1998. Metabolic rate in the right amygdala predicts negative affect in depressed patients. Neuroreport
9, 3301–7., , , et al.
2005. Prefrontal and striatal activation during sequence learning in geriatric depression. Biol Psychiatry
58, 290–6., , , , , III and
2002. Frontostriatal and limbic dysfunction in late-life depression. Am J Geriatr. Psychiatry
1997. “Vascular depression” hypothesis. Arch Gen Psychiatry
54, 915–22., , , , and
2005a. Activity and connectivity of brain mood regulating circuit in depression: A functional magnetic resonance study. Biol Psychiatry
57, 1079–88., , , et al.
2005b. Antidepressant effect on connectivity of the mood-regulating circuit: An fMRI study. Neuropsychopharmacology
30, 1334–44., , , et al.
2007. Reciprocal effects of antidepressant treatment on activity and connectivity of the mood regulating circuit: An fMRI study. J Neuropsychiatry Clin Neurosci
19, 274–82., , , and
2002. SPECT neuropsychological activation procedure with the Verbal Fluency Test in attempted suicide patients. Nucl Med Commun
23, 907–16., , , et al.
1992. Cognitive functions in major depression. J Affect Disord
25, 21–30., , , , and
2004. Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: An MRI-based parcellation of the prefrontal cortex. Am J Psychiatry
161, 99–108., , , et al.
2003. Working memory and prefrontal cortex dysfunction: Specificity to schizophrenia compared with major depression. Biol Psychiatry
53, 376–84., , and
1989. Reduction of prefrontal cortex glucose metabolism common to three types of depression. Arch Gen Psychiatry
46, 243–50., , , et al.
1985. Cerebral metabolic rates for glucose in mood disorders. Arch Gen Psychiatry
42, 441–7., , , et al.
1996. Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed. Psychol Med
26, 591–603., and
1979. Cognitive Therapy of Depression. New York, NY: Guilford., , and
2004. Normalization of enhanced fear recognition by acute SSRI treatment in subjects with a previous history of depression. Am J Psychiatry
161, 166–8., , and
1995. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Res Med
34, 537–41., , and
1994. Frontal and parietal metabolic disturbances in unipolar depression. Biol Psychiatry
36, 381–8., , , et al.
2002. Predictors of mood response to acute tryptophan depletion. A reanalysis. Neuropsychopharmacology
27, 852–61., , , et al.
1999. Depressed patients' perceptions of facial emotions in depressed and remitted states are associated with relapse: A longitudinal study. J Nerv Mental Dis
187, 595–602., and
2008. Ventromedial prefrontal cortex processing during emotional evaluation in late-life depression: A longitudinal functional magnetic resonance imaging study. Biol Psychiatry
64, 349–55., , , and
2001. Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: Preliminary findings. Arch Gen Psychiatry
58, 631–40., , , et al.
2001. Neuropsychology of fear and loathing. Nat Rev Neurosci
2, 352–63., and
2005. Amygdala reactivity to emotional faces predicts improvement in major depression. Neuroreport
16, 1267–70., , , et al.
2002. Foundation for the NIMH strategic plan for mood disorders research. Biol Psychiatry
52, 455–6. and
2008. Functional coupling of the amygdala in depressed patients treated with antidepressant medication. Neuropsychopharmacology
33, 1909–18., , , et al.
1995. Anosognosia, intrusions and “frontal” functions in Alzheimer's disease and depression. Neuropsychologia
33, 247–59., , and
2003. The neural substrates of affective processing in depressed patients treated with venlafaxine. Am J Psychiatry
160, 64–75., , and
1999. Prefrontal cortical–amygdalar metabolism in major depression. Ann N Y Acad Sci
2002. Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism. Eur Neuropsychopharmacol
12, 527–44., and
2008. Brain structural and functional abnormalities in mood disorders: Implications for neurocircuitry models of depression. Brain Struct Funct
213, 93–118., and
1997. Subgenual prefrontal cortex abnormalities in mood disorders. Nature
386, 824–7., , , et al.
1992. A functional anatomical study of unipolar depression. J Neurosci
12, 3628–41., , , , and
1998. A voxel-based analysis of cerebral perfusion in dementia and depression of old age. Neuroimage
7, 199–208., , , and
1997. Prefrontal dysfunction in depressed patients performing a complex planning task: A study using positron emission tomography. Psychol Med
27, 931–42., , , et al.
