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Chapter 42 - Disseminated Intravascular Coagulation

from Section 5 - Disorders Involving Abnormal Coagulation

Published online by Cambridge University Press:  15 June 2018

Louis Caplan
Affiliation:
Beth Israel-Deaconess Medical Center, Boston
José Biller
Affiliation:
Loyola University Stritch School of Medicine, Chicago
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Print publication year: 2018

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References

Hardaway, R. M. Disseminated intravascular coagulation syndromes. Arch. Surg. Chic. Ill. 1960 83, 842–50 (1961).Google Scholar
Goodnight, S. H. et al. Defibrination after brain-tissue destruction: A serious complication of head injury. N. Engl. J. Med. 290, 1043–7 (1974).CrossRefGoogle ScholarPubMed
Gando, S., Nanzaki, S., Sasaki, S. & Kemmotsu, O. Significant correlations between tissue factor and thrombin markers in trauma and septic patients with disseminated intravascular coagulation. Thromb. Haemost. 79, 1111–15 (1998).Google Scholar
Gando, S. Disseminated intravascular coagulation in trauma patients. Semin. Thromb. Hemost. 27, 585–92 (2001).Google Scholar
García-Avello, A. et al. Degree of hypercoagulability and hyperfibrinolysis is related to organ failure and prognosis after burn trauma. Thromb. Res. 89, 5964 (1998).CrossRefGoogle ScholarPubMed
Barbui, T. & Falanga, A. Disseminated intravascular coagulation in acute leukemia. Semin. Thromb. Hemost. 27, 593604 (2001).CrossRefGoogle ScholarPubMed
Arai, A. et al. Cardiac malignant pheochromocytoma with bone metastases. Intern. Med. Tokyo Jpn. 37, 940–4 (1998).Google ScholarPubMed
Letsky, E. A. Disseminated intravascular coagulation. Best Pract. Res. Clin. Obstet. Gynaecol. 15, 623–44 (2001).CrossRefGoogle ScholarPubMed
Hossain, N. & Paidas, M. J. Disseminated intravascular coagulation. Semin. Perinatol. 37, 257–66 (2013).Google Scholar
Breakwell, L. M., Getty, C. J., & Austin, C. Disseminated intravascular coagulation in elective primary total hip replacement. J. Arthroplasty 14, 239–42 (1999).Google Scholar
Asherson, R. A. The catastrophic antiphospholipid syndrome, 1998. A review of the clinical features, possible pathogenesis and treatment. Lupus 7, S5562 (1998).CrossRefGoogle ScholarPubMed
Katsaros, D. & Grundfest-Broniatowski, S. Successful management of visceral Klippel–Trenaunay–Weber syndrome with the antifibrinolytic agent tranexamic acid (cyclocapron): A case report. Am. Surg. 64, 302–4 (1998).Google ScholarPubMed
Persoons, M. C., Stals, F. S., van dam Mieras, M. C., & Bruggeman, C. A. Multiple organ involvement during experimental cytomegalovirus infection is associated with disseminated vascular pathology. J. Pathol. 184, 103–9 (1998).Google Scholar
Lifshitz, M., Kapelushnik, J., Ben-Harosh, M., & Sofer, S. Disseminated intravascular coagulation after Cerastes vipera envenomation in a 3-year-old child: A case report. Toxicon Off. J. Int. Soc. Toxinology 38, 1593–8 (2000).CrossRefGoogle Scholar
Bey, T. A. et al. Loxosceles arizonica bite associated with shock. Ann. Emerg. Med. 30, 701–3 (1997).Google Scholar
Jung, J. W. et al. A fatal case of intravascular coagulation after bee sting acupuncture. Allergy Asthma Immunol. Res. 4, 107–9 (2012).Google Scholar
Dhanapriya, J. et al. Acute kidney injury and disseminated intravascular coagulation due to mercuric chloride poisoning. Indian J. Nephrol. 26, 206 (2016).Google Scholar
Felcher, A. et al. Disseminated intravascular coagulation and status epilepticus. Neurology 51, 629–31 (1998).CrossRefGoogle ScholarPubMed
Bick, R. L. Disseminated intravascular coagulation. Hematol. Oncol. Clin. North Am. 6, 1259–85 (1992).Google Scholar
Gando, S., Levi, M., & Toh, C.-H. Disseminated intravascular coagulation. Nat. Rev. Dis. Primer 2, 16037 (2016).CrossRefGoogle ScholarPubMed
