Skip to main content Accessibility help
×
Hostname: page-component-76fb5796d-r6qrq Total loading time: 0 Render date: 2024-04-28T16:45:19.269Z Has data issue: false hasContentIssue false

Chapter 29 - Tobacco Use among Individuals with Cannabis Use

Insights into Co-use and Why It Matters for People with Psychosis

from Part VIII - Special Topics

Published online by Cambridge University Press:  12 May 2023

Deepak Cyril D'Souza
Affiliation:
Staff Psychiatrist, VA Connecticut Healthcare System; Professor of Psychiatry, Yale University School of Medicine
David Castle
Affiliation:
University of Tasmania, Australia
Sir Robin Murray
Affiliation:
Honorary Consultant Psychiatrist, Psychosis Service at the South London and Maudsley NHS Trust; Professor of Psychiatric Research at the Institute of Psychiatry
Get access

Summary

A prominent but under-appreciated concern for individuals with schizophrenia and psychotic disorders using cannabis is the co-use of tobacco. Rates of cannabis and tobacco co-use are on the rise, which may reflect the changing legal landscape surrounding cannabis use. Currently, there are no approved medications for cannabis use disorders and behavioural treatments yield only modest abstinence rates that decline once treatment is discontinued. Converging evidence suggests that treatments for cannabis use disorder may be augmented among co-users if tobacco use is considered and addressed, highlighting the need for a better understanding of cannabis use in the context of tobacco. This chapter reviews the evidence for: (1) mechanisms facilitating the high rates of tobacco use among cannabis users, including those with psychosis; (2) the interactive effects of co-use on the brain, clinical outcomes, and physical health; and (3) the implications for treating cannabis and tobacco co-use in general, and in psychotic disorders in particular. Overall, we present evidence that attests to the public health significance of cannabis and tobacco co-use and the urgent need for the development of empirically informed treatments for these individuals, particularly for those with co-occurring psychosis.

Type
Chapter
Information
Marijuana and Madness , pp. 310 - 320
Publisher: Cambridge University Press
Print publication year: 2023

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Adermark, L. (2011). Modulation of endocannabinoid-mediated long-lasting disinhibition of striatal output by cholinergic interneurons. Neuropharmacology, 61, 13141320.Google Scholar
Agrawal, A., and Lynskey, M. T. (2009). Tobacco and cannabis co-occurrence: Does route of administration matter? Drug Alcohol Depend, 99, 240247.Google Scholar
Agrawal, A., Silberg, J. L., Lynskey, M. T., et al. (2010). Mechanisms underlying the lifetime co-occurrence of tobacco and cannabis use in adolescent and young adult twins. Drug Alcohol Depend, 108, 4955.CrossRefGoogle ScholarPubMed
Akbar, S. A., Tomko, R. L., Salazar, C. A., et al. (2019). Tobacco and cannabis co-use and interrelatedness among adults. Addict Behav, 90, 354361.Google Scholar
Ambrose, B. K., Rostron, B. L., Johnson, S. E., et al. (2014). Perceptions of the relative harm of cigarettes and e-cigarettes among U.S. youth. Am J Prev Med, 47, S53S60.CrossRefGoogle ScholarPubMed
Belanger, R. E., Marclay, F., Berchtold, A., et al. (2013). To what extent does adding tobacco to cannabis expose young users to nicotine? Nicotine Tob Res, 15, 18321838.CrossRefGoogle ScholarPubMed
Berg, C. J., Payne, J., Henriksen, L., et al. (2018). Reasons for marijuana and tobacco co-use among young adults: A mixed methods scale development study. Subst Use Misuse, 53, 357369.Google Scholar