1998. Abnormal neural response to feedback on planning and guessing tasks in patients with unipolar depression. Psychol Med
28, 559–71., , , and
2002. The neural basis of mood-congruent processing biases in depression. Arch Gen Psychiatry
59, 597–604., , and
2006. Lack of ventral striatal response to positive stimuli in depressed versus normal subjects. Am J Psychiatry
163, 1784–90., , , et al.
2003. Diagnosis and definition of treatment-resistant depression. Biol Psychiatry
2008. Brain stimulation techniques for the treatment of depression and other psychiatric disorders. Austral Psychiatry
2008a. A meta-analytic study of changes in brain activation in depression. Hum Brain Mapp
29, 683–95., , and
2008b. An fMRI study of prefrontal brain activation during multiple tasks in patients with major depressive disorder. Hum Brain Mapp
29, 490–501., , , et al.
2006. Reward-related decision-making in pediatric major depressive disorder: An fMRI study. J Child Psychol Psychiatry
47, 1031–40., , , et al.
2008a. Pattern classification of sad facial processing: Toward the development of neurobiological markers in depression. Biol Psychiatry
63, 656–62., , , et al.
2004. Attenuation of the neural response to sad faces in major depression by antidepressant treatment: A prospective, event-related functional magnetic resonance imaging study. Arch Gen Psychiatry
61, 877–89., , , et al.
2007. Neural responses to happy facial expressions in major depression following antidepressant treatment. Am J Psychiatry
164, 599–607., , , et al.
2008b. Neural responses to sad facial expressions in major depression following cognitive behavioral therapy. Biol Psychiatry
64, 505–12., , , et al.
1997. Blunted left cingulate activation in mood disorder subjects during a response interference task (the Stroop). J Neuropsychiatry Clin Neurosci
9, 55–63., , , , and
2004. The regional cerebral blood flow changes in major depressive disorder with and without psychotic features. Prog Neuropsychopharmacol Biol Psychiatry
28, 1015–21., , , and
2008. Neuroimaging and depression: Current status and unresolved issues. Curr Dir Psychol Sci
17, 159–63. and
1989. Depression and marital functioning: An examination of specificity of gender differences. J Abnorm Psychol
98, 23–30. and
2007. Resting-state functional connectivity in major depression: Abnormally increased contributions from subgenual cingulate cortex and thalamus. Biol Psychiatry
62, 429–37., , , et al.
1992. Facial emotion discrimination: II. Behavioral findings in depression. Psychiatry Res
42, 241–51., , , , and
2001. Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function. Proc Natl Acad Sci U S A
98, 4259–64., , and .
2002. The amygdala response to emotional stimuli: A comparison of faces and scenes. Neuroimage
17, 317–23., , , and .
2006. Toward constructing an endophenotype strategy for bipolar disorders. Biol Psychiatry
60, 93–105., , , and
2004. Discovering endophenotypes for major depression. Neuropsychopharmacology
29, 1765–81., , and
2008. Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjects. Arch Gen Psychiatry
65, 521–31., , , et al.
2000. The distributed human neural system for face perception. Trends Cognit Sci
4, 223–33., and
1995. Subcortical hyperintensities on magnetic resonance imaging: Clinical correlates and prognostic significance in patients with severe depression. Biol Psychiatry
37, 151–60., , , , and
2009. Neural markers of symptomatic improvement during antidepressant therapy in severe depression: subgenual cingulate and visual cortical responses to sad, but not happy, facial stimuli are correlated with changes in symptom score. J Psychopharmacol
23, 775–88., , , , and
2005a. A double dissociation of ventromedial prefrontal cortical responses to sad and happy stimuli in depressed and healthy individuals. Biol Psychiatry
58, 495–503., , , and
2005b. The neural correlates of anhedonia in major depressive disorder. Biol Psychiatry
58, 843–53., , , and
2007. Differences in brain glucose metabolism between responders to CBT and venlafaxine in a 16-week randomized controlled trial. Am J Psychiatry
164, 778–88., , , et al.
2003. The epidemiology of major depressive disorder: Results from the National Comorbidity Survey Replication (NCS-R). JAMA
289, 3095–105., , , et al.
2002. Regional cerebral glucose utilization in patients with a range of severities of unipolar depression. Biol Psychiatry
51, 237–52., , , et al.
