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Chapter 7 - Medicinal chemistry challenges in the design of next generation antidepressants

Published online by Cambridge University Press:  19 October 2021

By
David P. Rotella
Edited by
Chad E. Beyer  and
Stephen M. Stahl
Chad E. Beyer
Affiliation:
University of Colorado School of Medicine
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

Monoamine-based strategies and targets have provided a useful variety of therapeutic agents with beneficial activity in the treatment of depression. However, this approach has some limitations, including a delayed onset of efficacy and treatment resistance. As a result, there is significant interest in non-monoamine targets and their potential as antidepressants. This search for new treatment modalities has been aided by better understanding of the neurochemical pathways involved in mood. This chapter will review medicinal chemistry advances in a selection of non-monoamine targets of current interest in the field.

Type
Chapter
Information
Next Generation Antidepressants
Moving Beyond Monoamines to Discover Novel Treatment Strategies for Mood Disorders
 , pp. 102 - 118
Publisher: Cambridge University Press
Print publication year: 2010

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