Book contents
- Manual of Embryo Selection in Human Assisted Reproduction
- Manual of Embryo Selection in Human Assisted Reproduction
- Copyright page
- Contents
- Contributors
- Preface
- Chapter 1 Introduction
- Chapter 2 Embryo Developmental Programming
- Chapter 3 Embryo–Maternal Interactions
- Chapter 4 The Sperm’s Role in Embryo Development
- Chapter 5 The Oocyte’s Role in Embryo Development
- Chapter 6 The Laboratory’s Role in Embryo Development
- Chapter 7 Handling of Gametes and Embryos
- Chapter 8 Noninvasive Morphological Selection of Oocytes
- Chapter 9 Prospects for Bioenergetics for Embryo Selection
- Chapter 10 Static Morphological Assessment for Embryo Selection
- Chapter 11 Dynamic Morphological Assessment for Embryo Selection
- Chapter 12 Noninvasive Analysis of Embryo Nutrient Utilization for Embryo Selection
- Chapter 13 Genomics for Embryo Selection
- Chapter 14 Biopsy Techniques from Polar Body to Blastocyst
- Chapter 15 Cell-Free DNA Analysis for PGT-A
- Chapter 16 What Science May Come for Embryo Selection?
- Epilogue
- Index
- References
Chapter 3 - Embryo–Maternal Interactions
Published online by Cambridge University Press: 26 April 2023
Book contents
- Manual of Embryo Selection in Human Assisted Reproduction
- Manual of Embryo Selection in Human Assisted Reproduction
- Copyright page
- Contents
- Contributors
- Preface
- Chapter 1 Introduction
- Chapter 2 Embryo Developmental Programming
- Chapter 3 Embryo–Maternal Interactions
- Chapter 4 The Sperm’s Role in Embryo Development
- Chapter 5 The Oocyte’s Role in Embryo Development
- Chapter 6 The Laboratory’s Role in Embryo Development
- Chapter 7 Handling of Gametes and Embryos
- Chapter 8 Noninvasive Morphological Selection of Oocytes
- Chapter 9 Prospects for Bioenergetics for Embryo Selection
- Chapter 10 Static Morphological Assessment for Embryo Selection
- Chapter 11 Dynamic Morphological Assessment for Embryo Selection
- Chapter 12 Noninvasive Analysis of Embryo Nutrient Utilization for Embryo Selection
- Chapter 13 Genomics for Embryo Selection
- Chapter 14 Biopsy Techniques from Polar Body to Blastocyst
- Chapter 15 Cell-Free DNA Analysis for PGT-A
- Chapter 16 What Science May Come for Embryo Selection?
- Epilogue
- Index
- References
Summary
Establishment of pregnancy requires successful implantation of a healthy embryo into the woman’s endometrium. Synchrony of development between the embryo and the maternal endometrium is well known as essential in establishment of pregnancy. Ovarian stimulation, that dramatically changes natural hormonal levels, is highly detrimental to development of a ‘receptive endometrium’, which lasts for ~4 days in the mid-secretory phase of a normal cycle. Thus, it is hardly surprising that so few ‘good quality’ embryos implant successfully into the endometrium to establish pregnancy. Until the endometrium is recognised as an equal partner to the embryo and prepared appropriately, we will not see a substantial rise in IVF success. None of the many ‘adjuva nt therapies’ are proven as successful; some do more harm than good. A good test for endometrial receptivity is urgently needed, along with consideration of how clinical protocols can be amended to decrease their harmful effects on the endometrium.
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- Publisher: Cambridge University PressPrint publication year: 2023
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