Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-76fb5796d-2lccl Total loading time: 0 Render date: 2024-04-26T09:44:50.027Z Has data issue: false hasContentIssue false

Chapter 11 - Developmental Origins of Chronic Respiratory Diseases

from Section III - Outcomes

Published online by Cambridge University Press:  01 December 2022

By
Liesbeth Duijts ,
Annemiek Mian ,
Tarik Karramass  and
Vincent W. V. Jaddoe
Edited by
Lucilla Poston ,
Keith M. Godfrey ,
Peter D. Gluckman  and
Mark A. Hanson
Lucilla Poston
Affiliation:
King's College London
Keith M. Godfrey
Affiliation:
University of Southampton
Peter D. Gluckman
Affiliation:
University of Auckland
Mark A. Hanson
Affiliation:
University of Southampton
Get access

Summary

Chronic obstructive respiratory diseases, including asthma, are common and a major public health problem. Childhood asthma is associated with increased risks of chronic obstructive respiratory diseases in later adult life. This chapter describes the origins of chronic obstructive respiratory diseases in relation to genetic susceptibility, environmental exposures and their interactions preconceptionally, in utero and postnatally. Asthma in childhood has a strong hereditable component, and genome-wide association studies have identified >400 different genetic variants associated with childhood asthma. Additionally, large-scale epidemiological studies have identified important and potentially modifiable early life exposures related to growth, lifestyle and microbial factors associated with risk of asthma development. Epigenome wide studies focussed on DNA methylation could infer a mechanistic link between these early life exposures and childhood asthma risk. Causality and underlying mechanisms of these associations, as well as potential interactions, need to be further explored. Ultimately, improved mechanistic understanding will inform early life intervention strategies with potential for optimizing later life respiratory health.

Type
Chapter
Information
Developmental Origins of Health and Disease , pp. 100 - 110
Publisher: Cambridge University Press
Print publication year: 2022

