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Association of NKAPL, TSPAN18, and MPC2 gene variants with schizophrenia based on new data and a meta-analysis in Han Chinese

Published online by Cambridge University Press:  27 July 2016

Zhen Li ,
Tingting Shen ,
Ran Xin ,
Baoyun Liang ,
Juan Jiang ,
Weijun Ling ,
Bo Wei  and
Li Su
Zhen Li
Affiliation:
School of Public Health, Guangxi Medical University, Nanning, Guangxi, China Education Department, Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
Tingting Shen
Affiliation:
First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China
Ran Xin
Affiliation:
Chinese Center for Disease Control and Prevention, Nanning, Guangxi, China
Baoyun Liang
Affiliation:
First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China
Juan Jiang
Affiliation:
School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
Weijun Ling
Affiliation:
School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
Bo Wei*
Affiliation:
School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
Li Su*
Affiliation:
School of Public Health, Guangxi Medical University, Nanning, Guangxi, China Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Nanning, Guangxi, China
*
Bo Wei, School of Public Health of Guangxi Medical University, 22 Shuangyong Road, Nanning, Guangxi 530021, China. Tel: +867 715 358 847; Fax: +867 715 350 823; E-mail: weibogx@163.com
Li Su, School of Public Health of Guangxi Medical University, 22 Shuangyong Road, Nanning, Guangxi 530021, China; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Nanning, Guangxi 530021, China. Tel: +861 387 889 0526; Fax: +867 715 350 823; E-mail: suli2018@hotmail.com
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Abstract

Background

Schizophrenia (SZ) is suggested to be a complex polygenetic disorder with high heritability. Genome-wide association studies have found that the rs1635, rs11038167, and rs10489202 polymorphisms are associated with SZ in Han Chinese. However, results of validation studies are inconsistent. This study aimed to test the association between the NKAPL rs1635, TSPAN18 rs11038167, and MPC2 rs10489202 polymorphisms and SZ in a Chinese population.

Methods

This study contained 700 unrelated SZ patients (300 Zhuang and 400 Han) and 700 gender- and age-matched controls (300 Zhuang and 400 Han). The polymorphisms in TSPAN18 (rs11038167), NKAPL (rs1635), and MPC2 (rs10489202) were genotyped using the Sequenom MassARRAY method. Statistical analyses were performed with PLINK program and SPSS l6.0 for Windows. STATA11.1 was used for meta-analysis.

Results

No statistically significant difference was found in different allele and genotype frequencies of rs1635, rs11038167, and rs10489202 between SZ cases and controls of Zhuang and Han ethnicities and the total samples (all p>0.05). Further meta-analysis suggested that single-nucleotide polymorphism rs10489202 was significantly associated with SZ in a Han Chinese population (pOR=0.002).

Conclusions

Our case–control study failed to validate the significant association of NKAPL rs1635, TSPAN18 rs11038167, and MPC2 rs10489202 polymorphisms with SZ susceptibility in the southern Zhuang or Han Chinese population. However, meta-analysis showed a significant association between MPC2 variant rs10489202 and SZ susceptibility in Han Chinese.

Keywords

association studiesMPC2NKAPLschizophreniaTSPAN18
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 29 , Issue 2 , April 2017 , pp. 87 - 94
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Copyright
© Scandinavian College of Neuropsychopharmacology 2016 

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Footnotes

†

First co-author.

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