The focus of this chapter is Gregory’s ordering of exegetical, spiritual, administrative, intellectual, emotional, and gendered knowledge across his oeuvre. The sections are organised by genre into three groups according to the kind of knowledge ordered within. Gregory’s homilies and commentaries on scripture were primarily intended to convey exegetical knowledge within a framework that prioritised divine law as the primary ordering principle in the social hierarchy. His Pastoral Rule and the Dialogues both employed knowledge of the human passions to teach spiritual truths and offer practical advice for living a Christian life in emotional communities. Gregory’s many letters inscribed his strictly hierarchical social order, with special attention to networks of women of influence outside Rome. A constant feature across Gregory’s oeuvre was the coupling of spiritual and intellectual knowledge for the benefit of all levels of society and for the sake of the church.