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Asher, MI, Rutter, CE, Bissell, K, Chiang, CY, El Sony, A, Ellwood, E et al. Global asthma network phase I study group. Worldwide trends in the burden of asthma symptoms in school-aged children: Global asthma network phase I cross-sectional study. Lancet. 2021 Oct 30;398(10311):1569–80. doi: 10.1016/S0140-6736(21)01450-1.Google Scholar
Tai, A, Tran, H, Roberts, M, Clarke, N, Wilson, J, Robertson, CF. The association between childhood asthma and adult chronic obstructive pulmonary disease. Thorax. 2014 Sep;69(9):805–10. PubMed PMID: 24646659. Epub 2014/03/22. eng.Google Scholar
Lange, P, Celli, B, Agusti, A, Boje Jensen, G, Divo, M, Faner, R, et al. Lung-function trajectories leading to chronic obstructive pulmonary disease. N Engl J Med. 2015 Jul 9;373(2):111–22. PubMed PMID: 26154786. Epub 2015/07/15. eng.Google Scholar
Postma, DS, Rabe, KF. The asthma-COPD overlap syndrome. N Engl J Med. 2015 Sep 24;373(13):1241–9. PubMed PMID: 26398072. Epub 2015/09/24. eng.Google Scholar
Chronic Obstructive Pulmonary Disease (COPD): World Health Organisation; 2015 [updated March 2015. Available from: http://www.who.int/mediacentre/factsheets/fs315/en/.Google Scholar
The Global Initiative for Asthma (GINA]. https://ginasthmaorg/gina-reports/. 2021.Google Scholar
Asher, MI, Garcia-Marcos, L, Pearce, NE, Strachan, DP. Trends in worldwide asthma prevalence. Eur Respir J. 2020 Sep 24. PubMed PMID: 32972987. Epub 2020/09/26. eng.Google Scholar
Dharmage, SC, Perret, JL, Custovic, A. Epidemiology of asthma in children and adults. Front Pediatr. 2019;7:246. PubMed PMID: 31275909. PMCID: 6591438. Epub 2019/07/06. eng.Google Scholar
Barker, DJ, Osmond, C, Law, CM. The intrauterine and early postnatal origins of cardiovascular disease and chronic bronchitis. J Epidemiol Community Health. 1989 Sep;43(3):237–40. PubMed PMID: 2607302. PMCID: 1052843. Epub 1989/09/01. eng.Google Scholar
Duijts, L, Reiss, IK, Brusselle, G, de Jongste, JC. Early origins of chronic obstructive lung diseases across the life course. Eur J Epidemiol. 2014 Dec;29(12):871–85. PubMed PMID: 25537319. Epub 2014/12/30. eng.Google Scholar
van Meel, ER, Jaddoe, VWV, Bonnelykke, K, de Jongste, JC, Duijts, L. The role of respiratory tract infections and the microbiome in the development of asthma: A narrative review. Pediatr Pulmonol. 2017 Oct;52(10):1363–70. PubMed PMID: 28869358. PMCID: 7168085. Epub 2017/09/05. eng.Google Scholar
Vehmeijer, FOL, Guxens, M, Duijts, L, El Marroun, H. Maternal psychological distress during pregnancy and childhood health outcomes: a narrative review. J Dev Orig Health Dis. 2019 Jun;10(3):274–85. PubMed PMID: 30378522. Epub 2018/11/01. eng.Google Scholar
Mensink-Bout, SM, van Meel, ER, de Jongste, JC, Annesi-Maesano, I, Aubert, AM, Bernard, JY, et al. Dietary inflammatory index and non-communicable disease risk: A narrative review. Nutrients. 2019 Aug 12;11(8):1873. PubMed PMID: 31408965. PMCID: 6722630. Epub 2019/08/15. eng.Google Scholar
den Dekker, HT, Sonnenschein-van der Voort, AMM, de Jongste, JC, Anessi-Maesano, I, Arshad, SH, Barros, H, et al. Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children. J Allergy Clin Immunol. 2016 Apr;137(4):1026–35. PubMed PMID: 26548843. Epub 2015/11/10. eng.Google Scholar
Turner, S. Perinatal programming of childhood asthma: early fetal size, growth trajectory during infancy, and childhood asthma outcomes. Clin Dev Immunol. 2012;2012:962923. PubMed PMID: 22400043. PMCID: 3287283. Epub 2012/03/09. eng.CrossRefGoogle Scholar
