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Chapter 37 - Childhood Ovarian Cancers

from Section 9 - Ovary and Fallopian Tubes

Published online by Cambridge University Press:  24 November 2021

By
József Zsiros ,
Jacqueline Tromp  and
Frederic Amant
Edited by
Tahir Mahmood ,
Charles Savona-Ventura ,
Ioannis Messinis  and
Sambit Mukhopadhyay
Tahir Mahmood
Affiliation:
Victoria Hospital, Kirkcaldy
Charles Savona-Ventura
Affiliation:
University of Malta, Malta
Ioannis Messinis
Affiliation:
University of Thessaly, Greece
Sambit Mukhopadhyay
Affiliation:
Norfolk & Norwich University Hospital, UK
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Summary

Due to their largely different histology, biology and clinical features, ovarian malignancies in children and adolescents may represent unique problems for clinicians who diagnose and treat mainly adult patients with ovarian neoplasms. In order to provide the highest chance of cure with the lowest risk of late sequelae for these patients, specific knowledge and experience is required for the recognition, diagnosis and optimal management of these tumours.

Keywords

cancerovarychildhoodmalignanttumours
Type
Chapter
Information
The EBCOG Postgraduate Textbook of Obstetrics & Gynaecology
Gynaecology
 , pp. 317 - 329
Publisher: Cambridge University Press
Print publication year: 2021