2003. Regional cerebral blood flow in vascular depression assessed by 123I-IMP SPECT. J Nippon Med Sch
70, 321–6., , , et al.
2008. Neural responses to monetary incentives in major depression. Biol Psychiatry
63, 686–92., , , and
2003. Differential impairments of facial affect priming in subjects with acute or partially remitted major depressive episodes. J NervMental Dis
191, 175–81., and
1994. Can state and trait variables be disentangled? A methodological framework for psychiatric disorders. Psychiatry Res
52, 55–69., , , and
2002. Biomarkers in psychiatry: methodological issues. Am J Geriatr Psychiatry
10, 653–9., and
2003. Neural abnormalities during cognitive generation of affect in treatment-resistant depression. Biol Psychiatry
54, 777–91., , , et al.
2001. International Affective Picture System (IAPS): Instruction Manual and Affective Ratings. Technical Report A-5 The Center for Research in Psychophysiology, University of Florida., and
2004. Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression. Biol Psychiatry
55, 578–87., , , et al.
1973. Concept of social skills with special reference to the behavior of depressed persons. J Consult Clin Psychol
40, 304–13. and
2002. Unmasking disease-specific cerebral blood flow abnormalities: Mood challenge in patients with remitted unipolar depression. Am J Psychiatry
159, 1830–40., , , and
2008. Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression. Biol Psychiatry
64, 461–7., , , , and
2008. Affective modulation of anterior cingulate cortex in young people at increased familial risk of depression. Br J Psychiatry
192, 356–61., , , , and
2001. Brain blood flow changes in depressed patients treated with interpersonal psychotherapy or venlafaxine hydrochloride: Preliminary findings. Arch Gen Psychiatry
58, 641–8., , , and
1990. Left prefrontal glucose hypometabolism in the depressed state: A confirmation. Am J Psychiatry
147, 1313–7., , , et al.
2007. Emotional bias and waking salivary cortisol in relatives of patients with major depression. Psychol Med
37, 403–10., and
2007. Prefrontal hyperactivation during working memory task in untreated individuals with major depressive disorder. Mol Psychiatry
12, 158–66., , , et al.
1997. Limbic–cortical dysregulation: A proposed model of depression. J Neuropsychiatry Clin Neurosci
1997. Cingulate function in depression: A potential predictor of treatment response. Neuroreport
8, 1057–61., , , et al.
1999. Reciprocal limbic–cortical function and negative mood: Converging PET findings in depression and normal sadness. Am J Psychiatry
156, 675–82., , , , and
2005. Deep brain stimulation for treatment-resistant depression. Neuron
45, 651–60., , , et al.
2003. A parametric manipulation of factors affecting task-induced deactivation in functional neuroimaging. J Cognit Neurosci
15, 394–408., , and
2001. Wisconsin Card Sorting revisited: Distinct neural circuits participating in different stages of the task identified by event-related functional magnetic resonance imaging. J Neurosci
21, 7733–41., , , and
2008. Amygdala and nucleus accumbens activation to emotional facial expressions in children and adolescents at risk for major depression. Am J Psychiatry
165, 90–8., , , et al.
1996. Frontal lobe dysfunction and depression: Relation with the endogenous nature of the depression. Encephale
22, 47–51., , , , and
1999. Recurrence after recovery from major depressive disorder during 15 years of observational follow-up. Am J Psychiatry
156, 1000–6., , , et al.
2004. Prognostic value of frontal functional neuroimaging in late-onset severe major depression. Br J Psychiatry
184, 306–11., , , et al.
2004. Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls. Arch Gen Psychiatry
61, 765–73., , , et al.
1999. Changes in forebrain function from waking to REM sleep in depression: Preliminary analyses of [18F]FDG PET studies. Psychiatry Res
91, 59–78., , , et al.
2003. Attenuated left prefrontal activation during a verbal fluency task in patients with depression. Neuropsychobiology
47, 21–6., , , and
2005. Relationship between regional cerebral blood flow and separate symptom clusters of major depression: A single photon emission computed tomography study using statistical parametric mapping. Neurosci Lett
384, 265–70., , , et al.
