Book contents
- Frontmatter
- Contents
- Contributors
- Case studies
- Preface to the second edition
- Preface to the first edition
- Abbreviations
- Introduction
- Section 1 Physiological MR techniques
- Chapter 1 Fundamentals of MR spectroscopy
- Chapter 2 Quantification and analysis in MR spectroscopy
- Chapter 3 Artifacts and pitfalls in MR spectroscopy
- Chapter 4 Fundamentals of diffusion MR imaging
- Chapter 5 Human white matter anatomical information revealed by diffusion tensor imaging and fiber tracking
- Chapter 6 Artifacts and pitfalls in diffusion MR imaging
- Chapter 7 Cerebral perfusion imaging by exogenous contrast agents
- Chapter 8 Detection of regional blood flow using arterial spin labeling
- Chapter 9 Imaging perfusion and blood–brain barrier permeability using T1-weighted dynamic contrast-enhanced MR imaging
- Chapter 10 Susceptibility-weighted imaging
- Chapter 11 Artifacts and pitfalls in perfusion MR imaging
- Chapter 12 Methodologies, practicalities and pitfalls in functional MR imaging
- Section 2 Cerebrovascular disease
- Section 3 Adult neoplasia
- Section 4 Infection, inflammation and demyelination
- Section 5 Seizure disorders
- Section 6 Psychiatric and neurodegenerative diseases
- Section 7 Trauma
- Section 8 Pediatrics
- Section 9 The spine
- Index
- References
Chapter 9 - Imaging perfusion and blood–brain barrier permeability using T1-weighted dynamic contrast-enhanced MR imaging
from Section 1 - Physiological MR techniques
Published online by Cambridge University Press: 05 March 2013
- Frontmatter
- Contents
- Contributors
- Case studies
- Preface to the second edition
- Preface to the first edition
- Abbreviations
- Introduction
- Section 1 Physiological MR techniques
- Chapter 1 Fundamentals of MR spectroscopy
- Chapter 2 Quantification and analysis in MR spectroscopy
- Chapter 3 Artifacts and pitfalls in MR spectroscopy
- Chapter 4 Fundamentals of diffusion MR imaging
- Chapter 5 Human white matter anatomical information revealed by diffusion tensor imaging and fiber tracking
- Chapter 6 Artifacts and pitfalls in diffusion MR imaging
- Chapter 7 Cerebral perfusion imaging by exogenous contrast agents
- Chapter 8 Detection of regional blood flow using arterial spin labeling
- Chapter 9 Imaging perfusion and blood–brain barrier permeability using T1-weighted dynamic contrast-enhanced MR imaging
- Chapter 10 Susceptibility-weighted imaging
- Chapter 11 Artifacts and pitfalls in perfusion MR imaging
- Chapter 12 Methodologies, practicalities and pitfalls in functional MR imaging
- Section 2 Cerebrovascular disease
- Section 3 Adult neoplasia
- Section 4 Infection, inflammation and demyelination
- Section 5 Seizure disorders
- Section 6 Psychiatric and neurodegenerative diseases
- Section 7 Trauma
- Section 8 Pediatrics
- Section 9 The spine
- Index
- References
Summary
Introduction
T1-weighted dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) is an experimental technique designed to measure tissue hemodynamic parameters.[1–3] For this purpose, contrast medium (the tracer) is rapidly injected intravenously. The passage of the bolus through the tissue causes changes in the longitudinal relaxation rate R1 (1/T1) that are measured with a dynamic T1-weighted imaging technique (Fig. 9.1). The principles of MRI signal theory are used to determine tracer concentration–time curves from the measured signal changes. In a second step, tracer kinetic principles [4,5] are applied to derive the relevant perfusion and/or blood–brain barrier (BBB) permeability parameters.
Perfusion and permeability parameters
Perfusion parameters characterize the state of the microvasculature (Fig. 9.2). Cerebral blood flow (CBF) quantifies tissue perfusion and is conventionally expressed in units of milliliters of blood per minute per 100 g tissue. Cerebral blood volume (CBV) quantifies the volume of the microvasculature and has the units of milliliters of blood per 100 g tissue. Compared with other organs, normal brain tissue is characterized by low blood volumes, with CBV in the range 2–4 ml/100 g.[6]
- Type
- Chapter
- Information
- Clinical MR NeuroimagingPhysiological and Functional Techniques, pp. 113 - 128Publisher: Cambridge University PressPrint publication year: 2009
References
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