Mensink-Bout, SM, Santos, S, van Meel, ER, Oei, EHG, de Jongste, JC, Jaddoe, VWV, et al. General and organ fat assessed by magnetic resonance imaging and respiratory outcomes in childhood. Am J Respir Crit Care Med. 2020 Feb 1;201(3):348–55. PubMed PMID: 31597047. Epub 2019/10/10. eng.Google Scholar
Burke, H, Leonardi-Bee, J, Hashim, A, Pine-Abata, H, Chen, Y, Cook, DG, et al. Prenatal and passive smoke exposure and incidence of asthma and wheeze: systematic review and meta-analysis. Pediatrics. 2012 Apr;129(4):735–44. PubMed PMID: 22430451. Epub 2012/03/21. eng.Google Scholar
Silvestri, M, Franchi, S, Pistorio, A, Petecchia, L, Rusconi, F. Smoke exposure, wheezing, and asthma development: a systematic review and meta-analysis in unselected birth cohorts. Pediatr Pulmonol. 2015 Apr;50(4):353–62. PubMed PMID: 24648197. Epub 2014/03/22. eng.CrossRefGoogle Scholar
Lin, W, Brunekreef, B, Gehring, U. Meta-analysis of the effects of indoor nitrogen dioxide and gas cooking on asthma and wheeze in children. Int J Epidemiol. 2013 Dec;42(6):1724–37. PubMed PMID: 23962958. Epub 2013/08/22. eng.Google Scholar
Fuertes, E, Sunyer, J, Gehring, U, Porta, D, Forastiere, F, Cesaroni, G, et al. Associations between air pollution and pediatric eczema, rhinoconjunctivitis and asthma: A meta-analysis of European birth cohorts. Environ Int. 2020 Mar;136:105474. PubMed PMID: 31962272. Epub 2020/01/22. eng.Google Scholar
Hehua, Z, Qing, C, Shanyan, G, Qijun, W, Yuhong, Z. The impact of prenatal exposure to air pollution on childhood wheezing and asthma: A systematic review. Environ Res. 2017 Nov;159:519–30. PubMed PMID: 28888196. Epub 2017/09/10. eng.Google Scholar
Khreis, H, Cirach, M, Mueller, N, de Hoogh, K, Hoek, G, Nieuwenhuijsen, MJ, et al. Outdoor air pollution and the burden of childhood asthma across Europe. Eur Respir J. 2019 Oct;54(4). PubMed PMID: 31391220. Epub 2019/08/09. eng.Google Scholar
Mensink-Bout, SM, van Meel, ER, de Jongste, JC, Annesi-Maesano, I, Aubert, AM, Bernard, JY, et al. Maternal diet in pregnancy and child’s respiratory outcomes: an individual participant data meta-analysis of 18 000 children. Eur Respir J. 2021 Sep 9. PubMed PMID: 34503987. Epub 2021/09/11. eng.Google Scholar
Huang, L, Chen, Q, Zhao, Y, Wang, W, Fang, F, Bao, Y. Is elective cesarean section associated with a higher risk of asthma? A meta-analysis. J Asthma. 2015 Feb;52(1):16–25. PubMed PMID: 25162303. Epub 2014/08/28. eng.Google Scholar
Keag, OE, Norman, JE, Stock, SJ. Long-term risks and benefits associated with cesarean delivery for mother, baby, and subsequent pregnancies: Systematic review and meta-analysis. PLoS Med. 2018 Jan;15(1):e1002494. PubMed PMID: 29360829. PMCID: 5779640. Epub 2018/01/24. eng.Google Scholar
Rusconi, F, Zugna, D, Annesi-Maesano, I, Baiz, N, Barros, H, Correia, S, et al. Mode of delivery and asthma at school age in 9 European Birth Cohorts. Am J Epidemiol. 2017 Mar 15;185(6):465–73. PubMed PMID: 28399567. Epub 2017/04/12. eng.Google Scholar
Barker, DJ, Godfrey, KM, Fall, C, Osmond, C, Winter, PD, Shaheen, SO. Relation of birth weight and childhood respiratory infection to adult lung function and death from chronic obstructive airways disease. BMJ. 1991 Sep 21;303(6804):671–5. PubMed PMID: 1912913. PMCID: 1670943. Epub 1991/09/21. eng.Google Scholar
Blanken, MO, Rovers, MM, Molenaar, JM, Winkler-Seinstra, PL, Meijer, A, Kimpen, JL, et al. Respiratory syncytial virus and recurrent wheeze in healthy preterm infants. N Engl J Med. 2013 May 9;368(19):1791–9. PubMed PMID: 23656644.Google Scholar
Simoes, EA, Carbonell-Estrany, X, Rieger, CH, Mitchell, I, Fredrick, L, Groothuis, JR, et al. The effect of respiratory syncytial virus on subsequent recurrent wheezing in atopic and nonatopic children. J Allergy Clin Immunol. 2010 Aug;126(2):256–62. PubMed PMID: 20624638.Google Scholar