Dhainaut, J.-F., Macias, W. L., & Nelson, D. R. Would patients with more subtle signs of coagulopathy have benefited from treatment with activated protein C? Crit. Care Med. 33, 1670–1 (2005).Google Scholar
Taylor, F. B. et al. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb. Haemost. 86, 1327–30 (2001).CrossRefGoogle Scholar
Favaloro, E. J. & Adcock, D. M. Standardization of the INR: How good is your laboratory’s INR and can it be improved? Semin. Thromb. Hemost. 34, 593603 (2008).CrossRefGoogle ScholarPubMed
Gando, S. et al. A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: Comparing current criteria. Crit. Care Med. 34, 625–31 (2006).Google Scholar
Prechel, M. & Walenga, J. M. The laboratory diagnosis and clinical management of patients with heparin-induced thrombocytopenia: An update. Semin. Thromb. Hemost. 34, 8696 (2008).Google Scholar
Selleng, K., Selleng, S., & Greinacher, A. Heparin-induced thrombocytopenia in intensive care patients. Semin. Thromb. Hemost. 34, 425–38 (2008).CrossRefGoogle ScholarPubMed
Schwartzman, R. J. & Hill, J. B. Neurologic complications of disseminated intravascular coagulation. Neurology 32, 791–7 (1982).Google Scholar
Shebuski, R. J. & Kilgore, K. S. Role of inflammatory mediators in thrombogenesis. J. Pharmacol. Exp. Ther. 300, 729–35 (2002).CrossRefGoogle ScholarPubMed
Wada, H. et al. Hemostatic molecular markers before the onset of disseminated intravascular coagulation. Am. J. Hematol. 60, 273–8 (1999).Google Scholar
Favaloro, E. J. Laboratory testing in disseminated intravascular coagulation. Semin. Thromb. Hemost. 36, 458–67 (2010).Google Scholar
Levi, M. & van der Poll, T. The role of natural anticoagulants in the pathogenesis and management of systemic activation of coagulation and inflammation in critically ill patients. Semin. Thromb. Hemost. 34, 459–68 (2008).Google Scholar
de Jonge, E., van der Poll, T., Kesecioglu, J. & Levi, M. Anticoagulant factor concentrates in disseminated intravascular coagulation: Rationale for use and clinical experience. Semin. Thromb. Hemost. 27, 667–74 (2001).Google Scholar
Naidech, A. M. & Kumar, M. A., and the participants in the International Multidisciplinary Consensus Conference on Multimodality Monitoring. Monitoring of hematological and hemostatic parameters in neurocritical care patients. Neurocrit. Care 21, 168–76 (2014).Google Scholar
Johansson, P. I., Stensballe, J., Vindeløv, N., Perner, A., & Espersen, K. Hypocoagulability, as evaluated by thromboelastography, at admission to the ICU is associated with increased 30-day mortality. Blood Coagul. Fibrinolysis 21, 168–74 (2010).CrossRefGoogle Scholar
Park, M. S. et al. Thromboelastography as a better indicator of hypercoagulable state after injury than prothrombin time or activated partial thromboplastin time. J. Trauma 67, 266–76 (2009).Google ScholarPubMed
Bakhtiari, K., Meijers, J. C. M., de Jonge, E., & Levi, M. Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation. Crit. Care Med. 32, 2416–21 (2004).Google Scholar
Gando, S. et al. Evaluation of new Japanese diagnostic criteria for disseminated intravascular coagulation in critically ill patients. Clin. Appl. Thromb. Off. J. Int. Acad. Clin. Appl. Thromb. 11, 71–6 (2005).Google Scholar
Sivula, M., Tallgren, M., & Pettilä, V. Modified score for disseminated intravascular coagulation in the critically ill. Intensive Care Med. 31, 1209–14 (2005).Google Scholar
Cauchie, P. et al. Diagnosis and prognosis of overt disseminated intravascular coagulation in a general hospital – meaning of the ISTH score system, fibrin monomers, and lipoprotein-C-reactive protein complex formation. Am. J. Hematol. 81, 414–19 (2006).Google Scholar
Umemura, Y. et al. Design and evaluation of new unified criteria for disseminated intravascular coagulation based on the Japanese Association for Acute Medicine criteria. Clin. Appl. Thromb. Off. J. Int. Acad. Clin. Appl. Thromb. 22, 153–60 (2016).Google Scholar
