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Perseveration in schizophrenic patients: a neuropsychological approach for research

Published online by Cambridge University Press:  18 September 2015

M.G. Lanser ,
B.A. Ellenbroek ,
A.R. Cools  and
F.G. Zitman
M.G. Lanser*
Affiliation:
Department of Psychoneuropharmacology, Katholieke Universiteit Nijmegen
B.A. Ellenbroek
Affiliation:
Department of Psychoneuropharmacology, Katholieke Universiteit Nijmegen
A.R. Cools
Affiliation:
Department of Psychoneuropharmacology, Katholieke Universiteit Nijmegen
F.G. Zitman
Affiliation:
Department of Psychiatry, St. Radboud Ziekenhuis, Nijmegen
*
Department of Psychoneuropharmacology, Katholieke Universiteit Nijmegen, Postbus 9101, 6500 HB Nijmegen, The Netherlands
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Summary

Perseveration is a core symptom of schizophrenia, the cause, however, is unknown. It has been shown that for people with frontal lobe lesions, perseveration can be explained with a set-maintenance problem. Perseveration in Parkinson's disease can be explained with problems shifting from one set to another without cues (set-shifting). These disorders can be distinguished using a two-choice task and the Wisconsin Card Sorting Test, that is analysed in phases. Analogs of these tests can be used in animal research. By adding an animal part to the human research, more insight can be gained into the role of specific brain areas in set-maintenance and set-shifting.

Keywords

schizophreniaperseverationWisconsin Card sorting Testtwo-choice taskset-maintenanceset-shifting
Type
Articles
Information
Acta Neuropsychiatrica , Volume 12 , Issue 1 , March 2000 , pp. 27 - 31
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2000