Bonn-Miller, M. O., Zvolensky, M. J., and Johnson, K. A. (2010). Uni-morbid and co-occurring marijuana and tobacco use: Examination of concurrent associations with negative mood states. J Addict Dis, 29, 6877.Google Scholar
Boyle, M. H., and Offord, D. R. (1991). Psychiatric disorder and substance use in adolescence. Can J Psychiatry, 36, 699705.Google Scholar
Brezing, C. A., and Levin, F. R. (2018). The current state of pharmacological treatments for cannabis use disorder and withdrawal. Neuropsychopharmacology, 43, 173194.Google Scholar
Budney, A. J., and Hughes, J. R. (2006). The cannabis withdrawal syndrome. Curr Opin Psychiatry, 19, 233238.CrossRefGoogle ScholarPubMed
Budney, A. J., Moore, B. A., Vandrey, R. G., et al. (2003). The time course and significance of cannabis withdrawal. J Abnorm Psychol, 112, 393402.Google Scholar
Chadi, N., Schroeder, R., Jensen, J. W., et al. (2019). Association between electronic cigarette use and marijuana use among adolescents and young adults: A systematic review and meta-analysis. JAMA Pediatr, 173, e192574.CrossRefGoogle Scholar
Cheer, J. F., Wassum, K. M., Heien, M. L., et al. (2004). Cannabinoids enhance subsecond dopamine release in the nucleus accumbens of awake rats. J Neurosci, 24, 43934400.Google Scholar
Cohen, K., Weizman, A., and Weinstein, A. (2019). Positive and negative effects of cannabis and cannabinoids on health. Clin Pharmacol Ther, 105, 11391147.Google Scholar
Curran, H. V., Freeman, T. P., Mokrysz, C., et al. (2016). Keep off the grass? Cannabis, cognition and addiction. Nat Rev Neurosci, 17, 293306.Google Scholar
D’Souza, D. C., Perry, E., MacDougall, L., et al. (2004). The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: Implications for psychosis. Neuropsychopharmacology, 29, 15581572.CrossRefGoogle ScholarPubMed
Derogatis, L. R. (1993). Brief Symptom Inventory: Administration, Scoring and Procedures Manual. Minneapolis, MN: Systems Inc.Google Scholar
de Dios, M. A., Vaughan, E. L., Stanton, C. A., et al. (2009). Adolescent tobacco use and substance abuse treatment outcomes. J Subst Abuse Treat, 37, 1724.Google Scholar
Filbey, F. M., McQueeny, T., Kadamangudi, S., et al. (2015). Combined effects of marijuana and nicotine on memory performance and hippocampal volume. Behav Brain Res, 293, 4653.Google Scholar
Flatz, A., Belanger, R. E., Berchtold, A., et al. (2013). Assessing tobacco dependence among cannabis users smoking cigarettes. Nicotine Tob Res, 15, 557561.CrossRefGoogle ScholarPubMed
Francis, A. M., Parks, A., Choueiry, J., et al. (2022). Sensory gating in tobacco-naive cannabis users is unaffected by acute nicotine administration. Psychopharmacology, 239, 12791288.Google Scholar
G. B. D. Tobacco Collaborators. (2017). Smoking prevalence and attributable disease burden in 195 countries and territories, 1990–2015: A systematic analysis from the Global Burden of Disease Study 2015. Lancet, 389, 18851906.Google Scholar
Gates, P. J., Sabioni, P., Copeland, J., et al. (2016). Psychosocial interventions for cannabis use disorder. Cochrane Database Syst Rev, 5, CD005336.Google Scholar
Gilbert, D. G., Rabinovich, N. E., and McDaniel, J. T. (2020). Nicotine patch for cannabis withdrawal symptom relief: A randomized controlled trial. Psychopharmacology (Berl), 237, 15071519.CrossRefGoogle ScholarPubMed
Giroud, C., de Cesare, M., Berthet, A., et al. (2015). E-cigarettes: A review of new trends in cannabis use. Int J Environ Res Public Health, 12, 998810008.CrossRefGoogle ScholarPubMed
Goodwin, R. D., Pacek, L. R., Copeland, J., et al. (2018). Trends in daily cannabis use among cigarette smokers: United States, 2002–2014. Am J Public Health, 108, 137142.Google Scholar
