Digitalization has been a driver of transformation in business and society, leading to radical changes in the ideas and shapes of what work is, what organizations are and how value can be captured and created. One of the key issues of digitalization has been its capacity to enforce new ecosystems and the consequent rise of a new breed of entrepreneurs and ventures exploiting the opportunity of digital business. Therefore, this book discusses and presents the main challenges and trends related to digital entrepreneurship to an audience of managers and scholars. Moreover, this volume aims to provide a unified survey of both practice and current scientific work on the topic, considering the key issues for strategy and management as well as the role of technology in developing new digital ventures. Thus, as in my previous volumes, I will consider different perspectives, from information systems, technology management and innovation research to strategy and marketing, among others.