Skip to main content Accessibility help
×
Hostname: page-component-8448b6f56d-c47g7 Total loading time: 0 Render date: 2024-04-23T18:34:01.705Z Has data issue: false hasContentIssue false

4 - Firm and regional determinants in innovation models: evidence from biotechnology and traditional chemicals

Published online by Cambridge University Press:  22 September 2009

Myriam Mariani
Affiliation:
Istituto di Economia Politica and Centro di Ricerca sui Processi di Innovazione e Internazionalizzazione, Bocconi University, Milan, Italy
Mariana Mazzucato
Affiliation:
The Open University, Milton Keynes
Giovanni Dosi
Affiliation:
Sant'Anna School of Advanced Studies, Pisa
Get access

Summary

Introduction

Firm competencies are discussed in the literature as important sources of firms' competitive advantage. They develop over time and, together with specific routines and communication mechanisms internal to the organization, affect the direction and the outcome of firms' R&D activities (see, for example, Nelson and Winter, 1982, and Dosi et al., 1988).

Recently, however, the economic literature has highlighted the importance of an alternative model for organizing production and innovative activities: the geographical proximity among researchers and institutions in a technological cluster. The contributions on regional clustering and geographically localized knowledge spillovers argue that the cost of transferring knowledge increases with the geographical distance among the parties involved in the exchange. This explains the tendency of innovative activities to locate together (see, for example, Jaffe, 1986; Jaffe, Trajtenberg, and Henderson, 1993; Audretsch and Feldman, 1996; and Swann, Prevezer, and Stout 1998).

So far the literature has analyzed these issues separately. This chapter recombines these two streams of the literature and compares their relative importance in explaining a research output: the value of innovations. It estimates how much of the value of an innovation is affected by the affiliation of the inventors to the same organization, as opposed to spillovers that arise when the inventors are geographically close to each other and to external sources of knowledge. In so doing it expands upon a previous paper by Mariani (2004).

Type
Chapter
Information
Knowledge Accumulation and Industry Evolution
The Case of Pharma-Biotech
, pp. 112 - 144
Publisher: Cambridge University Press
Print publication year: 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Aftalion, F. (1991), A History of the International Chemical Industry, University of Pennsylvania Press, Philadelphia.Google Scholar
Audretsch, D. B., and Feldman, M. P. (1996), “Knowledge spillovers and the geography of innovation and production,” American Economic Review, 86 (3), 630–40.Google Scholar
Breschi, S. (1999), “Spatial patterns of innovation: evidence from patent data,” in Gambardella, A. and Malerba, F. (eds.), The Organisation of Economic Innovation in Europe, Cambridge University Press, Cambridge, 71–102.Google Scholar
Dosi, G., Freeman, C., Nelson, R. R., Silverberg, G., and Soete, L. (1988), Technical Change and Economic Theory, Francis Pinter, London.Google Scholar
Griliches, Z. (1990), “Patent statistics as economic indicators: a survey,” Journal of Economic Literature, 28, 1661–707.Google Scholar
Griliches, Z., A. Pakes, and B. Hall (1987), “The value of patents as indicators of inventive activity,” in Dasgupta, P. and Stoneman, P. (eds.), Economic Policy and Technological Performance, Cambridge University Press, Cambridge, 97–124.CrossRefGoogle Scholar
Hall, B., Jaffe, A., and Trajtenberg, M. (2001), The NBER Patent Citations Data File: Lessons, Insights and Methodological Tools, Working Paper no. 8498, National Bureau of Economic Research, Cambridge, MA.CrossRefGoogle Scholar
Hall, B., Jaffe, A., and Trajtenberg, M.(2005), “Market value and patent citations,” RAND Journal of Economics, 36, 16–38.Google Scholar
Harhoff, D., Scherer, F., and Vopel, K. (2003), “Citations, family size, opposition and the value of patent rights: evidence from Germany,” Research Policy, 32, 1343–63.CrossRefGoogle Scholar
Henderson, R. M., and Cockburn, I. (1996), “Scale, scope and spillovers: the determinants of research productivity in drug discovery,” RAND Journal of Economics, 27 (1), 32–59.CrossRefGoogle ScholarPubMed
Jaffe, A. (1986), “Technological opportunity and spillovers of R&D: evidence from firms' patents profits and market value,” American Economic Review, 76 (8), 984–1001.Google Scholar
Jaffe, A., Trajtenberg, M., and Henderson, R. (1993), “Geographic localization of knowledge spillovers as evidenced by patent citations,” Quarterly Journal of Economics, 63 (3), 577–98.CrossRefGoogle Scholar
Klepper, S. (1996), “Entry, exit, growth, and innovation over the product life cycle,” American Economic Review, 86 (4), 562–83.Google Scholar
Klepper, S., and Sleeper, S. (2002), Entry by Spinoffs, Paper on Economics and Evolution no. 0207, Evolutionary Economics Group, Max Planck Institute of Economics, Jena.Google Scholar
Lanjouw, J. O., and Schankerman, M. (2004), “Patent quality and research productivity: measuring innovation with multiple indicators,” Economic Journal, 114, 441–65.CrossRefGoogle Scholar
Mariani, M. (2004), “What determines technological hits? Geography vs. firm competencies,” Research Policy, 33 (10), 1565–82.CrossRefGoogle Scholar
Nelson, R. R., and Winter, S. G. (1982), An Evolutionary Theory of Economic Change, Harvard University Press, Cambridge, MA.Google Scholar
Orsenigo, L. (1989), The Emergence of Biotechnology: Institutions and Markets in Industrial Innovations, Francis Pinter, London.Google Scholar
Powell, W., Kaput, K., and Smith-Doerr, L. (1996), “Interorganisational collaboration and the locus of innovation: networks of learning in biotechnology,” Administrative Science Quarterly, 41 (1), 116–45.CrossRefGoogle Scholar
Swann, P., Prevezer, M., and Stout, D. (eds.) (1998), The Dynamics of Industrial Clustering: International Comparisons in Computing and Biotechnology, Oxford University Press, Oxford.Google Scholar
Teece, D. J., Pisano, G., and Shuen, A. (1997), “Dynamic capabilities and strategic management,” Strategic Management Journal, 18, 509–34.3.0.CO;2-Z>CrossRefGoogle Scholar
Trajtenberg, M. (1990), “A penny for your quotes: patent citations and the value of innovation,” RAND Journal of Economics, 21 (1), 172–87.CrossRefGoogle Scholar
Verspagen, B. (1999), “European regional clubs: do they exist and where are they heading? On economic and technological differences between European regions,” in Adams, J. and Pigliaru, F. (eds.), Economic Growth and Change: National and Regional Patterns of Convergence and Divergence, Edward Elgar, Cheltenham, 236–56.CrossRefGoogle Scholar
Wlash, V. (1984), “Invention and innovation in the chemical industry: demand-pull or discovery-push?,” Research Policy, 13, 211–34.CrossRefGoogle Scholar
Zucker, L. G., Darby, M. R., and Armstrong, J. (1998), “Geographically localized knowledge: spillovers or markets?,” Economic Inquiry, 36, 65–86.CrossRefGoogle Scholar
Zucker, L. G., Darby, M. R., and Brewer, M. (1998), “Intellectual human capital and the birth of U.S. biotechnology enterprises,” American Economic Review, 88 (1), 290–306.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×