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8 - Role of opiate peptides in regulating energy balance

Published online by Cambridge University Press:  15 September 2009

By
Richard J. Bodnar  and
Allen S. Levine
Edited by
Jenni Harvey  and
Dominic J. Withers
Richard J. Bodnar
Affiliation:
Department of Psychology and Neuropsychology, Doctoral Sub-Program, Queens College, City Univeerdity of New York, USA
Allen S. Levine
Affiliation:
Minnesota Obesity Centeer, Department of Food Science and Nutrition, University of Minnesota, USA
Jenni Harvey
Affiliation:
University of Dundee
Dominic J. Withers
Affiliation:
Imperial College of Science, Technology and Medicine, London
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Summary

The endogenous opioid system, initially characterized over 30 years ago, is a primary example of a multifunctional neural system involved in a wide range of basic homeostatic behaviors, including pain control, sexual behavior, learning and memory, reward, addiction and motivation, immune function, thermoregulatory, cardiovascular and respiratory processes, and as this review indicates, the regulation of energy balance through the modulation of food intake. Given the complexity and breadth of both the endogenous opioid system itself and the complex nature of energy regulation, this review is designed to inform the reader of the systematic steps taken by the field as a whole to understand their interaction. Thus, this review will focus on: (a) discovery and characterization of the endogenous opioids and their receptors, (b) early evidence involving the opioid system in ingestive behavior, (c) the role of opioids in rewarding aspects of food intake, (d) the role of macronutrient choice in opioid-induced feeding, (e) the specific roles of opiate receptor subtypes and specific brain sites in regulating opioid-induced feeding, (f) molecular mechanisms governing opioid-induced feeding, and (g) interactions of opioid-induced feeding with dopamine and other orexigenic neuropeptides.

Discovery and characterization of the endogenous opioids and their receptors

The existence of an endogenous receptor in animals that bound opiates was reported in 1973 (Pert & Snyder, 1973; Simon et al., 1973; Terenius, 1973). Shortly thereafter, it became apparent that multiple subtypes (mu, delta and kappa) of the receptor existed (Martin et al., 1976; Lord et al., 1977).

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Information
Neurobiology of Obesity , pp. 232 - 265
Publisher: Cambridge University Press
Print publication year: 2008

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