Book contents
- Frontmatter
- Contents
- List of contributors
- Foreword
- Preface
- 1 The cannabinoid system: from the point of view of a chemist
- 2 How cannabis works in the brain
- 3 Acute and subacute psychomimetic effects of cannabis in humans
- 4 The association between cannabis use and depression: a review of the evidence
- 5 Cannabis and psychosis proneness
- 6 Is there a specific ‘cannabis psychosis’?
- 7 Cannabis as a potential causal factor in schizophrenia
- 8 Cannabis abuse and the course of schizophrenia
- 9 The endogenous cannabinoid system in schizophrenia
- 10 Cannabinoid ‘model’ psychosis, dopamine–cannabinoid interactions and implications for schizophrenia
- 11 Motives that maintain cannabis use among individuals with psychotic disorders
- 12 Addressing cannabis abuse in people with psychosis
- 13 Residual cognitive effects of long-term cannabis use
- Index
- References
3 - Acute and subacute psychomimetic effects of cannabis in humans
Published online by Cambridge University Press: 07 December 2009
Book contents
- Frontmatter
- Contents
- List of contributors
- Foreword
- Preface
- 1 The cannabinoid system: from the point of view of a chemist
- 2 How cannabis works in the brain
- 3 Acute and subacute psychomimetic effects of cannabis in humans
- 4 The association between cannabis use and depression: a review of the evidence
- 5 Cannabis and psychosis proneness
- 6 Is there a specific ‘cannabis psychosis’?
- 7 Cannabis as a potential causal factor in schizophrenia
- 8 Cannabis abuse and the course of schizophrenia
- 9 The endogenous cannabinoid system in schizophrenia
- 10 Cannabinoid ‘model’ psychosis, dopamine–cannabinoid interactions and implications for schizophrenia
- 11 Motives that maintain cannabis use among individuals with psychotic disorders
- 12 Addressing cannabis abuse in people with psychosis
- 13 Residual cognitive effects of long-term cannabis use
- Index
- References
Summary
Cannabis sativa has been used for centuries for both its medicinal and psychomimetic effects. This chapter outlines the acute and subacute psychomimetic effects of cannabis in humans. Animal experiments with cannabis are not addressed here; the interested reader can find an account of such studies in Chapters 1 and 2 or refer to Adams and Martin (1996) or Chaperon and Thiebot (1999). Similarly, cannabis-associated psychotic disorders in humans are not dealt with here, as these are discussed in Chapters 5–7.
As we shall describe, the response of most people to cannabis is fairly stereotyped. Having said this, the experience of intoxication with any psychomimetic substance is influenced, inter alia, by dose; previous experience (and hence expectation of effect); the personal characteristics of the user (e.g. personality); and the context in which the drug is taken (O'Brien, 1996). Dose is particularly problematic with use of the plant C. sativa, as the proportional content of the major psychoactive compound (Δ9-tetrahydrocannabinol, or THC) varies widely between different strains of the plant, as well as being dependent upon the conditions under which the plant was cultivated. Furthermore, the part of the plant or the type of plant product consumed also affects the amount of THC ingested: for example, cannabis resin has a THC content of up to 10 times that of the traditional cigarette (Ashton, 2001).
