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Chapter 3 - Transfusion in Trauma

Published online by Cambridge University Press:  23 August 2019

By
Brit Long
Edited by
Alex Koyfman  and
Brit Long
Alex Koyfman
Affiliation:
University of Texas Southwestern Medical Center
Brit Long
Affiliation:
San Antonio Military Medical Center
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Summary

Hemorrhage is a leading cause of death in trauma, following head injury. Shock is defined by inadequate tissue perfusion with hemodynamic instability and organ dysfunction.1–10 In trauma, the most common cause of shock is due to acute hemorrhage. Advanced Trauma Life Support (ATLS) describes four classes of hemorrhage,1 but these are not relevant to real world practice, due to different injury types (blunt vs. penetrating), age (due to blunted physiologic responses in the elderly), comorbidities, and medication use (beta blockade reduces the chance of tachycardia in response to decreased blood pressure).6–14 Bradycardia may also be seen in hemorrhage, due to several causes including vagal stimulation and failure to mount a tachycardic response.13,14

Type
Chapter
Information
The Emergency Medicine Trauma Handbook , pp. 42 - 55
Publisher: Cambridge University Press
Print publication year: 2019

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References

ATLS Subcommittee; American College of Surgeons’ Committee on Trauma; International ATLS working group. Advanced trauma life support (ATLS®): the ninth edition. J Trauma Acute Care Surg. 2013;74(5):1363–66.Google Scholar
Ball, CG. Damage control resuscitation: history, theory and technique. Can J Surg. 2014;57(1):55–60.CrossRefGoogle ScholarPubMed
Weingart, S, Meyers, CM. Thoughts on the resuscitation of the critically ill trauma patient. EmedHome.com. Available March, 2008.Google Scholar
Dutton, RP. Damage control anesthesia. Int TraumaCare. 2005;(Fall):197–201.Google Scholar
Duchesne, JC, McSwain, NE Jr, Cotton, BA, et al. Damage control resuscitation: the new face of damage control. J Trauma-Inj Infect Crit Care. 2010;69(4):976–90.Google Scholar
Kaafarani, HM, Velmahos, GC. Damage control resuscitation in trauma. Scand J Surg. 2014;103(2):81–88.Google Scholar
Giannoudi, M, Harwood, P. Damage control resuscitation: lessons learned. Eur J Trauma Emerg Surg. 2016 ;42:273–82.CrossRefGoogle ScholarPubMed
Janson, JO, Thomas, R, Loudan, MA, et al. Damage control resuscitation for patients with major trauma. BMJ. 2009;338:1436–40.Google Scholar
Cohen, MJ, Kutcher, M, Redick, B, et al. Clinical and mechanistic drivers of acute traumatic coagulopathy. J Trauma Acute Care Surg. 2013;75(1 Suppl 1):S40–47.Google Scholar
Fox, CJ, Bowman, JN. Advances in resuscitation in the setting of vascular injury. Perspect Vasc Surg Endovasc Ther. 2011;23(2):112–16.CrossRefGoogle ScholarPubMed
Deakin, CD, Low, JL. Accuracy of the advanced trauma life support guidelines for predicting systolic blood pressure using carotid, femoral, and radial pulses: observational study. BMJ. 2000;321(7262):673–74.Google Scholar
Guly, HR, Bouamra, O, Little, R, et al. Testing the validity of the ATLS classification of hypovolaemic shock. Resuscitation. 2010;81(9):1142–47.Google Scholar
Thompson, D, Adams, SL, Barrett, J. Relative bradycardia in patients with isolated penetrating abdominal trauma and isolated extremity trauma. Ann Emerg Med. 1990;19(3):268–75.Google Scholar
Thomas, I, Dixon, J. Bradycardia in acute haemorrhage. BMJ. 2004;328(7437):451–53.Google Scholar
Long, B, Koyfman, A. Red blood cell transfusion in the emergency department. J Emerg Med. 2016;51(2):120–30.Google Scholar
Hebert, PC, Wells, G, Blajchman, MA, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion requirements in critical care investigators, Canadian Critical Care Trials Group. N Engl J Med. 1999;340:409–17.CrossRefGoogle ScholarPubMed
Squires, JE. Risks of transfusion. South Med J. 2011;104(11):762–69.CrossRefGoogle ScholarPubMed