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References

Literatuur

1.Bleuler, E. Lehrbuch der psychiatrie. Berlin, Julius Springer, 1918.CrossRefGoogle Scholar
2.Kraepelin, E. Dementia praecox. Chicago, Med Book, 1919.Google Scholar
3.Frith, ChD, Done, DJ. Stereotyped responding by schizophrenic patients on a two-choice guessing task. Psychol Med 1983;13:779–786.CrossRefGoogle ScholarPubMed
4. DSM-III-R. Diagnostic and statistical manual of mental disorders. Washington, DC, American Psychiatric Association, 1987.Google Scholar
5.Frith, CD, Done, DJ. Stereotyped behaviour in madness and in health. In: Cooper, SJ, Dourish, CT. Neurobiology of stereotyped behaviour. Oxford, Clarendon Press, 1990.Google Scholar
6.Heaton, RK, Chelune, GJ. Talley, JLet al.Wisconsin Card Sorting Test Manual. Odessa (FL), Psychological Assessment Resources, 1993.Google Scholar
7.Grant, DA, Berg, EA. A behavioral analysis of degree of reinforcement and ease of shifting to new responses in a Weigl-type card-sorting problem. J Exp Psychol 1948;38:404–411.CrossRefGoogle Scholar
8.Goldstein, G, Beers, SR, Shemansky, WJ. Neuropsychological differences between schizophrenic patients with heterogeneous Wisconsin Card Sorting Test performance. Schizophr Res 1996;21:13–18.CrossRefGoogle ScholarPubMed
9.Basso, MR, Nasrallah, HAet al.Neuropsychological correlates of negative, disorganised and psychotic symptoms in schizophrenia. Schizophr Res 1998;31:99–111.CrossRefGoogle ScholarPubMed
10.Bornstein, RA, Nasrallah, HA, Olson, SCet al.Neuropsychological deficit in schizophrenic subtypes: paranoid, nonparanoid, and schizoaffective subgroups. Psychiatr Res 1997;31:15–24.CrossRefGoogle Scholar
11.Seltzer, J, Conrad, C, Cassens, G. Neuropsychological profiles in schizophrenia: paranoid versus undifferentiated distinctions. Schizophr Res 1997;23:131–138.CrossRefGoogle ScholarPubMed
12.Does, van der, AJW, Bosch van den, RJ. What determines Wisconsin Card Sorting performance in schizophrenia? Clin Psychol Rev 1992;12:567–583.CrossRefGoogle Scholar
13.Stuss, DT, Benson, DF. The frontal lobes. New York, Raven Press, 1986.Google Scholar
14.Eslinger, PJ, Grattan, LM. Frontal lobe and fronto-striatal substrates for different forms of human cognitive flexibility. Neuropsychologia 1993;31:17–28.CrossRefGoogle Scholar
15.Shallice, T. The allocation of processing resources: higher-level control. In: Shallice, T. From neuropsychology to mental structure. Cambridge: Cambridge Univ Press, 1988.CrossRefGoogle Scholar
16.Fuster, JM. The prefrontal cortex. New York, Raven Press, 1980.Google Scholar
17.Cools, AR, Berger, HJC, Buytenhuijs, EL, et al.Manifestations of switching disorders in animals and man with dopamine deficits in A10 and/or A9 circuitries. In: Wolters, E, Scheltens, P (ed). Mental Dysfunction in Parkinson's Disease. Amsterdam, Vrije Universiteit, 1993.Google Scholar
18.Hsieh, S, Lee, C-Y, Tai, C-T. Set-shifting aptitude in Parkinson's disease: external versus internal cues. Psychological Reports 1995;77:339–349.CrossRefGoogle ScholarPubMed
19.Frith, CD. The cognitive neuropsychology of schizophrenia. Hove (UK), Lawrence Erlbaum, 1992.Google Scholar
20.Cools, ARRole of the neostriatal dopaminergic activity in sequencing and selecting behavioural strategies: facilitation of processes involved in selecting the best strategy in a stressful situation. Behav Brain Res 1980;1:361–378.CrossRefGoogle Scholar
21.Bos, R van den, Cools, AR. The involvement of the nucleus accumbens in the ability of rats to switch to cue-directed behaviours. Life Sci 1989;44:1697–1704.Google ScholarPubMed
22.Lyon, N, Mesjholm, B, Lyon, M. Stereotyped responding by schizophrenic outpatients: cross-cultural confirmation of perseverative switching on a two-choice task. J Psychiatr Res 1986;20 137–150.CrossRefGoogle ScholarPubMed
23.Lyon, N, Gerlach, J. Perseverative structuring of responses by schizophrenic and affective disorder patients. J Psychiatr Res 1988;22:261–277.CrossRefGoogle ScholarPubMed
24.Spaendonck, KPM van, Berger, HJC, Horstink, MWIM, et al.Card sorting performance in Parkinson's disease: a comparison between acquisition and shifting performance. J Clin Exp Neuropsych 1995;17:918–925.CrossRefGoogle ScholarPubMed
25.Gold, JM, Carpenter, C, et al.Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia. Arch Gen Psychiatry 1997;54:159–165.CrossRefGoogle ScholarPubMed
26.Evenden, JL, Robbins, TW. Increased response switching, perseveration and perseverative switching following d-amphetamine in the rat. Psychopharmacology 1983;80:67–73.CrossRefGoogle ScholarPubMed
27.Robbins, TW, Watson, BA. Effects of d-amphetamine on response repetition and ‘win-stay’ behaviour in rat. In: Bradshaw, CM, Szabadi, , Lowe, CF. Quantification of steady-state operant behaviour. Amsterdam, Elsevier - North-Holland Biomedical Press, 1981.Google Scholar
28.Bos, R van den, Charria Ortiz, GA, Cools, AR. Injections of the NMDA-antagonist D-2-amino-7-phosphonoheptanoic acid (AP-7) into the nucleus accumbens of rats enhance switching between cue-directed behaviours in a swimming test procedure. Behav Brain Res 1992;48:165–170.Google Scholar