1993. Differences between depressed and nondepressed individuals in the recognition of and response to facial cues. J Abnorm Psychol
102, 358–68. and
2003a. Neurobiology of emotion perception I: The neural basis of normal emotion perception. Biol Psychiatry
54, 504–14., , and
2003b. Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biol Psychiatry
54, 515–28., , and
2006. Redefining bipolar disorder: Toward DSM-V. Am J Psychiatry
163, 1135–6. and
2008. A neural model of voluntary and automatic emotion regulation: Implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Mol Psychiatry
13, 833–57., and
1997. A specific neural substrate for perceiving facial expressions of disgust. Nature
389, 495–8., , , et al.
2002. The neural system that bridges reward and cognition in humans: An fMRI study. Proc Natl Acad Sci U S A
99, 5669–74., , , et al.
2001. Inaugural Article: A default mode of brain function. Proc Natl Acad Sci U S A
98, 676–82., , , , and
1997. Selective aging of the human cerebral cortex observed in vivo: Differential vulnerability of the prefrontal gray matter. Cerebral Cortex
7, 268–82., , , et al.
2006. Increased amygdala activity during successful memory encoding in adolescent major depressive disorder: An fMRI study. Biol Psychiatry
60, 966–73., , , et al.
2006. Limbic over-activity in depression during preserved performance on the n-back task. Neuroimage
29, 203–15., and
1996. MRI and neuropsychological differences in early- and late-life-onset geriatric depression. Neurology
46, 1567–74., , , et al.
2008. Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology
33, 368–77., , , et al.
2001. Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: An fMRI study. Biol Psychiatry
50, 651–8., , , , and
2002. Can't shake that feeling: Event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals. Biol Psychiatry
51, 693–707., , , and
2006. Use of fMRI to predict recovery from unipolar depression with cognitive behavior therapy. Am J Psychiatry
163, 735–8., and E.
2007. Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: Related and independent features. Biol Psychiatry
61, 198–209., , , and
1997. Recovery from major depression. A 10-year prospective follow-up across multiple episodes. Arch Gen Psychiatry
54, 1001–06., , , et al.
1998. Neural structures associated with recognition of facial expressions of basic emotions. Proc R Soc Lond B Biol Sci
265, 1927–31., , and
2002. Adult clinical neuropsychology: Lessons from studies of the frontal lobes. Annu Rev Psychol
53, 401–33. and
2005. A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder. Biol Psychiatry
57, 201–09., , , et al.
2003. A preferential increase in the extrastriate response to signals of danger. Neuroimage
19, 1317–28., , , et al.
2004. Recognition accuracy and response bias to happy and sad facial expressions in patients with major depression. Neuropsychology
18, 212–8., , , , and
2001. Detection of facial expressions of emotions in depression. Percept Motor Skills
92, 857–68., and
1988. Cognitive vulnerability to persistent depression. Cogn Emot
2001. Amygdala response to fearful faces in anxious and depressed children. Arch Gen Psychiatry
58, 1057–63., , , et al.
2005. Functional neuroanatomical substrates of altered reward processing in major depressive disorder revealed by a dopaminergic probe. Arch Gen Psychiatry
62, 1228–36., , , et al.
2001. Global burden of depressive disorders and future projections. In and (Eds.) Depression: Social and Economic Timebomb. London: BMJ, pp. 31–43. and
2006. Neuroimaging in late-life depression. Int Rev Psychiatry
18, 443–51. and
1997. A preliminary profile of neuropsychological deficits associated with major depression. J Clin Exp Neuropsychol
2002. The Danish PET/depression project: Clinical symptoms and cerebral blood flow. A regions-of-interest analysis. Acta Psychiatr Scand
106, 35–44., , , et al.
2007. A longitudinal functional magnetic resonance imaging study of verbal working memory in depression after antidepressant therapy. Biol Psychiatry
62, 1236–43., , , et al.
1999. The World Health Report 1999: Making a Difference. Geneva: World Health Organization..
2008. Regional homogeneity in depression and its relationship with separate depressive symptom clusters: A resting-state fMRI study. J Affect Disord
115, 430–8., , , and
1998. On the nature and pattern of neurocognitive function in major depressive disorder. Neuropsychiatry, Neuropsychol Behav Neurol
11, 111–9., and
2004. Regional homogeneity approach to fMRI data analysis. NeuroImage
22, 394–400., , , and
1991. Independence of memory functions and emotional behavior: Separate contributions of the hippocampal formation and the amygdala. Hippocampus
1, 207–20., , and