Hostname: page-component-76fb5796d-2lccl Total loading time: 0 Render date: 2024-04-26T01:14:48.828Z Has data issue: false hasContentIssue false
  • English
  • Français

Embryonic Determination of Brain Programming Asymmetry - A Neglected Element in Twin-Study Genetics of Human Mental Development

Published online by Cambridge University Press:  01 August 2014

Charles E. Boklage
Charles E. Boklage*
Affiliation:
Kansas State University, Manhattan, Kansas, USA
*
Dept. of Biostatistics 306H, University of North Carolina, Chapel Hill, NC 27514, USA

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Departures from the usual human brain asymmetry, manifested in unusual laterality of motor dominance and/or speech representation, seem to have some genetic basis, and have been found associated with: schizophrenia, epilepsy, alcoholism, dyslexia, dysphasia, autism, and mental retardation. This can also derive from embryonic disturbances, as evidenced by excessive association with: first births, late births, birth difficulties, and twinning. MZ twins develop from embryos which have often split after at least some commitments to the cellular development of bilateral symmetry have been made. The effects of such a split are visibly recorded in mirror-imaging, in tooth emergence patterns, in shapes of mouth, nostrils, eyes, and ears, in hairwhorl placement and pattern. Brainfunction laterality is also found to be subject to mirror-imaging.

Data from the 1972 publication of the Gottesman and Shields genetic twin study of schizophrenia serve to illustrate the power of the neglected embryonic discriminator: Fully one-third of their MZ schizophrenic sample {nearly ten times the best population estimate) were characterized as lefthanded or ambidextrous. If the sample is divided between pairs with and without any sign of laterality disturbance, the results are very strikingly altered. The pairs with no sign of laterality disturbance are 88% concordant, whereas unusual laterality pairs are 24% concordant. Several severity indicators are in excess, by ratios of 2 to 10-fold, among the RH pairs. Nuclear subtypes are (2.5) times as frequent, and schizoid premorbid personalities are twice as frequent, among the RH pairs.

Type
6. Twin Studies in Behavior Genetics
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 25 , Issue 1 , January 1976 , pp. 244 - 248
Copyright
Copyright © The International Society for Twin Studies 1976

References

REFERENCES

Boklage, C.E. 1974. The embryogenesis of schizophrenia. Manuscript.Google Scholar
Bulmer, M.G. 1970. The Biology of Twinning in Man. Oxford: Clarendon Press.Google Scholar
Davies, J., Chazen, E., Nance, W.E. 1971. Symmelia in one of monozygotic twins. Teratology, 4: 367–378.Google Scholar
Falek, A. 1959. Handedness: a family study. Am. J. Hum. Genet., 11: 52–62.Google Scholar
Gottesman, I.I., Shields, J. 1972. Schizophrenia and Genetics: A Twin-Study Vantage Point. Ndew York and London: Academic Press.Google Scholar
Hamilton, W.J., Mossman, H.W. 1972. Human Embryology [4th Ed.]. Baltimore: The Williams and Wilkins Co.Google Scholar
Nance, W.E. 1969. Anencephaly and spina bifida: a possible example of cytoplasmic inheritance in man. Nature, 224: 373–375.Google Scholar
Satz, P., Fennell, E., Reilly, C. 1968. Handedness and predicted speech laterality in identical twins. Personally communicated unpublished report. Cited in Satz, P., Achenbach, K. Fennell, E. 1967. Correlations between assessed manual laterality and predicted speech laterality in a normal population. Neuropsychologia, 5: 295–310.Google Scholar