Sandler, SG. Transfusion reactions. Medscape. Available at: http://emedicine.medscape.com/article/206885-overview. Published July, 2016. Accessed July, 2017.Google Scholar
Davenport, R. Pathogenesis of acute traumatic coagulopathy. Transfusion. 2013;53(Suppl 1):23S–27S.CrossRefGoogle ScholarPubMed
Bickel, WH, Wall, MJ Jr, Pepe, PE, et al. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med. 1994;331:1105–9.Google Scholar
Turner, J, Nicholl, J, Webber, L, et al. A randomized controlled trial of prehospital intravenous fluid replacement therapy in serious trauma. Health Technol Assess. 2000;4:1–57.Google Scholar
Dutton, RP, Mackenzie, CF, Scalea, TM. Hypotensive resuscitation during active haemorrhage: impact on in-hospital mortality. J Trauma. 2002;52:1141–46.Google Scholar
Holcomb, JB, Tilley, BC, Baraniuk, S, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA. 2015;313(5):471–82.Google Scholar
Holcomb, JB, Jenkins, D, Rhee, P, et al. Damage control resuscitation: directly addressing the early coagulopathy of trauma. J Trauma. 2007;62(2):307–10.Google ScholarPubMed
Holcomb, JB, Pati, S. Optimal trauma resuscitation with plasma as the primary resuscitative fluid: the surgeon’s perspective. Hematology Am Soc Hematol Educ Program. 2013;2013:656–59.Google Scholar
Holcomb, JB, del Junco, DJ, Fox, EE, et al. PROMMTT Study Group. The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks. JAMA Surg. 2013;148(2):127–36.Google Scholar
del Junco, DJ, Holcomb, JB, Fox, EE, et al. PROMMTT study group. Resuscitate early with plasma and platelets or balance blood products gradually: findings from the PROMMTT study. J Trauma Acute Care Surg. 2013;75(1 suppl 1):S24–30.CrossRefGoogle ScholarPubMed
McLaughlin, DF, Niles, SE, Salinas, J, et al. A predictive model for massive transfusion in combat casualty patients. J Trauma. 2008;64(2 Suppl):S57–63; discussion S63.Google Scholar
Nunez, TC, Voskresensky, IV, Dossett, LA, et al. Early prediction of massive transfusion in trauma: simple as ABC (assessment of blood consumption)? J Trauma. 2009;66(2):346–52.Google Scholar
Cotton, BA, Dossett, LA, Haut, ER, et al. Multicenter validation of a simplified score to predict massive transfusion in trauma. J Trauma. 2010;69(Suppl 1):S33–39.Google Scholar
Weingart, S. Podcast 197 – The logistics of the administration of massive transfusion. Available at: https://emcrit.org/emcrit/logistics-administration-massive-transfusion/ Published April, 2017. Accessed July, 2017.Google Scholar
Cryoprecipitate. Medscape. Available at: http://reference.medscape.com/drug/cryo-cryoprecipitate-999498. Accessed July, 2017.Google Scholar
Cap, AP, Baer, DG, Orman, JA, et al. Tranexamic acid for trauma patients: a critical review of the literature. J Trauma. 2011;71(1 Suppl):S9–14.Google Scholar
Crash-2 trial collaborators. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010;376(9734):23–32.Google Scholar
CRASH-2 collaborators, Roberts, I, Shakur, H, Afolabi, A, et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet. 2011;377(9771):1096–101, 1101.e1–2.Google Scholar
Morrison, JJ, Dubose, JJ, Rasmussen, TE, Midwinter, MJ. Military application of tranexamic acid in trauma emergency resuscitation (MATTERs) study. Arch Surg. 2012;147(2):113–19.CrossRefGoogle ScholarPubMed
Lier, H, Krep, H, Schroeder, S, Stuber, F. Preconditions of hemostasis in trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma. J Trauma. 2008;65:951.Google Scholar
Howland, WS, Schweizer, O, Carlon, GC, Goldiner, PL. The cardiovascular effects of low levels of ionized calcium during massive transfusion. Surg Gynecol Obstet. 1977;145:581.Google ScholarPubMed
Matsushima, K, Benjamin, E, Demetriades, D. Prothrombin complex concentrate in trauma patients. Am J Surg. 2015;209(2):413–17.Google Scholar
Harter, K, Levine, M, Henderson, S. Anticoagulation drug therapy: a review. West J Emerg Med. 2015;16(1):11–17.CrossRefGoogle ScholarPubMed
