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36 - The role of REM sleep in maintaining neuronal excitability and its possible mechanism of action

from Section V - Functional significance

Published online by Cambridge University Press:  07 September 2011

By
Vibha Madan  and
Birendra N. Mallick
Edited by
Birendra N. Mallick ,
S. R. Pandi-Perumal ,
Robert W. McCarley  and
Adrian R. Morrison
Vibha Madan
Affiliation:
University of Pennsylvania
Birendra N. Mallick
Affiliation:
Jawaharlal Nehru University
Birendra N. Mallick
Affiliation:
Jawaharlal Nehru University
S. R. Pandi-Perumal
Affiliation:
Somnogen Canada Inc, Toronto
Robert W. McCarley
Affiliation:
Harvard University, Massachusetts
Adrian R. Morrison
Affiliation:
University of Pennsylvania
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Summary

Summary

Sleep has been generally divided into rapid eye movement (REM) sleep and non-REM (NREM) sleep in higher order mammals, including humans. Several theories have proposed various functions of different stages of sleep. We hypothesized that REM sleep maintains brain excitability. In this chapter, we discuss the significance of REM sleep in the maintenance of neuronal electrochemical homeostasis, which governs brain excitability. Selective REM-sleep loss increases the activity of Na-K ATPase, a membrane-bound enzyme that maintains neuronal Na+ and K+ homeostasis and, thus, the neuronal resting membrane potential. Further, the REM sleep deprivation-induced increase in Na-K ATPase activity has been attributed to an increased level of norepinephrine in the brain.

Type
Chapter
Information
Rapid Eye Movement Sleep
Regulation and Function
 , pp. 359 - 367
Publisher: Cambridge University Press
Print publication year: 2011

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