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Chapter 12 - Psychopharmacology in Prader-Willi Syndrome

Published online by Cambridge University Press:  26 May 2022

By
Deepan Singh ,
Emily Mozdzer  and
Aaron Pinkhasov
Edited by
Deepan Singh
Deepan Singh
Affiliation:
Maimonides Medical Center in Brooklyn
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Summary

Psychopharmacological interventions for the management of the neuro-behavioral manifestations of PWS that have been described throughout the book are the main focus of this particular chapter. A majority of patients with PWS are on one or more psychiatric medications by the time they reach adulthood. Patients with PWS are uniquely vulnerable to psychiatric illness and require a thorough assessment and diagnosis in order to receive appropriate treatment. This chapter outlines the main classes of medication that have been or, in our opinion, ought to be utilized in patients with PWS. We specifically address their common indications, side effects, and dosage recommendations, among other characteristics. Additionally, the complex phenomenon of drug–drug interactions is discussed in some detail, due to the high incidence of “polypharmacy” in PWS. We recognize that a significant portion of caregiver burden is attributable to neuro-behavioral symptoms and endeavor to provide the information necessary to guide providers in addressing that.

Keywords

psychopharmacologyantipsychoticsantidepressantsmood stabilizersbenzodiazepinespsychotropic medicationsdrug–drug interactionspolypharmacystimulants
Type
Chapter
Information
Neuro-behavioral Manifestations of Prader-Willi Syndrome
A Guide for Clinicians and Caregivers
 , pp. 116 - 144
Publisher: Cambridge University Press
Print publication year: 2022

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