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Combining integrated systems-biology approaches with intervention-based experimental design provides a higher-resolution path forward for microbiome research

Published online by Cambridge University Press:  15 July 2019

J. Alfredo Blakeley-Ruiz
Affiliation:
Oak Ridge National Laboratory, Oak Ridge, TN 37830. hettichrl@ornl.gov University of Tennessee–Knoxville, Knoxville, TN 37996. jblakele@vols.utk.edurlydic@utk.eduhbaghdoy@utk.edu
Carlee S. McClintock
Affiliation:
Pain Consultants of East Tennessee, P.L.L.C., Knoxville, TN 37909. cmcclintock@painconsultants.comjchoo@painconsultants.com
Ralph Lydic
Affiliation:
Oak Ridge National Laboratory, Oak Ridge, TN 37830. hettichrl@ornl.gov University of Tennessee–Knoxville, Knoxville, TN 37996. jblakele@vols.utk.edurlydic@utk.eduhbaghdoy@utk.edu
Helen A. Baghdoyan
Affiliation:
Oak Ridge National Laboratory, Oak Ridge, TN 37830. hettichrl@ornl.gov University of Tennessee–Knoxville, Knoxville, TN 37996. jblakele@vols.utk.edurlydic@utk.eduhbaghdoy@utk.edu
James J. Choo
Affiliation:
Pain Consultants of East Tennessee, P.L.L.C., Knoxville, TN 37909. cmcclintock@painconsultants.comjchoo@painconsultants.com
Robert L. Hettich
Affiliation:
Oak Ridge National Laboratory, Oak Ridge, TN 37830. hettichrl@ornl.gov University of Tennessee–Knoxville, Knoxville, TN 37996. jblakele@vols.utk.edurlydic@utk.eduhbaghdoy@utk.edu

Abstract

The Hooks et al. review of microbiota-gut-brain (MGB) literature provides a constructive criticism of the general approaches encompassing MGB research. This commentary extends their review by: (a) highlighting capabilities of advanced systems-biology “-omics” techniques for microbiome research and (b) recommending that combining these high-resolution techniques with intervention-based experimental design may be the path forward for future MGB research.

Type
Open Peer Commentary
Copyright
Copyright © Cambridge University Press 2019 

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Combining integrated systems-biology approaches with intervention-based experimental design provides a higher-resolution path forward for microbiome research
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