Angstwurm, M. W. A., Dempfle, C.-E., & Spannagl, M. New disseminated intravascular coagulation score: A useful tool to predict mortality in comparison with Acute Physiology and Chronic Health Evaluation II and Logistic Organ Dysfunction scores. Crit. Care Med. 34, 314–20; quiz 328 (2006).Google Scholar
Toh, C. H. & Downey, C. Performance and prognostic importance of a new clinical and laboratory scoring system for identifying non-overt disseminated intravascular coagulation. Blood Coagul. Fibrinolysis Int. J. Haemost. Thromb. 16, 6974 (2005).Google Scholar
Cartin-Ceba, R. et al. Epidemiology of critical care syndromes, organ failures, and life-support interventions in a suburban US community. Chest 140, 1447–55 (2011).CrossRefGoogle Scholar
Gando, S. et al. Natural history of disseminated intravascular coagulation diagnosed based on the newly established diagnostic criteria for critically ill patients: Results of a multicenter, prospective survey. Crit. Care Med. 36, 145–50 (2008).Google Scholar
Wheeler, A. P. & Bernard, G. R. Treating patients with severe sepsis. N. Engl. J. Med. 340, 207–14 (1999).Google Scholar
Levi, M., de Jonge, E., & van der Poll, T. Sepsis and disseminated intravascular coagulation. J. Thromb. Thrombolysis 16, 43–7 (2003).Google Scholar
Lavrentieva, A. et al. Early coagulation disorders after severe burn injury: Impact on mortality. Intensive Care Med. 34, 700–6 (2008).Google Scholar
Barret, J. P. & Gomez, P. A. Disseminated intravascular coagulation: A rare entity in burn injury. Burns J. Int. Soc. Burn Inj. 31, 354–7 (2005).Google Scholar
Singh, B. et al. Trends in the incidence and outcomes of disseminated intravascular coagulation in critically ill patients (2004–2010): A population-based study. Chest 143, 1235–42 (2013).CrossRefGoogle ScholarPubMed
Ranieri, V. M. et al. Drotrecogin alfa (activated) in adults with septic shock. N. Engl. J. Med. 366, 2055–64 (2012).Google Scholar
Murata, A., Okamoto, K., Mayumi, T., Muramatsu, K. & Matsuda, S. The recent time trend of outcomes of disseminated intravascular coagulation in Japan: An observational study based on a national administrative database. J. Thromb. Thrombolysis 38, 364–71 (2014).Google Scholar
Hoffman, M. & Monroe, D. M. A cell-based model of hemostasis. Thromb. Haemost. 85, 958–65 (2001).Google Scholar
Franco, R. F. et al. The in vivo kinetics of tissue factor messenger RNA expression during human endotoxemia: Relationship with activation of coagulation. Blood 96, 554–9 (2000).Google Scholar
Levi, M. & van der Poll, T. Inflammation and coagulation. Crit. Care Med. 38, S2634 (2010).Google Scholar
Rauch, U. et al. Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor. Blood 96, 170–5 (2000).Google Scholar
Zimmerman, G. A., McIntyre, T. M., Prescott, S. M., & Stafforini, D. M. The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis. Crit. Care Med. 30, S294301 (2002).CrossRefGoogle Scholar
Bockmeyer, C. L. et al. Inflammation-associated ADAMTS 13 deficiency promotes formation of ultra-large von Willebrand factor. Haematologica 93, 137–40 (2008).Google Scholar
Osterud, B. & Bjørklid, E. The production and availability of tissue thromboplastin in cellular populations of whole blood exposed to various concentrations of endotoxin. An assay for detection of endotoxin. Scand. J. Haematol. 29, 175–84 (1982).CrossRefGoogle ScholarPubMed
Engelmann, B. & Massberg, S. Thrombosis as an intravascular effector of innate immunity. Nat. Rev. Immunol. 13, 3445 (2013).Google Scholar
Müller, I. et al. Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets. FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol. 17, 476–8 (2003).Google Scholar
Fuchs, T. A. et al. Extracellular DNA traps promote thrombosis. Proc. Natl. Acad. Sci. USA 107, 15880–5 (2010).Google Scholar
von Brühl, M.-L. et al. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J. Exp. Med. 209, 819–35 (2012).CrossRefGoogle ScholarPubMed
