Skip to main content Accessibility help
×
Hostname: page-component-76fb5796d-dfsvx Total loading time: 0 Render date: 2024-04-26T04:45:27.469Z Has data issue: false hasContentIssue false

Chapter 9

Published online by Cambridge University Press:  05 May 2022

R. John Aitken
Affiliation:
University of Newcastle, New South Wales
Get access

Summary

How do we escape the trap?Many of the social, biological and environmental mechanisms that are driving down human fertility, are self-reinforcing. They operate to accelerate the rate of fertility loss, not stabilize it. Escape from this downward spiral will involve several initiatives that, working together, may provide a measure of control over the rate and depth of fertility decline. For example, we need a complete overhaul of sex education that recognizes the fragility of human fertility and is not so focused on the prevention of teenage pregnancies. We also need to raise the profile of reproductive toxicology so that we can secure better control over the release of potentially harmful compounds into the biosphere. There is a particular need to control male exposures to oestrogens and to counteract those elements of lifestyle, metabolism and the environment, responsible for creating oxidative stress in both the male and female reproductive tract. Accommodating the ART industry would be easier if we secured a deeper understanding of the causes of human infertility so that ART does not become the default therapy for every couple and, when it is used, that IVF is preferred over ICSI. Finally, we need to engineer new social structures wherein fertility is facilitated and encouraged.

Type
Chapter
Information
The Infertility Trap
Why life choices impact your fertility and why we must act now
, pp. 305 - 329
Publisher: Cambridge University Press
Print publication year: 2022

