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Chapter 16 - Plasma Cell Neoplasia

Published online by Cambridge University Press:  12 November 2020

Jon van der Walt ,
Attilio Orazi  and
Daniel A. Arber
By
Falko Fend
Jon van der Walt
Affiliation:
St Thomas’ Hospital, London
Attilio Orazi
Affiliation:
Texas Tech University
Daniel A. Arber
Affiliation:
University of Chicago
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Summary

Plasma cell neoplasms are derived from mature, IG heavy chain class-switched terminally differentiated B-cells, which usually secrete a monoclonal immunoglobulin or M-protein and consist of a homogeneous population of neoplastic plasma cells [1]. Plasma cell myeloma (PCM) is a common malignancy, manifesting itself by bone marrow (BM) infiltration and bone destruction, and therefore representing an entity frequently encountered in BM biopsies(BMB). Its precursor lesion, non-IgM monoclonal gammopathy of unknown significance (MGUS) is a frequent finding in elderly individuals and shows a low, but definite risk for progression to PCM. In this chapter, we will discuss the diagnosis and differential diagnosis of PCM, MGUS and clonal plasma cell disorders with associated paraneoplastic syndromes, including POEMS syndrome and TEMPI syndrome. Amyloidosis is discussed in Chapter 3, and other mature B-cell neoplasms with a clonal plasma cell component in Chapter 15.

Keywords

Plasma cellplasmacytosismonoclonal gammopathymyelomaplamablasticleukaemiaamyloidPOEMS
Type
Chapter
Information
Diagnostic Bone Marrow Haematopathology , pp. 283 - 297
Publisher: Cambridge University Press
Print publication year: 2021

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