Gravely, S., Driezen, P., Smith, D. M., et al. (2020). International differences in patterns of cannabis use among adult cigarette smokers: Findings from the 2018 ITC Four Country Smoking and Vaping Survey. Int J Drug Policy, 79, 102754.CrossRefGoogle ScholarPubMed
Gray, K. M., Sonne, S. C., McClure, E. A., et al. (2017). A randomized placebo-controlled trial of N-acetylcysteine for cannabis use disorder in adults. Drug Alcohol Depend, 177, 249257.Google Scholar
Grenhoff, J., Aston-Jones, G., and Svensson, T. H. (1986). Nicotinic effects on the firing pattern of midbrain dopamine neurons. Acta Physiol Scand, 128, 351358.Google Scholar
Haney, M., Bedi, G., Cooper, Z. D., et al. (2013). Predictors of marijuana relapse in the human laboratory: Robust impact of tobacco cigarette smoking status. Biol Psychiatry, 73, 242248.Google Scholar
Heishman, S. J., Kleykamp, B. A., and Singleton, E. G. (2010). Meta-analysis of the acute effects of nicotine and smoking on human performance. Psychopharmacology (Berl), 210, 453469.CrossRefGoogle ScholarPubMed
Hindocha, C., Brose, L. S., Walsh, H., et al. (2021). Cannabis use and co-use in tobacco smokers and non-smokers: Prevalence and associations with mental health in a cross-sectional, nationally representative sample of adults in Great Britain, 2020. Addiction, 116, 22092219.Google Scholar
Hindocha, C., Freeman, T. P., Ferris, J. A., et al. (2016). No smoke without tobacco: A global overview of cannabis and tobacco routes of administration and their association with intention to quit. Front Psychiatry, 7, 104.Google Scholar
Hindocha, C., Freeman, T. P., Xia, J. X., et al. (2017a). Acute memory and psychotomimetic effects of cannabis and tobacco both ‘joint’ and individually: A placebo-controlled trial. Psychol Med, 47, 27082719.Google Scholar
Hindocha, C., Lawn, W., Freeman, T. P., et al. (2017b). Individual and combined effects of cannabis and tobacco on drug reward processing in non-dependent users. Psychopharmacology (Berl), 234, 31533163.Google Scholar
Hindocha, C., Shaban, N. D., Freeman, T. P., et al. (2015). Associations between cigarette smoking and cannabis dependence: A longitudinal study of young cannabis users in the United Kingdom. Drug Alcohol Depend, 148, 165171.Google Scholar
Jacobsen, L. K., Pugh, K. R., Constable, R. T., et al. (2007). Functional correlates of verbal memory deficits emerging during nicotine withdrawal in abstinent adolescent cannabis users. Biol Psychiatry, 61, 3140.Google Scholar
Kalman, D., Kim, S., Digirolamo, G., et al. (2010). Addressing tobacco use disorder in smokers in early remission from alcohol dependence: The case for integrating smoking cessation services in substance use disorder treatment programs. Clin Psychol Rev, 30, 1224.Google Scholar
Karoly, H. C., Bryan, A. D., Weiland, B. J., et al. (2015). Does incentive-elicited nucleus accumbens activation differ by substance of abuse? An examination with adolescents. Dev Cogn Neurosci, 16, 515.CrossRefGoogle ScholarPubMed
Kelly, B. C. (2005). Bongs and blunts: Notes from a suburban marijuana subculture. J Ethn Subst Abuse, 4, 8197.Google Scholar
Koskinen, J., Lohonen, J., Koponen, H., et al. (2010). Rate of cannabis use disorders in clinical samples of patients with schizophrenia: A meta-analysis. Schizophr Bull, 36, 1115.Google Scholar
Kuhns, L., Kroon, E., Filbey, F., et al. (2020). Unraveling the role of cigarette use in neural cannabis cue reactivity in heavy cannabis users. Addict Biol, 26, e12941.Google Scholar
