, respectively). Dietary carotenoid intakes of lactating mothers also differed across lactation stages, although no correlation with breast milk concentrations was found. These findings suggest the importance of exploring the transport mechanism of carotenoids between mothers and infants and help guide the development of formulas for Chinese infants as well as the nutritional diets of lactating mothers.

Type
Research Article
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society

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