Book contents
- Frontmatter
- Contents
- List of Contributors
- Preface
- Brain mechanisms
- 1 Editor's introduction: From controversy to connectivity
- 2 The functional parcellation of dorsolateral prefrontal cortex and the heterogeneous facets of schizophrenia
- 3 Components of working memory deficit in schizophrenia
- 4 Temporal lobe structural abnormalities in schizophrenia: A selective review and presentation of new magnetic resonance findings
- 5 Location, location, location: The pathway from behavior to brain locus in schizophrenia
- 6 The defects of affect and attention in schizophrenia: A possible neuroanatomical substrate
- Development
- Thinking
- Genetics
- Response and reflections
- Author index
- Subject index
2 - The functional parcellation of dorsolateral prefrontal cortex and the heterogeneous facets of schizophrenia
Published online by Cambridge University Press: 04 May 2010
- Frontmatter
- Contents
- List of Contributors
- Preface
- Brain mechanisms
- 1 Editor's introduction: From controversy to connectivity
- 2 The functional parcellation of dorsolateral prefrontal cortex and the heterogeneous facets of schizophrenia
- 3 Components of working memory deficit in schizophrenia
- 4 Temporal lobe structural abnormalities in schizophrenia: A selective review and presentation of new magnetic resonance findings
- 5 Location, location, location: The pathway from behavior to brain locus in schizophrenia
- 6 The defects of affect and attention in schizophrenia: A possible neuroanatomical substrate
- Development
- Thinking
- Genetics
- Response and reflections
- Author index
- Subject index
Summary
Introduction
Neuropsychological evidence and clinical observations have repeatedly, directly or indirectly, implicated the prefrontal cortex as a site of dysfunction in schizophrenia – based on the similarity of impairments observed in demented patients and those with frontal lobe damage (e.g., Farkas et al., 1984; Levin, 1984a, 1984b; Weinberger et al., 1986; Goldman-Rakic, 1987, 1991). Although such findings have significantly advanced the empirical support for the “frontal-lobe” hypothesis, countless other results in the literature leave considerable room for doubt about any singular explanation for this heterogeneous disorder. Whatever the status of prefrontal involvement in schizophrenia, basic studies of its structure and function have provided support for two major conclusions: Prefrontal cortex is specialized to direct or guide behavior by internalized representations of facts, events and other memoranda (Goldman-Rakic, 1987), and prefrontal cortex carries out its functions through interactions within a complex distributed network of reciprocating pathways (Goldman-Rakic, 1988a, 1988b; Selemon and Goldman-Rakic, 1988; Goldman-Rakic et al., 1993).
It has been argued elsewhere that guiding behavior by representations – ideas and concepts – normally requires working memory and that schizophrenic thought disorder could involve a breakdown in this basic capacity for “on line” processing (Goldman-Rakic, 1987; 1991).
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- PsychopathologyThe Evolving Science of Mental Disorder, pp. 7 - 33Publisher: Cambridge University PressPrint publication year: 1996
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