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

9.9 References

Aitken, JB, Naumovski, N, Curry, B, et al. Characterization of an L-amino acid oxidase in equine spermatozoa. Biol Reprod 2015;92(5):125.CrossRefGoogle ScholarPubMed
Aitken, RJ. Antioxidant trials-the need to test for stress. Hum Reprod Open 2021;2021(1):hoab007.CrossRefGoogle ScholarPubMed
Aitken, RJ, Baker, MA. The role of genetics and oxidative stress in the etiology of male infertility-a unifying hypothesis? Front Endocrinol (Lausanne) 2020;11:581838.Google Scholar
Aitken, RJ, Bakos, HW. Should we be measuring DNA damage in human spermatozoa? New light on an old question. Hum Reprod 2021;36(5):11751185.Google Scholar
Aitken, RJ, De Iuliis, GN, Nixon, B. The sins of our forefathers: paternal impacts on de novo mutation rate and development. Annu Rev Genet 2020;54:124.CrossRefGoogle ScholarPubMed
Aitken, RJ, Krausz, C. Oxidative stress, DNA damage and the Y chromosome. Reproduction 2001;122(4):497506.CrossRefGoogle ScholarPubMed
Belva, F, Bonduelle, M, Buysse, A, et al. Chromosomal abnormalities after ICSI in relation to semen parameters: results in 1114 fetuses and 1391 neonates from a single center. Hum Reprod 2020;35(9):21492162.CrossRefGoogle ScholarPubMed
Belva, F, Bonduelle, M, Tournaye, H. Endocrine and reproductive profile of boys and young adults conceived after ICSI. Curr Opin Obstet Gynecol 2019;31(3):163169.Google Scholar
Blahak, P. Vitamin E in the treatment of male sterility. Cesk Gynekol 1947;12(3–4):80–5.Google Scholar
Canipari, R, De Santis, L, Cecconi, S. Female Fertility and Environmental Pollution. Int J Environ Res Public Health 2020;17(23):8802.Google Scholar
Cederroth, CR, Auger, J, Zimmermann, C, Eustache, F, Nef, S. Soy, phyto-oestrogens and male reproductive function: a review. Int J Androl 2010;33(2):304316.CrossRefGoogle ScholarPubMed
Domínguez-López, I, Yago-Aragón, M, Salas-Huetos, A, et al. Effects of dietary phytoestrogens on hormones throughout a human lifespan: a review. Nutrients 2020;12(8):2456.CrossRefGoogle ScholarPubMed
Evenson, DP, Djira, G, Kasperson, K, Christianson, J. Relationships between the age of 25,445 men attending infertility clinics and sperm chromatin structure assay (SCSA®) defined sperm DNA and chromatin integrity. Fertil Steril 2020;114(2):311320CrossRefGoogle Scholar
Giulivo, M, Lopez de Alda, M, Capri, E, Barceló, D. Human exposure to endocrine disrupting compounds: their role in reproductive systems, metabolic syndrome and breast cancer: a review. Environ Res 2016;151:251264.CrossRefGoogle ScholarPubMed
Houston, B, Curry, B, Aitken, RJ. Human spermatozoa possess an IL4I1 l-amino acid oxidase with a potential role in sperm function. Reproduction 2015;149(6):587596.CrossRefGoogle ScholarPubMed
Joseph, T, Mascarenhas, M, Karuppusami, R, et al. Antioxidant pretreatment for male partner before ART for male factor subfertility: a randomized controlled trial. Hum Reprod Open 2020;2020(4):hoaa050.CrossRefGoogle ScholarPubMed
Koppers, AJ, De Iuliis, GN, Finnie, JM, McLaughlin, EA, Aitken, RJ. Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa. J Clin Endocrinol Metab 2008;93(8):3199–207.Google Scholar
Landrigan, PJ, Stegeman, JJ, Fleming, LE, et al. Human health and ocean pollution. Ann Glob Health 2020;86(1):151.Google Scholar
Luke, B, Brown, MB, Wantman, E, et al. The risk of birth defects with conception by ART. Hum Reprod 2021;36(1):116129.Google Scholar
Mack, WS. Some aspects of male infertility. Glasgow Med J 1945;143(3):8792.Google Scholar
Morris, RH, Counsell, SJ, McGonnell, IM, Thornton, C. Early life exposure to air pollution impacts neuronal and glial cell function leading to impaired neurodevelopment. Bioessays 2021;43(9):e2000288.CrossRefGoogle ScholarPubMed
Musset, B, Clark, RA, DeCoursey, TE, et al. NOX5 in human spermatozoa: expression, function, and regulation. J Biol Chem 2012;287(12):93769388.Google Scholar
Rich, AL, Phipps, LM, Tiwari, S, Rudraraju, H, Dokpesi, PO. The increasing prevalence in intersex variation from toxicological dysregulation in fetal reproductive tissue differentiation and development by endocrine-disrupting chemicals. Environ Health Insights 2016;10:163171.Google Scholar
Rim, KT. Reproductive toxic chemicals at work and efforts to protect workers’ health: a literature review. Saf Health Work 2017;8(2):143150.CrossRefGoogle ScholarPubMed
Ross, C, Morriss, A, Khairy, M, et al. A systematic review of the effect of oral antioxidants on male infertility. Reprod Biomed Online 2010;20(6):711723.Google Scholar
Showell, MG, Brown, J, Yazdani, A, Stankiewicz, MT, Hart, RJ. Antioxidants for male subfertility. Cochrane Database Syst Rev 2011;1(1):CD007411.Google Scholar
Smits, RM, Mackenzie-Proctor, R, Yazdani, A, et al. Antioxidants for male subfertility. Cochrane Database Syst Rev 2019;3(3):CD007411.Google Scholar
Steiner, AZ, Hansen, KR, Barnhart, KT, et al. The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial. Fertil Steril 2020;113(3):552560.CrossRefGoogle ScholarPubMed
Swan, SH, Colino, S. Count Down: How our Modern World is Threatening Sperm Counts, Altering Male and Female Reproductive Development, and Imperiling the Future of the Human Race. New York, Scribner, 2021.Google Scholar
Vatannejad, A, Tavilani, H, Sadeghi, MR, et al. Evaluation of the NOX5 protein expression and oxidative stress in sperm from asthenozoospermic men compared to normozoospermic men. J Endocrinol Invest 2019;42(10):11811189.CrossRefGoogle ScholarPubMed
Vessey, W, Saifi, S, Sharma, A, et al. Baseline levels of seminal reactive oxygen species predict improvements in sperm function following antioxidant therapy in men with infertility. Clin Endocrinol (Oxf) 2021;94(1):102110.CrossRefGoogle ScholarPubMed
Xavier, MJ, Mitchell, LA, McEwan, KE, Scott, RJ, Aitken, RJ. Genomic integrity in the male germ line: evidence in support of the disposable soma hypothesis. Reproduction 2018;156(3):269282.CrossRefGoogle ScholarPubMed
Zhang, H, Liu, H, Kataoka, S, et al. L-amino acid oxidase 1 in sperm is associated with reproductive performance in male mice and bulls. Biol Reprod 2021;104(5):11541161.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

  • Chapter 9
  • R. John Aitken, University of Newcastle, New South Wales
  • Book: The Infertility Trap
  • Online publication: 05 May 2022
  • Chapter DOI: https://doi.org/10.1017/9781108935593.010
Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

  • Chapter 9
  • R. John Aitken, University of Newcastle, New South Wales
  • Book: The Infertility Trap
  • Online publication: 05 May 2022
  • Chapter DOI: https://doi.org/10.1017/9781108935593.010
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Chapter 9
  • R. John Aitken, University of Newcastle, New South Wales
  • Book: The Infertility Trap
  • Online publication: 05 May 2022
  • Chapter DOI: https://doi.org/10.1017/9781108935593.010
Available formats
×