Lee, D. C., Crosier, B. S., Borodovsky, J. T., et al. (2016). Online survey characterizing vaporizer use among cannabis users. Drug Alcohol Depend, 159, 227233.Google Scholar
Lee, J. P., Battle, R. S., Lipton, R., et al. (2010). ‘Smoking’: Use of cigarettes, cigars and blunts among Southeast Asian American youth and young adults. Health Educ Res, 25, 8396.Google Scholar
de Leon, J., and Diaz, F. J. (2005). A meta-analysis of worldwide studies demonstrates an association between schizophrenia and tobacco smoking behaviors. Schizophr Res, 76, 135157.Google Scholar
Levin, K. H., Copersino, M. L., Heishman, S. J., et al. (2010). Cannabis withdrawal symptoms in non-treatment-seeking adult cannabis smokers. Drug Alcohol Depend, 111, 120127.CrossRefGoogle ScholarPubMed
Livne, O., Shmulewitz, D., Lev-Ran, S., et al. (2019). DSM-5 cannabis withdrawal syndrome: Demographic and clinical correlates in U.S. adults. Drug Alcohol Depend, 195, 170177.Google Scholar
Lorenzetti, V., Chye, Y., Silva, P., et al. (2019). Does regular cannabis use affect neuroanatomy? An updated systematic review and meta-analysis of structural neuroimaging studies. Eur Arch Psychiatry Clin Neurosci, 269, 5971.Google Scholar
Lowe, D. J. E., Coles, A. S., George, T. P., et al. (2019). E-cigarettes. In Danovitch, I., and Mooney, L. J. (eds.) The Assessment and Treatment of Addiction: Best Practices and New Frontiers, 1st ed. (pp. 4356). New York: Elsevier.Google Scholar
Martz, M. E., Trucco, E. M., Cope, L. M., et al. (2016). Association of marijuana use with blunted nucleus accumbens response to reward anticipation. JAMA Psychiatry, 73, 838844.Google Scholar
McClure, E. A., Baker, N. L., and Gray, K. M. (2014). Cigarette smoking during an N-acetylcysteine-assisted cannabis cessation trial in adolescents. Am J Drug Alcohol Abuse, 40, 285291.CrossRefGoogle ScholarPubMed
McClure, E. A., Tomko, R. L., Salazar, C. A., et al. (2019). Tobacco and cannabis co-use: Drug substitution, quit interest, and cessation preferences. Exp Clin Psychopharmacol, 27, 265275.Google Scholar
Mehmedic, Z., Chandra, S., Slade, D., et al. (2010). Potency trends of delta9-THC and other cannabinoids in confiscated cannabis preparations from 1993 to 2008. J Forensic Sci, 55, 12091217.Google Scholar
Mehra, R., Moore, B. A., Crothers, K., et al. (2006). The association between marijuana smoking and lung cancer: A systematic review. Arch Intern Med, 166, 13591367.Google Scholar
Meier, E., and Hatsukami, D. K. (2016). A review of the additive health risk of cannabis and tobacco co-use. Drug Alcohol Depend, 166, 612.Google Scholar
Moore, B. A., and Budney, A. J. (2001). Tobacco smoking in marijuana-dependent outpatients. J Subst Abuse, 13, 583596.Google Scholar
Morean, M. E., Kong, G., Camenga, D. R., et al. (2015). High school students’ use of electronic cigarettes to vaporize cannabis. Pediatrics, 136, 611616.Google Scholar
Moritz, E. D., Zapata, L. B., Lekiachvili, A., et al. (2019). Update: Characteristics of patients in a national outbreak of E-cigarette, or vaping, product use-associated lung injuries – United States, October 2019. MMWR Morb Mortal Wkly Rep, 68, 985989.Google Scholar
Penetar, D. M., Kouri, E. M., Gross, M. M., et al. (2005). Transdermal nicotine alters some of marihuana’s effects in male and female volunteers. Drug Alcohol Depend, 79, 211223.CrossRefGoogle ScholarPubMed
Peng, P., Li, M., Liu, H., et al. (2018). Brain structure alterations in respect to tobacco consumption and nicotine dependence: A comparative voxel-based morphometry study. Front Neuroanat, 12, 43.Google Scholar
