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20 - The Medical Management of Epilepsy

Basic Principles

from Section 5 - The Medical Management of Epilepsy

Published online by Cambridge University Press:  13 April 2017

By
Torbjörn Tomson
Edited by
Ennapadam S. Krishnamoorthy ,
Simon D. Shorvon  and
Steven C. Schachter
Ennapadam S. Krishnamoorthy
Affiliation:
Institute of Neurological Sciences, Chennai
Simon D. Shorvon
Affiliation:
University College London
Steven C. Schachter
Affiliation:
Harvard Medical School, Massachusetts
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Type
Chapter
Information
Epilepsy
A Global Approach
 , pp. 87 - 91
Publisher: Cambridge University Press
Print publication year: 2017

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References

Perucca, E, Beghi, E, Dulac, O, Shorvon, S, Tomson, T. Assessing risk to benefit ratio in antiepileptic drug therapy. Epilepsy Res 2000; 41:107–39.CrossRefGoogle ScholarPubMed
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Hauser, W A, Rich, S S, Lee, J R, Annegers, J F, Anderson, V E. Risk of recurrent seizures after two unprovoked seizures. N Engl J Med 1998; 338:429–34.CrossRefGoogle ScholarPubMed
First Seizure Trial Group (FIRST Group). Randomized clinical trial on the efficacy of antiepileptic drugs in reducing the risk of relapse after a first unprovoked tonic clonic seizure. Neurology 1993; 43:478–83.Google Scholar
Marson, A, Jacoby, A, Johnson, A, et al. Immediate versus deferred antiepileptic drug treatment for early epilepsy and single seizures: a randomised controlled trial. Lancet 2005; 365:2007–13.CrossRefGoogle ScholarPubMed
Kim, L G, Johnston, T L, Marson, A G, Chadwick, D W; MRC MESS Study group. Prediction of risk of recurrence after a single seizure and early epilepsy: further results from the MESS trial. Lancet Neurol 2006; 5:317–22.CrossRefGoogle ScholarPubMed
Perucca, E, Dulac, O, Shorvon, S, Tomson, T. Harnessing the clinical potential of antiepileptic drug therapy: dosage optimisation. CNS Drugs 2001; 15:609–21.Google Scholar
Patsalos, P N, Berry, D J, Bourgeois, B F, et al. Antiepileptic drugs – best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies. Epilepsia 2008; 49:1239–76.CrossRefGoogle ScholarPubMed
Specchio, L M, Beghi, E. Should antiepileptic drugs be withdrawn in seizure-free patients? CNS Drugs 2004; 18:201–12.Google Scholar
Chadwick, D, Taylor, J, Johnson, T. Outcomes after seizure recurrence in people with well-controlled epilepsy and the factors that influence it. The MRC Antiepileptic Drug Withdrawal Group. Epilepsia 1996; 37:1043–50.Google Scholar
Schmidt, D, Löscher, W. Uncontrolled epilepsy following discontinuation of antiepileptic drugs in seizure-free patients: a review of current clinical experience. Acta Neurol Scand 2005; 111:291–300.CrossRefGoogle ScholarPubMed

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