Zimmermann, P, Messina, N, Mohn, WW, Finlay, BB, Curtis, N. Association between the intestinal microbiota and allergic sensitization, eczema, and asthma: A systematic review. J Allergy Clin Immunol. 2019 Feb;143(2):467–85. PubMed PMID: 30600099. Epub 2019/01/03. eng.Google Scholar
Hu, C, van Meel, ER, Medina-Gomez, C, Kraaij, R, Barroso, M, Jong, JK, et al. A Population-based Study on Associations of Stool Microbiota with Atopic Diseases in School-age Children. J Allergy Clin Immunol. 2021 Apr 13. PubMed PMID: 33862008. Epub 2021/04/17. eng.Google Scholar
Palmer, LJ, Knuiman, MW, Divitini, ML, Burton, PR, James, AL, Bartholomew, HC, et al. Familial aggregation and heritability of adult lung function: results from the Busselton Health Study. Eur Respir J. 2001 Apr;17(4):696–702. PubMed PMID: 11401066. Epub 2001/06/13. eng.Google Scholar
El-Husseini, ZW, Gosens, R, Dekker, F, Koppelman, GH. The genetics of asthma and the promise of genomics-guided drug target discovery. Lancet Respir Med. 2020 Oct;8(10):1045–56. PubMed PMID: 32910899. Epub 2020/09/11. eng.Google Scholar
Qi, C, Xu, CJ, Koppelman, GH. The role of epigenetics in the development of childhood asthma. Expert Rev Clin Immunol. 2019 Dec;15(12):1287–302. PubMed PMID: 31674254. Epub 2019/11/02. eng.Google Scholar
Joubert, BR, den Dekker, HT, Felix, JF, Bohlin, J, Ligthart, S, Beckett, E, et al. Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns. Nat Commun. 2016;7:10577. PubMed PMID: 26861414. PMCID: 4749955. Epub 2016/02/11. eng.Google Scholar
Joubert, BR, Felix, JF, Yousefi, P, Bakulski, KM, Just, AC, Breton, C, et al. DNA Methylation in newborns and maternal smoking in pregnancy: Genome-wide Consortium meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680–96. PubMed PMID: 27040690. PMCID: 4833289. Epub 2016/04/05. eng.Google Scholar
den Dekker, HT, Burrows, K, Felix, JF, Salas, LA, Nedeljkovic, I, Yao, J, et al. Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course. Eur Respir J. 2019 Apr;53(4):1801795. PubMed PMID: 30765504. Epub 2019/02/16. eng.Google Scholar
Guxens, M, Sonnenschein-van der Voort, AM, Tiemeier, H, Hofman, A, Sunyer, J, de Jongste, JC, et al. Parental psychological distress during pregnancy and wheezing in preschool children: the Generation R Study. J Allergy Clin Immunol. 2014 Jan;133(1):59–67 e1–12. PubMed PMID: 23777854. Epub 2013/06/20. eng.Google Scholar
Lundholm, C, Gunnerbeck, A, D’Onofrio, BM, Larsson, H, Pershagen, G, Almqvist, C. Smoking and snuff use in pregnancy and the risk of asthma and wheeze in pre-schoolchildren-A population-based register study. Clin Exp Allergy. 2020 May;50(5):597–608. PubMed PMID: 32149429. Epub 2020/03/10. eng.Google Scholar
Granell, R, Henderson, AJ, Evans, DM, Smith, GD, Ness, AR, Lewis, S, et al. Effects of BMI, fat mass, and lean mass on asthma in childhood: a Mendelian randomization study. PLoS Med. 2014 Jul;11(7):e1001669. PubMed PMID: 24983943. PMCID: 4077660. Epub 2014/07/02. eng.Google Scholar
Wolsk, HM, Chawes, BL, Litonjua, AA, Hollis, BW, Waage, J, Stokholm, J, et al. Prenatal vitamin D supplementation reduces risk of asthma/recurrent wheeze in early childhood: A combined analysis of two randomized controlled trials. PLoS One. 2017;12(10):e0186657. PubMed PMID: 29077711. PMCID: 5659607. Epub 2017/10/28. eng.Google Scholar
Sears, MR. Predicting asthma outcomes. J Allergy Clin Immunol. 2015 Oct;136(4):829–36; quiz 37. PubMed PMID: 26449797. Epub 2015/10/10. eng.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×