Ranucci, M, Isgro, G, Soro, G, et al. Efficacy and safety of recombinant activated factor vii in major surgical procedures: systematic review and meta-analysis of randomized clinical trials. Arch Surg. 2008;143(3):296–304.Google Scholar
Semon, G, Cheatham, M. Thromboelastography in trauma. Surgical Critical Care Evidence-Based Guidelines Committee. 2014. Available at: www.surgicalcriticalcare.net/Guidelines/TEG%202014.pdf. Accessed December 12, 2017.Google Scholar
Cotton, B, Faz, G, Hatch, Q, et al. Rapid thromboelastography delivers real-time results that predict transfusion within 1 hour of admission. J Trauma. 2011;71:407–17.Google Scholar
Teodoro da Luz, L, Nascimento, B, Rizoli, S. Thromboelastography (TEG): practical considerations on its clinical use in trauma resuscitation. Scand J Trauma Resusc Emerg Med. 2013;21:29.Google Scholar
Bollinger, D, Seeberg, M, Tanaka, K. Principles and practice of thromboelastography in clinical coagulation management and transfusion practice. Transfus Med Rev. 2012:26(1):1–13.CrossRefGoogle Scholar
Thakur, M, Ahmed, A. A review of thromboelastography. Int J Periop Ultrasound Apply Technol. 2012;1(1):25–29.Google Scholar
da Luz, LT, Nascimento, B, Rizoli, S. Thrombelastography (TEG®): practical considerations on its clinical use in trauma resuscitation. Scand J Trauma, Resusc Emerg Med. 2013;21:29.Google Scholar
Hickey, M, Gatien, M, Taljaard, M, et al. Outcomes of urgent warfarin reversal with frozen plasma versus prothrombin complex concentrate in the emergency department. Circulation. 2013;128(4):360–64.Google Scholar
Mattu, A, Smith, S, Lugassy, D. Clinical toxicology. Emerg Med Clin. 2014;32(1):1–276.Google Scholar
Guyatt, G, Akl, E, Crowther, M, Gutterman, D, Schunemann, H. Antithrombotic therapy and prevention of thrombosis 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2012;141(2):7S–47S.Google Scholar
Awad, N, Cocchio, C. Activated prothrombin complex concentrates for reversal of anticoagulant-associated coagulopathy. P T. 2013;38(11):696–98, 701.Google ScholarPubMed
Fawole, A, Crowther, M, Daw, H. Practical management of bleeding due to the anticoagulants dabigatran, rivaroxaban, and apixaban. CCJM. 2013;80(7):443–51.Google Scholar
Pineda, AA, Taswell, HF. Transfusion reactions associated with anti-IgA antibodies: report of four cases and review of the literature. Transfusion. 1975;15(1):10–15.Google Scholar
Finlay, HE, Cassorla, L, Feiner, J, Toy, P. Designing and testing a computer-based screening system for transfusion-related acute lung injury. Am J Clin Pathol. 2005;124(4):601.CrossRefGoogle ScholarPubMed
Toy, P, Gajic, O, Bacchetti, P, et al. TRALI study group blood. Transfusion-related acute lung injury: incidence and risk factors. Blood. 2012;119(7):1757.Google Scholar
Tinmouth, A, Fergusson, D, Yee, IC, Hebert, PC: Clinical consequences of red cell storage in the critically ill. Transfusion. 2006;46:2014–27.CrossRefGoogle ScholarPubMed
Pidcoke, HF, McFaul, SJ, Ramasubramanian, AK, et al. Primary hemostatic capacity of whole blood: a comprehensive analysis of pathogen reduction and refrigeration effects over time. Transfusion. 2013;53(Suppl 1):137S–149S.Google Scholar
Fisher, AD, Miles, EA, Cap, AP, Strandenes, G, Kane, SF. Tactical damage control resuscitation. Mil Med. 2015;180(8):869–75.CrossRefGoogle ScholarPubMed
Spinella, PC, Perkins, JG, Grathwohl, JG, et al. Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries. J Trauma. 2009;66:S69–76.Google Scholar
Butler, FK, Holcomb, JB, Schreiber, MA, et al. Fluid resuscitation for hemorrhagic shock in tactical combat casualty care: TCCC guidelines change 14-01--2 June 2014. J Spec Oper Med. 2014;14(3):13–38.Google ScholarPubMed
Spinella, PC, Cap, AP. Whole blood: back to the future. Curr Opin Hematol. 2016;23(6):536–42.CrossRefGoogle ScholarPubMed
Strandenes, G, Berséus, O, Cap, AP, et al. Low titer group O whole blood in emergency situations. Shock. 2014;41(Suppl 1):70–75.Google Scholar

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