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Chapter 26 - Risk of Transplanting Malignant Cells in Cryopreserved Ovarian Tissue

from Section 7 - Ovarian Cryopreservation and Transplantation

Published online by Cambridge University Press:  27 March 2021

By
Marie-Madeleine Dolmans  and
Rossella Masciangelo
Edited by
Jacques Donnez  and
S. Samuel Kim
Jacques Donnez
Affiliation:
Catholic University of Louvain, Brussels
S. Samuel Kim
Affiliation:
University of Kansas School of Medicine
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Summary

Successful live births after transplantation of frozen-thawed human ovarian tissue have been observed since the first report in 2004 [1]. Up to 2017, approximately 130 live births have been achieved [2]. Currently, this procedure is performed for children, adolescents, and young adults with cancer in many countries.

The standard method of ovarian tissue cryopreservation is slow freezing, but rapid freezing (also called “vitrification”) has increasingly been reported as an alternate cryopreservation method in recent years. The present article reviews recent findings with regard to techniques for vitrification of ovarian tissue.

Type
Chapter
Information
Fertility Preservation
Principles and Practice
 , pp. 302 - 312
Publisher: Cambridge University Press
Print publication year: 2021

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