The chapter attempts to produce a few guidelines for pressure prediction. These guidelines for best practices are divided into three broad categories: subsurface geological habitat for pore pressure (geology), physics of pore pressure generation (models), and technology for subsurface prediction (tools). An integrated workflow should satisfy four important criteria: (1) the model should be geologically consistent, conforming to the geologic history; (2) model variability should be constrained by bounds derived from physical understanding of the rocks; (3) the model should agree with all available data from wells and seismic measurement; and (4) modeling uncertainty should be rigorously quantified. The chapter describes various approches for uncertainty quantification for pore pressure prediction.