- Type
- Chapter
- Information
- Marijuana and MadnessPsychiatry and Neurobiology, pp. 41 - 53Publisher: Cambridge University PressPrint publication year: 2004
References
and (1996). Cannabis: pharmacology and toxicology in animals and humans. Addiction, 91, 1585–1614CrossRefGoogle ScholarPubMed
(1958). A clinical and metabolic study of acute intoxication with Cannabis sativa and its role in the model psychoses. J. Mental Sci., 104, 972–999CrossRefGoogle ScholarPubMed
(2001). Pharmacology and effects of cannabis: a brief review. Br. J. Psychiatry, 178, 101–106CrossRefGoogle ScholarPubMed
Atha, M. J. and Blanchard, S. (1997). Regular Users. Self-Reported Consumption Patterns and Attitudes Towards Drugs Among 1333 Regular Cannabis Users. London, UK: Independent Drug Monitoring Unit
Beardsley, P. M. and Kelly, T. H. (1999). Acute effects of cannabis on human behavior and central nervous system functions. In The Health Effects of Cannabis, ed. H. Kalant, W. Corrigall, W. Hall and R. Smart, pp. 129–169. Toronto: Addiction Research Foundation, Centre for Addiction and Mental Health
, and (1973). Psychiatric assessment of 30 chronic users of cannabis and 30 matched controls. Am. J. Psychiatry, 130, 309–311CrossRefGoogle ScholarPubMed
Berke, J. and Hernton, C. (1974). The Cannabis Experience. London: Quartet Books
and (2002). Involvement of the opioid system in the anxiolytic-like effects induced by delta (9)-tetrahydrocannabinol. Psychopharmacology, 163, 111–117CrossRefGoogle ScholarPubMed
and (1999). Behavioral effects of cannabinoid agents in animals. Crit. Rev. Neurobiol., 13, 243–281CrossRefGoogle ScholarPubMed
, and (2001). Alcohol, cannabis and tobacco use among Australians: a comparison of their associations with other drug use and use disorders, affective and anxiety disorders, and psychosis. Addiction, 96, 1603–1614CrossRefGoogle ScholarPubMed
, , et al. (2002). Cannabinoid–dopamine interactions and psychosis: effects of haloperidol in a cannabinoid ‘model’ psychosis. Schizophrenia Res., 53, 252–253Google Scholar
, , et al. (2002). Cannabis use correlates with schizotypal personality traits in healthy students. Psychiatry Res., 109, 27–35CrossRefGoogle ScholarPubMed
Goode, E. (1970). The Marijuana Smokers. New York: Basic Books
Grinspoon, L. and Bakalar, J. B. (1993). Marihuana, the Forbidden Medicine. New Haven, CT: Yale University Press
, and (1997). Very long-term users of marijuana in the United States: a pilot study. Substance Use Misuse, 32, 249–264CrossRefGoogle ScholarPubMed
and (2001). Cannabinoid modulation of time estimation in the rat. Behavi. Neurosci., 115, 243–246CrossRefGoogle ScholarPubMed
Heishman, S. J. (2002). Effects of marijuana on human performance and assessment of driving impairment. In Biology of Marijuana: From Gene to Behaviour, ed. E. S. Onaivi, pp. 308–332. New York: Taylor and FrancisCrossRef
, , et al. (2001). Blockade of effects of smoked marijuana by the CB1-selective cannabinoid receptor antagonist SR141716. Arch. Gen. Psychiatry, 58, 322–328CrossRefGoogle ScholarPubMed
, , et al. (1967). Effects of delta-9-trans-tetrahydro-cannabinol in man. Psychopharmacologia, 11, 184–188CrossRefGoogle ScholarPubMed
Iversen, L. L. (2000). The Science of Marijuana. Oxford: Oxford University Press
(2001). Psychiatric effects of cannabis. Br. J. Psychiatry, 178, 116–122CrossRefGoogle ScholarPubMed
, , et al. (2003). Modulation of anxiety through blockade of anandamide hydrolysis. Nature Med., 9, 76–81CrossRefGoogle ScholarPubMed
, , et al. (1999). Effect of cannabis use on cognitive functions and driving ability. J. Clin. Psychiatry, 60, 395–399CrossRefGoogle ScholarPubMed
, and (1998). Effects of marijuana on equilibrium, psychomotor performance and simulated driving. Behav. Pharmacol., 9, 599–609CrossRefGoogle ScholarPubMed