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References

Brookfield, KF, Cheung, MC, Koniaris, LG, Sola, JE, Fischer, AC. A population-based analysis of 1037 malignant ovarian tumors in the pediatric population. J Surg Res 2009. doi:10.1016/j.jss.2009.03.069.Google Scholar
Schultz, KAP, Harris, AK, Finch, M, et al. DICER1-related Sertoli–Leydig cell tumor and gynandroblastoma: clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry. Gynecol Oncol 2017. doi:10.1016/j.ygyno.2017.09.034.CrossRefGoogle Scholar
Schultz, KAP, Harris, A, Messinger, Y, et al. Ovarian tumors related to intronic mutations in DICER1: a report from the international ovarian and testicular stromal tumor registry. Fam Cancer 2016. doi:10.1007/s10689-015-9831-y.Google Scholar
Lang, JD, Hendricks, WPD. Identification of driver mutations in rare cancers: the role of SMARCA4 in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). Methods Mol Biol 2018. doi:10.1007/978-1-4939-7471-9_20.CrossRefGoogle Scholar
Marro, A, Allen, LM, Kives, SL, Moineddin, R, Chavhan, GB. Simulated impact of pelvic MRI in treatment planning for pediatric adnexal masses. Pediatr Radiol 2016. doi:10.1007/s00247-016-3606-y.Google Scholar
Epelman, M, Chikwava, KR, Chauvin, N, Servaes, S. Imaging of pediatric ovarian neoplasms. Pediatr Radiol 2011. doi:10.1007/s00247-011-2128-x.CrossRefGoogle Scholar
Capito, C, Arnaud, A, Hameury, F, et al. Dysgerminoma and gonadal dysgenesis: the need for a new diagnosis tree for suspected ovarian tumours. J Pediatr Urol 2011. doi:10.1016/j.jpurol.2011.02.021.CrossRefGoogle Scholar
Renaud, EJ, Sømme, S, Islam, S, et al. Ovarian masses in the child and adolescent: an American Pediatric Surgical Association Outcomes and Evidence-Based Practice Committee systematic review. J Pediatr Surg 2019. doi:10.1016/j.jpedsurg.2018.08.058.Google Scholar
Tamauchi, S, Kajiyama, H, Yoshihara, M, et al. Reproductive outcomes of 105 malignant ovarian germ cell tumor survivors: a multicenter study. Am J Obstet Gynecol 2018. doi:10.1016/j.ajog.2018.07.021.CrossRefGoogle Scholar
Rogers, PC, Olson, TA, Cullen, JW, et al. Treatment of children and adolescents with stage II testicular and stages I and II ovarian malignant germ cell tumors: a Pediatric Intergroup study – Pediatric Oncology Group 9048 and Children’s Cancer Group 8891. J Clin Oncol 2004;22:3563–3569.CrossRefGoogle ScholarPubMed
Madenci, AL, Vandewalle, RJ, Dieffenbach, BV, et al. Multicenter pre-operative assessment of pediatric ovarian malignancy. J Pediatr Surg 2019. doi:10.1016/j.jpedsurg.2019.02.019.CrossRefGoogle Scholar
Madenci, AL, Levine, BS, Laufer, MR, et al. Preoperative risk stratification of children with ovarian tumors. J Pediatr Surg 2016. doi:10.1016/j.jpedsurg.2016.05.004.Google Scholar
Abbas, PI, Dietrich, JE, Francis, JA, et al. Ovarian-sparing surgery in pediatric benign ovarian tumors. J Pediatr Adolesc Gynecol 2016. doi:10.1016/j.jpag.2016.03.009.Google Scholar
Faure-Conter, C, Pashankar, F. Immature ovarian teratoma: when to give adjuvant therapy? J Pediatr Hematol Oncol 2017. doi:10.1097/MPH.0000000000000950.Google Scholar
Pashankar, F, Hale, JP, Dang, H, et al. Is adjuvant chemotherapy indicated in ovarian immature teratomas? A combined data analysis from the Malignant Germ Cell Tumor International Collaborative. Cancer 2016. doi:10.1002/cncr.29732.CrossRefGoogle Scholar
Terenziani, M, Cecchetto, G, Inserra, A, et al. Mature and immature teratoma: results of the second pediatric AIEOP (Associazione Italiana Di Ematologia Oncologia Pediatrica) Italian study. Pediatr Blood Cancer 2014;61:S120. doi:10.1002/pbc.25314.Google Scholar
Satoh, T, Aoki, Y, Kasamatsu, T, et al. Administration of standard-dose BEP regimen (bleomycin + etoposide + cisplatin) is essential for treatment of ovarian yolk sac tumour. Eur J Cancer 2015. doi:10.1016/j.ejca.2014.12.004.CrossRefGoogle Scholar
Shaikh, F, Cullen, JW, Olson, TA, et al. Reduced and compressed cisplatin-based chemotherapy in children and adolescents with intermediate-risk extracranial malignant germ cell tumors: a report from the Children’s Oncology Group. J Clin Oncol 2017. doi:10.1200/JCO.2016.67.6544.CrossRefGoogle Scholar
Frazier, AL, Stoneham, S, Rodriguez-Galindo, C, et al. Comparison of carboplatin versus cisplatin in the treatment of paediatric extracranial malignant germ cell tumours: a report of the Malignant Germ Cell International Consortium. Eur J Cancer 2018;98:30–37.CrossRefGoogle ScholarPubMed
Shah, R, Xia, C, Krailo, M, et al. Is carboplatin-based chemotherapy as effective as cisplatin-based chemotherapy in the treatment of advanced-stage dysgerminoma in children, adolescents and young adults? Gynecol Oncol 2018. doi:10.1016/j.ygyno.2018.05.025.Google Scholar
