The incentive structure in science has shifted excessively towards short-term success, potentially hindering creative discoveries in science. But is it possible to fund creative pursuits? Is it possible to create funding structures that might spur on more novelty in medical research? Chapter 12 starts by investigating how we define creativity in science, and what truly constitutes novelty. The chapter then transitions to looking at how current funding structures are designed, and whether these may hinder creativity. The chapter concludes by looking at recent examples of funding structures that might improve the frequency of breakthroughs in medicine as well as allow researchers to pose more potentially exciting questions, resulting in more innovative research.