ABSTRACT

Although affective modification of the startle reflex is a robust phenomenon, it does not occur universally. Research is reviewed suggesting that affective startle modification varies systematically in relation to affective trait dispositions and clinical diagnosis of anxiety, mood, and schizophrenia spectrum disorders. Evidence supports a reliable association between high trait fearfulness and enhanced startle modification by affective valence. Findings for other affective individual differences are thus far only suggestive. Despite the fact that much interest in startle stems from reports of exaggerated startle in posttraumatic stress disorder (PTSD), the precise pattern of startle reactivity and modification in this disorder remains uncertain. Nevertheless, recent studies of affective startle modification in PTSD, as well as in schizophrenia and depression, have yielded provocative results that may ultimately inform our understanding of these disorders. The review emphasizes the need to use a range of affect manipulations and modification paradigms, more powerful research designs, and more appropriate statistical comparisons in future research in this area.