Frazier, AL, Hale, JP, Rodriguez-Galindo, C, et al. Revised risk classification for pediatric extracranial germ cell tumors based on 25 years of clinical trial data from the United Kingdom and United States. J Clin Oncol 2015. doi:10.1200/JCO.2014.58.3369.Google Scholar
Fresneau, B, Orbach, D, Faure-Conter, C, et al. Sex-cord stromal tumors in children and teenagers: results of the TGM-95 Study. Pediatr Blood Cancer 2015. doi:10.1002/pbc.25614.Google Scholar
Schneider, DT, Calaminus, G, Wessalowksi, R, et al. Ovarian sex cord–stromal tumors in children and adolescents. J Clin Oncol 2003;21:2357–2363. doi:10.1200/JCO.2003.05.038.CrossRefGoogle ScholarPubMed
Schneider, DT, Orbach, D, Cecchetto, G, et al. Ovarian Sertoli Leydig cell tumours in children and adolescents: an analysis of the European Cooperative Study Group on Pediatric Rare Tumors (EXPeRT). Eur J Cancer 2015;51:543–550.CrossRefGoogle Scholar
Cecchetto, G, Ferrari, A, Bernini, G, et al. Sex cord stromal tumors of the ovary in children: a clinicopathological report from the Italian TREP project. Pediatr Blood Cancer 2011. doi:10.1002/pbc.22918.CrossRefGoogle Scholar
Calaminus, G, Wessalowski, R, Harms, D, Göbel, U. Juvenile granulosa cell tumors of the ovary in children and adolescents: results from 33 patients registered in a prospective cooperative study. Gynecol Oncol 1997. doi:10.1006/gyno.1997.4695.Google Scholar
Powell, JL, Kotwall, CA, Shiro, BC. Fertility-sparing surgery for advanced juvenile granulosa cell tumor of the ovary. J Pediatr Adolesc Gynecol 2014. doi:10.1016/j.jpag.2013.10.001.CrossRefGoogle Scholar
Distelmaier, F, Calaminus, G, Harms, D, et al. Ovarian small cell carcinoma of the hypercalcemic type in children and adolescents: a prognostically unfavorable but curable disease. Cancer 2006;107:2298–2306.CrossRefGoogle ScholarPubMed
Pressey, JG, Kelly, DR, Hawthorne, HT. Successful treatment of preadolescents with small cell carcinoma of the ovary hypercalcemic type. J Pediatr Hematol Oncol 2013. doi:10.1097/MPH.0b013e318282cca8.CrossRefGoogle Scholar
Ripperger, T, Bielack, SS, Borkhardt, A, et al. Childhood cancer predisposition syndromes: a concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology. Am J Med Genet Part A 2017. doi:10.1002/ajmg.a.38142.CrossRefGoogle Scholar
Kurobe, M, Kawai, K, Oikawa, T, et al. Paclitaxel, ifosfamide, and cisplatin (TIP) as salvage and consolidation chemotherapy for advanced germ cell tumor. J Cancer Res Clin Oncol 2015. doi:10.1007/s00432-014-1760-x.CrossRefGoogle Scholar
Einhorn, LH. Salvage chemotherapy for patients with germ cell tumors: is there a best regimen? J Clin Oncol 2012. doi:10.1200/jco.2011.40.4160.Google Scholar
Rashdan, S, Einhorn, LH. Salvage therapy for patients with germ cell tumor. J Oncol Pract 2016. doi:10.1200/jop.2016.011411.CrossRefGoogle Scholar
Faure-Conter, C, Orbach, D, Cropet, C, et al. Salvage therapy for refractory or recurrent pediatric germ cell tumors: the French SFCE experience. Pediatr Blood Cancer 2014. doi:10.1002/pbc.24730.Google Scholar
Pashankar, F, Frazier, AL, Krailo, M, et al. Treatment of refractory germ cell tumors in children with paclitaxel, ifosfamide, and carboplatin: a report from the Children’s Oncology Group AGCT0521 study. Pediatr Blood Cancer 2018;65.Google Scholar
Motzer, RJ, Mazumdar, M, Sheinfeld, J, et al. Sequential dose-intensive paclitaxel, ifosfamide, carboplatin, and etoposide salvage therapy for germ cell tumor patients. J Clin Oncol 2000. doi:10.1200/JCO.2000.18.6.1173.Google Scholar
Fenner, MH, Beutel, G, Grünwald, V. Targeted therapies for patients with germ cell tumors. Expert Opin Investig Drugs 2008. doi:10.1517/13543784.17.4.511.Google Scholar
Wessalowski, R, Schneider, DT, Mils, O, et al. Regional deep hyperthermia for salvage treatment of children and adolescents with refractory or recurrent non-testicular malignant germ-cell tumours: an open-label, non-randomised, single-institution, phase 2 study. Lancet Oncol 2013. doi:10.1016/S1470-2045(13)70271-7.Google Scholar
Hayes-Jordan, A, Lopez, C, Green, HL, et al. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in pediatric ovarian tumors: a novel treatment approach. Pediatr Surg Int 2016. doi:10.1007/s00383-015–3814-9.CrossRefGoogle Scholar
Dicken, BJ, Billmire, DF, Krailo, M, et al. Gonadal dysgenesis is associated with worse outcomes in patients with ovarian nondysgerminomatous tumors: a report of the Children’s Oncology Group AGCT 0132 study. Pediatr Blood Cancer 2018. doi:10.1002/pbc.26913.Google Scholar

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