and (1999). Human neuroimaging of acute and chronic marijuana use: implications for frontocerebellar dysfunction. Human Psychopharmacol. Clin. Exp., 14, 291–3013.0.CO;2-H>CrossRefGoogle Scholar
Ludlow, F. H. (1857). The Hasheesh Eater: Being Passages from the Life of a Pythagorean. New York: Harper
(1897). The active principle of Indian hemp: a preliminary communication. Lancet, ⅰ, 235–238CrossRefGoogle Scholar
, , and (1998). Cerebellar activity and disturbed time sense after THC. Brain Res., 797, 183–189CrossRefGoogle ScholarPubMed
, , and (1971). Marijuana and the temporal span of awareness. Arch. Gen. Psychiatry, 24, 564–567CrossRefGoogle Scholar
, , and (1976). Operant acquisition of marihuana in man. J. Pharmacol. Exp. Ther., 198, 42–53Google ScholarPubMed
Musty, R. E. (2002). Cannabinoid therapeutic potential in motivational processes, psychological disorders and central nervous system disorders. In Biology of Marijuana: From Gene to Behavior, ed. E. S. Onaivi, pp. 45–74. London: Taylor & FrancisCrossRef
, , et al. (1997). Acute administration of the CB1 cannabinoid receptor antagonist SR141716A induces anxiety-like responses in the rat. Neuroreport, 8, 491–496CrossRefGoogle ScholarPubMed
Nowlis, V. (1965). Research with the mood adjective check list. In Affect, Cognition, and Personality, ed. S. Tomkins and C. Isard, pp. 352–389. New York: Springer
O'Brien, C. P. (1996). Drug addiction and drug abuse. In Goodman and Gilman's The Pharmacological Basis of Therapeutics 9th edn, ed. J. G. Hardman, L. E. Limbird, P. B. Molinoff, R. W. Ruddon and A. G. Gilman, pp. 557–577. New York: McGraw-Hill
, , and (2000). Who is using cannabis as a medicine and why: an exploratory study?J. Psychoact. Drugs, 32, 435–443CrossRefGoogle Scholar
Paton, W. D. M. and Pertwee, R. G. (1973). The actions of cannabis in man. In Marihuana, ed. R. Mechoulam, pp. 287–333. New York: Academic Press
, , and (1990). Drug use and life style among college undergraduates in 1989: a comparison with 1969 and 1978. Am. J. Psychiatry, 147, 998–1001Google ScholarPubMed
, , and (1998). Long-term cannabis use: characteristics of users in an Australian rural area. Addiction, 93, 837–846CrossRefGoogle Scholar
(2001). Therapeutic aspects of cannabis and cannabinoids. Br. J. Psychiatry, 178, 107–115CrossRefGoogle ScholarPubMed
Smiley, A. (1999). Marijuana: on-road and driving simulator studies. In The Health Effects of Cannabis, ed. H. Kalant, W. Corrigal, W. Hall and R. Smart, pp. 173–191. Toronto: Addiction Research Foundation, Centre for Addiction and Mental Health
Solowij, N. (1998). Cannabis and Cognitive Functioning. Cambridge: Cambridge University Press
Solowij, N. (2002). Cannabis and cognitive functioning. In Biology of Marijuana: From Gene to Behaviour, ed. E. S. Onaivi, pp. 308–332. New York: Taylor and Francis
, , and (1997). Anxiety sensitivity and self-reported reasons for drug use. J. Substance Abuse, 9, 223–240CrossRefGoogle ScholarPubMed
and (1972). Psychiatric effects of hashish. Arch. Gen. Psychiatry, 27, 133–136CrossRefGoogle ScholarPubMed
(1996). A community survey of adverse effects of cannabis use. Drug Alcohol Depend., 42, 201–207CrossRefGoogle ScholarPubMed
, , and (1998). Psychiatric symptoms in male cannabis users not using other illicit drugs. Addiction, 93, 487–492CrossRefGoogle Scholar
and (1995). Substance-abuse in patients with comorbid anxiety disorder – a comparative study. Am. J. Addict., 4, 226–233CrossRefGoogle Scholar
, , et al. (1996). Brain glucose-metabolism in chronic marijuana users at baseline and during marijuana intoxication. Psychiatry Res.: Neuroimaging, 67, 29–38CrossRefGoogle ScholarPubMed
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