Massberg, S. et al. Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases. Nat. Med. 16, 887–96 (2010).CrossRefGoogle ScholarPubMed
Franchini, M. Pathophysiology, diagnosis and treatment of disseminated intravascular coagulation: An update. Clin. Lab. 51, 633–9 (2005).Google ScholarPubMed
Lineaweaver, W., Franzini, D., Dragonetti, D., McCarley, D., & Rumley, T. Haemophilus influenzae meningitis and Waterhouse–Friderichsen syndrome in an adult. South. Med. J. 79, 1034–6 (1986).Google Scholar
Ohashi, R. et al. Acute renal failure as the presenting sign of disseminated intravascular coagulation in a patient with metastatic prostate cancer. Int. J. Nephrol. Renov. Dis. 6, 4751 (2013).Google Scholar
Bick, R. L. Disseminated intravascular coagulation: Pathophysiological mechanisms and manifestations. Semin. Thromb. Hemost. 24, 318 (1998).Google Scholar
Collins, R. C., Al-Mondhiry, H., Chernik, N. L., & Posner, J. B. Neurologic manifestations of intravascular coagulation in patients with cancer. A clinicopathologic analysis of 12 cases. Neurology 25, 795806 (1975).CrossRefGoogle Scholar
Graus, F., Rogers, L. R., & Posner, J. B. Cerebrovascular complications in patients with cancer. Medicine (Baltimore) 64, 1635 (1985).Google Scholar
Wijdicks, E. F. & Scott, J. P. Stroke in the medical intensive-care unit. Mayo Clin. Proc. 73, 642–6 (1998).CrossRefGoogle ScholarPubMed
Navi, B. B. et al. Intracerebral and subarachnoid hemorrhage in patients with cancer. Neurology 74, 494501 (2010).CrossRefGoogle ScholarPubMed
Goodnight, S. H. Bleeding and intravascular clotting in malignancy: A review. Ann. N. Y. Acad. Sci. 230, 271–88 (1974).Google ScholarPubMed
Pisoni, R., Ruggenenti, P. & Remuzzi, G. Drug-induced thrombotic microangiopathy: Incidence, prevention and management. Drug Saf. 24, 491501 (2001).Google Scholar
Nguyen, T. C. & Carcillo, J. A. Bench-to-bedside review: Thrombocytopenia-associated multiple organ failure – a newly appreciated syndrome in the critically ill. Crit. Care Lond. Engl. 10, 235 (2006).Google Scholar
Johnson, R. T. & Richardson, E. P. The neurological manifestations of systemic lupus erythematosus. Medicine (Baltimore) 47, 337–69 (1968).Google Scholar
Musio, F., Bohen, E. M., Yuan, C. M., & Welch, P. G. Review of thrombotic thrombocytopenic purpura in the setting of systemic lupus erythematosus. Semin. Arthritis Rheum. 28, 119 (1998).Google Scholar
Yasuda, S., Bohgaki, M., Atsumi, T. & Koike, T. Pathogenesis of antiphospholipid antibodies: Impairment of fibrinolysis and monocyte activation via the p38 mitogen-activated protein kinase pathway. Immunobiology 210, 775–80 (2005).Google Scholar
Galli, M. Treatment of the antiphospholipid syndrome. Auto- Immun. Highlights 5, 17 (2014).Google Scholar
Cervera, R. & Espinosa, G. Update on the catastrophic antiphospholipid syndrome and the ‘CAPS Registry’. Semin. Thromb. Hemost. 38, 333–8 (2012).Google Scholar
van Runnard Heimel, P. J. et al. A randomised placebo-controlled trial of prolonged prednisolone administration to patients with HELLP syndrome remote from term. Eur. J. Obstet. Gynecol. Reprod. Biol. 128, 187193 (2006).Google Scholar
Pijnenborg, R., Vercruysse, L., Hanssens, M. & Brosens, I. Endovascular trophoblast and preeclampsia: A reassessment. Pregnancy Hypertens. 1, 6671 (2011).CrossRefGoogle ScholarPubMed
Warkentin, T. Heparin-induced thrombocytopenia in critically ill patients. Semin. Thromb. Hemost. 41, 049–60 (2015).Google ScholarPubMed
Warkentin, T. E., Sheppard, J.-A. I., Moore, J. C., Cook, R. J., & Kelton, J. G. Studies of the immune response in heparin-induced thrombocytopenia. Blood 113, 4963–9 (2009).CrossRefGoogle ScholarPubMed
Hanly, E. J., Cohn, E. J., Johnson, J. L., & Peyton, B. D. DIC: Treatment frontiers. Curr. Surg. 59, 257–64 (2002).CrossRefGoogle ScholarPubMed