Perrine, C. G., Pickens, C. M., Boehmer, T. K., et al. (2019). Characteristics of a multistate outbreak of lung injury associated with E-cigarette use, or vaping – United States, 2019. MMWR Morb Mortal Wkly Rep, 68, 860864.Google Scholar
Peters, E. N., Budney, A. J., and Carroll, K. M. (2012). Clinical correlates of co-occurring cannabis and tobacco use: A systematic review. Addiction, 107, 14041417.Google Scholar
Peters, E. N., Schwartz, R. P., Wang, S., et al. (2014). Psychiatric, psychosocial, and physical health correlates of co-occurring cannabis use disorders and nicotine dependence. Drug Alcohol Depend, 134, 228234.Google Scholar
Ponzoni, L., Moretti, M., Braida, D., et al. (2019). Increased sensitivity to Delta(9)-THC-induced rewarding effects after seven-week exposure to electronic and tobacco cigarettes in mice. Eur Neuropsychopharmacol, 29, 566576.Google Scholar
Qian, W., Huang, P., Shen, Z., et al. (2019). Brain gray matter volume and functional connectivity are associated with smoking cessation outcomes. Front Hum Neurosci, 13, 361.Google Scholar
Quello, S. B., Brady, K. T., and Sonne, S. C. (2005). Mood disorders and substance use disorder: A complex comorbidity. Sci Pract Perspect, 3, 1321.Google Scholar
Rabin, R. A. (2020). Commentary on Walsh et al. (2020): Tobacco and cannabis co-use- considerations for treatment. Addiction, 115, 18151816.Google Scholar
Rabin, R. A., Dermody, S. S., and George, T. P. (2018). Changes in tobacco consumption in cannabis dependent patients with schizophrenia versus non-psychiatric controls during 28-days of cannabis abstinence. Drug Alcohol Depend, 185, 181188.Google Scholar
Rabin, R. A., and George, T. P. (2015). A review of co-morbid tobacco and cannabis use disorders: Possible mechanisms to explain high rates of co-use. Am J Addict, 24, 105116.Google Scholar
Rabin, R. A., Giddens, J. L., and George, T. P. (2014). Relationship between tobacco and cannabis use status in outpatients with schizophrenia. Am J Addict, 23, 170175.Google Scholar
Rabin, R. A., Mackey, S., Parvaz, M. A., et al. (2020). Common and gender-specific associations with cocaine use on gray matter volume: Data from the ENIGMA addiction working group. Hum Brain Mapp, 43, 543554.Google Scholar
Rabin, R. A., Parvaz, M. A., Alia-Klein, N., et al. (2021). Emotion recognition in individuals with cocaine use disorder: The role of abstinence length and the social brain network. Psychopharmacology (Berl), 239, 10191033.Google Scholar
Ramo, D. E., Liu, H., and Prochaska, J. J. (2012). Tobacco and marijuana use among adolescents and young adults: A systematic review of their co-use. Clin Psychol Rev, 32, 105121.Google Scholar
Ramo, D. E., Liu, H., and Prochaska, J. (2013). Validity and reliability of the nicotine and marijuana interaction expectancy (NAMIE) questionnaire. Drug Alcohol Depend, 131, 166170.Google Scholar
Ream, G. L., Benoit, E., Johnson, B. D., et al. (2008). Smoking tobacco along with marijuana increases symptoms of cannabis dependence. Drug Alcohol Depend, 95, 199208.Google Scholar
Rooke, S. E., Norberg, M. M., Copeland, J., et al. (2013). Health outcomes associated with long-term regular cannabis and tobacco smoking. Addict Behav, 38, 22072213.Google Scholar
Rubinstein, M. L., Delucchi, K., Benowitz, N. L., et al. (2018). Adolescent exposure to toxic volatile organic chemicals from E-cigarettes. Pediatrics, 141, e20173557.Google Scholar
Rubinstein, M. L., Rait, M. A., and Prochaska, J. J. (2014). Frequent marijuana use is associated with greater nicotine addiction in adolescent smokers. Drug Alcohol Depend, 141, 159162.Google Scholar
Schauer, G. L., Berg, C. J., Kegler, M. C., et al. (2015). Assessing the overlap between tobacco and marijuana: Trends in patterns of co-use of tobacco and marijuana in adults from 2003–2012. Addict Behav, 49, 2632.Google Scholar
