Evolutionary Biology of Malarial Parasites

doi:10.1017/CBO9780511546259.005

4 - Evolutionary Biology of Malarial Parasites

Published online by Cambridge University Press: 10 August 2009

Ananias A. Escalante and

Altaf A. Lal

Edited by

Krishna R. Dronamraju

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Ananias A. Escalante: Affiliation:
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333
Altaf A. Lal: Affiliation:
U.S. Embassy, New Delhi, 110021, India
Krishna R. Dronamraju: Affiliation:
Foundation for Genetic Research, Houston, Texas

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Summary

INTRODUCTION

Analysis of Plasmodium spp. genome sequences would allow for the discovery of thousands of new genes and proteins, providing a unique opportunity for understanding the complex biology of malarial parasites. However, the identification of these new genes will be followed by the same old questions that researchers have faced for nearly three decades: how variable are the newly identified genes? How is such variation generated and maintained? How can this diversity affect intervention efforts?

Understanding the origin and extent of malarial parasites' genetic diversity, and the implications of these on the development of new intervention strategies, requires a close collaboration between biomedical researchers and evolutionary biologists. In the case of malaria research, as is the case in the study of many other infectious diseases, biomedical researchers/public health professionals and evolutionary biologists have traditionally worked in isolation.

Biomedical researchers and public health managers often seek answers to the following questions: What are the specific clinical end points in malaria? What level of efficacy can be expected from a multivalent vaccine? How does drug-resistance emerge? How quickly do drug-resistant parasites disperse? What is the impact of transmission pressure on the dispersal of drug-resistant parasites? Is it better to use one drug at a time or to use a “cocktail” before any of the drugs become ineffective? What is the impact of bed-nets on the selection of parasite lines?

Type: Chapter
Information: Infectious Disease and Host-Pathogen Evolution , pp. 75 - 112

DOI: https://doi.org/10.1017/CBO9780511546259.005 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2004

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