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13 - Pontomedullary mediated REM-sleep atonia

from Section III - Neuronal regulation

Published online by Cambridge University Press:  07 September 2011

Yuan-Yang Lai
Affiliation:
VAGLAHS Sepulveda, USA
Jerome M. Siegel
Affiliation:
VAGLAHS Sepulveda, USA
Birendra N. Mallick
Affiliation:
Jawaharlal Nehru University
S. R. Pandi-Perumal
Affiliation:
Somnogen Canada Inc, Toronto
Robert W. McCarley
Affiliation:
Harvard University, Massachusetts
Adrian R. Morrison
Affiliation:
University of Pennsylvania
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Summary

Summary

The medial pontomedullary reticular formation has been implicated in the control of motor activity in REM sleep. Electrical stimulation of points within this area elicits global inhibition of skeletal motor activity in decerebrate animals. This area can be segregated into four distinct subregions based on the response to chemical stimulation. Injection of glutamate, acetylcholine, and corticotropin-releasing factor into the medial pons, the pontine inhibitory area, induces muscle atonia. In the medial medulla, the nucleus magnocellularis (NMC) of the rostroventral medulla responds to glutamate and corticotropin-releasing factor and the nucleus paramedianus of the caudomedial medulla responds to acetylcholine injection, with suppression of muscle tone being induced by these chemicals. In contrast, the transmitter involved in elicitation of atonia by electrical stimulation of the nucleus gigantocellularis of the dorsomedial medulla is unclear. Lesions in this area increase phasic and tonic muscle activity in REM sleep in the chronic animal. Our recent study found that an area rostral to the pons, located at the ventral portion of the junction of the midbrain and pons, the ventral mesopontine junction (VMPJ), is also involved in the control of muscle activity in sleep. Neurotoxic lesions of the VMPJ produce periodic leg movements in slow-wave sleep and increase phasic and tonic muscle activity in REM sleep in the cat, symptoms resembling the human REM sleep behavior disorder (RBD). The anatomical proximity of the VMPJ and the substantia nigra may thus provide a link between RBD and Parkinsonism.

Type
Chapter
Information
Rapid Eye Movement Sleep
Regulation and Function
, pp. 121 - 129
Publisher: Cambridge University Press
Print publication year: 2011

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