Schauer, G. L., Rosenberry, Z. R., and Peters, E. N. (2017). Marijuana and tobacco co-administration in blunts, spliffs, and mulled cigarettes: A systematic literature review. Addict Behav, 64, 200211.Google Scholar
Schuster, R. M., Crane, N. A., Mermelstein, R., et al. (2015). Tobacco may mask poorer episodic memory among young adult cannabis users. Neuropsychology, 29, 759766.Google Scholar
Schuster, R. M., Mermelstein, R. J., and Hedeker, D. (2016). Ecological momentary assessment of working memory under conditions of simultaneous marijuana and tobacco use. Addiction, 111, 14661476.Google Scholar
Smith, D. M., Miller, C., O’Connor, R. J., et al. (2020a). Modes of delivery in concurrent nicotine and cannabis use (‘co-use’) among youth: Findings from the International Tobacco Control (ITC) Survey. Subst Abus, 42, 19.Google Scholar
Smith, D. M., O’Connor, R, J., Wei, B., et al. (2020b). Nicotine and toxicant exposure among concurrent users (co-users) of tobacco and cannabis. Nicotine Tob Res, 22, 13541363.Google Scholar
Squire, L. R., and Zola-Morgan, S. (1991). The medial temporal lobe memory system. Science, 253, 13801386.CrossRefGoogle ScholarPubMed
Statistics Canada. (2020). Canadian Cannabis Survey 2020: Summary. Ottawa: Statistics Canada.Google Scholar
Stead, L. F., Koilpillai, P., Fanshawe, T. R., et al. (2016). Combined pharmacotherapy and behavioural interventions for smoking cessation. Cochrane Database Syst Rev, 3, CD008286.Google Scholar
Sutherland, M. T., Riedel, M. C., Flannery, J. S., et al. (2016). Chronic cigarette smoking is linked with structural alterations in brain regions showing acute nicotinic drug-induced functional modulations. Behav Brain Funct, 12, 16.Google Scholar
Tan, W. C., Lo, C., Jong, A., et al. (2009). Marijuana and chronic obstructive lung disease: A population-based study. CMAJ, 180, 814820.Google Scholar
Trivers, K. F., Phillips, E., Gentzke, A. S., et al. (2018). Prevalence of cannabis use in electronic cigarettes among US youth. JAMA Pediatr, 172, 10971099.Google Scholar
Tullis, L. M., Dupont, R., Frost-Pineda, K., et al. (2003). Marijuana and tobacco: A major connection? J Addict Dis, 22, 5162.Google Scholar
Van der Kooy, F., Pomahacova, B., and Verpoorte, R. (2009). Cannabis smoke condensate II: Influence of tobacco on tetrahydrocannabinol levels. Inhal Toxicol, 21, 8790.CrossRefGoogle ScholarPubMed
Walsh, H., McNeill, A., Purssell, E., et al. (2020). A systematic review and Bayesian meta-analysis of interventions which target or assess co-use of tobacco and cannabis in single- or multi-substance interventions. Addiction, 115, 18001814.Google Scholar
Wang, J. B., Ramo, D. E., Lisha, N. E., et al. (2016). Medical marijuana legalization and cigarette and marijuana co-use in adolescents and adults. Drug Alcohol Depend, 166, 3238.Google Scholar
Wetherill, R. R., Jagannathan, K., Hager, N., et al. (2015). Cannabis, cigarettes, and their co-occurring use: Disentangling differences in gray matter volume. Int J Neuropsychopharmacol, 18, pyv061.CrossRefGoogle ScholarPubMed
WHO. (2003). Framework Convention on Tobacco Control. Geneva: World Health Organization.Google Scholar
Wignall, N. D., and de Wit, H. (2011). Effects of nicotine on attention and inhibitory control in healthy nonsmokers. Exp Clin Psychopharmacol, 19, 183191.Google Scholar
Zhang, X., Salmeron, B. J., Ross, T. J., et al. (2011). Factors underlying prefrontal and insula structural alterations in smokers. Neuroimage, 54, 4248.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×