Levi, M., Toh, C. H., Thachil, J., & Watson, H. G. Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology. Br. J. Haematol. 145, 2433 (2009).Google Scholar
Wada, H. et al. Expert consensus for the treatment of disseminated intravascular coagulation in Japan. Thromb. Res. 125, 611 (2010).Google Scholar
Kawasugi, K. et al. Prospective evaluation of hemostatic abnormalities in overt DIC due to various underlying diseases. Thromb. Res. 128, 186–90 (2011).CrossRefGoogle ScholarPubMed
Alving, B. M., Spivak, J. L., DeLoughery, T. G. Consultative hematology: Hemostasis and transfusion issues in surgery and critical care medicine. Hematology Am. Soc. Hematol. Educ. Program 320–41, 1998.Google Scholar
Slichter, S. J. Evidence-based platelet transfusion guidelines. Hematol. Am. Soc. Hematol. Educ. Program 172–78 (2007). doi:10.1182/asheducation-2007.1.172Google Scholar
Wada, H. et al. Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines. J. Thromb. Haemost. (2013). doi:10.1111/jth.12155.Google Scholar
Sakuragawa, N., Hasegawa, H., Maki, M., Nakagawa, M. & Nakashima, M. Clinical evaluation of low-molecular-weight heparin (FR-860) on disseminated intravascular coagulation (DIC): A multicenter co-operative double-blind trial in comparison with heparin. Thromb. Res. 72, 475500 (1993).CrossRefGoogle ScholarPubMed
Simpson, E. et al. Recombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia. Cochrane Database Syst. Rev. CD005011 (2012). doi:10.1002/14651858.CD005011.pub4.CrossRefGoogle Scholar
Liu, X.-L. et al. Low-dose heparin as treatment for early disseminated intravascular coagulation during sepsis: A prospective clinical study. Exp. Ther. Med. 7, 604–8 (2014).Google Scholar
Corrigan, J. J. & Jordan, C. M. Heparin therapy in septicemia with disseminated intravascular coagulation: Effect on mortality and on correction of hemostatic defects. N. Engl. J. Med. 283, 778–82 (1970).Google Scholar
Gando, S., Sawamura, A., & Hayakawa, M. Trauma, shock, and disseminated intravascular coagulation: Lessons from the classical literature. Ann. Surg. 254, 1019 (2011).Google Scholar
Vincent, J.-L. et al. A randomized, double-blind, placebo-controlled, phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit. Care Med. 41, 2069–79 (2013).Google Scholar
Jaimes, F. et al. Unfractioned heparin for treatment of sepsis: A randomized clinical trial (the HETRASE study). Crit. Care Med. 37, 1185–96 (2009).CrossRefGoogle ScholarPubMed
Okajima, K. & Uchiba, M. The anti-inflammatory properties of antithrombin III: new therapeutic implications. Semin. Thromb. Hemost. 24, 2732 (1998).Google Scholar
Fourrier, F., Jourdain, M. & Tournoys, A. Clinical trial results with antithrombin III in sepsis. Crit. Care Med. 28, S3843 (2000).Google Scholar
Saito, H. et al. Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: Results of a phase III, randomized, double-blind clinical trial. J. Thromb. Haemost. 5, 3141 (2007).Google Scholar
Yamakawa, K. et al. Treatment effects of recombinant human soluble thrombomodulin in patients with severe sepsis: A historical control study. Crit. Care Lond. Engl. 15, R123 (2011).Google Scholar
Abraham, E. et al. Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N. Engl. J. Med. 353, 1332–41 (2005).CrossRefGoogle Scholar
Abraham, E. et al. Assessment of the safety of recombinant tissue factor pathway inhibitor in patients with severe sepsis: A multicenter, randomized, placebo-controlled, single-blind, dose escalation study. Crit. Care Med. 29, 2081–9 (2001).Google Scholar
CRASH-2 trial collaborators et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomised, placebo-controlled trial. Lancet Lond. Engl. 376, 2332 (2010).Google Scholar
CRASH-2 Collaborators, Intracranial Bleeding Study. Effect of tranexamic acid in traumatic brain injury: A nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study). BMJ 343, d3795 (2011).Google Scholar

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