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Case 23: - Two ladies with bruises

Published online by Cambridge University Press:  03 April 2024

Nevena V. Radonjić
Affiliation:
State University of New York Upstate Medical University
Thomas L. Schwartz
Affiliation:
State University of New York Upstate Medical University
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

Selective serotonin reuptake inhibitors (SSRIs) mainly affect the platelets by which of the following?

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Publisher: Cambridge University Press
Print publication year: 2024

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References

Andrade, C. Selective serotonin reuptake inhibitor use in pregnancy and risk of postpartum hemorrhage. J Clin Psychiatry 2022; 83(2):22f14455CrossRefGoogle ScholarPubMed
Anglin, R, Yuan, Y, Moayyedi, P, et al. Risk of upper gastrointestinal bleeding with selective serotonin reuptake inhibitors with or without concurrent nonsteroidal anti-inflammatory use: a systematic review and meta-analysis. Am J Gastroenterol 2014; 109: 811–19CrossRefGoogle ScholarPubMed
Brazell, C, McClue, SJ, Preston, GC, et al. 5-Hydroxytryptamine (5-HT)-induced shape change in human platelets determined by computerized data acquisition: correlation with [125I]-iodoLSD binding at 5-HT2 receptors. Blood Coagul Fibrinolysis 1991; 2:1724CrossRefGoogle Scholar
Dalton, SO, Johansen, C, Mellemkjaer, L, et al. Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding: a population-based cohort study. Arch Intern Med 2003; 163:5964CrossRefGoogle ScholarPubMed
Halperin, D, Reber, G. Influence of antidepressants on hemostasis. Dialogues Clin Neurosci 2007; 9:4759CrossRefGoogle ScholarPubMed
Jiang, HY, Chen, HZ, Hu, XJ, et al. Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal bleeding: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 2015; 13:4250.e43CrossRefGoogle ScholarPubMed
Maclean, JA, Schoenwaelder, SM. Serotonin in platelets. In Pilowsky, M, ed., Serotonin: The Mediator that Spans Evolution. Boston: Academic Press, 2019, 91119CrossRefGoogle Scholar
McCloskey, DJ, Postolache, TT, Vittone, BJ, et al. Selective serotonin reuptake inhibitors: measurement of effect on platelet function. Transl Res 2008; 151:168–72CrossRefGoogle ScholarPubMed
Meijer, WEE, Heerdink, ER, Nolen, WA, et al. Association of risk of abnormal bleeding with degree of serotonin reuptake inhibition by antidepressants. Arch Intern Med 2004; 164:2367–70CrossRefGoogle ScholarPubMed
Nochaiwong, S, Ruengorn, C, Awiphan, R, et al. Use of serotonin reuptake inhibitor antidepressants and the risk of bleeding complications in patients on anticoagulant or antiplatelet agents: a systematic review and meta-analysis. Ann Med 2022; 54:8097CrossRefGoogle ScholarPubMed
Perahia, DG, Bangs, ME, Zhang, Q, et al. The risk of bleeding with duloxetine treatment in patients who use nonsteroidal anti-inflammatory drugs (NSAIDs): analysis of placebo-controlled trials and post-marketing adverse event reports. Drug Healthc Patient Saf 2013; 5:211–19Google ScholarPubMed
Quinn, GR, Hellkamp, AS, Hankey, GJ, et al. Selective serotonin reuptake inhibitors and bleeding risk in anticoagulated patients with atrial fibrillation: an analysis from the ROCKET AF Trial. J Am Heart Assoc 2018; 7:e008755CrossRefGoogle ScholarPubMed
Renoux, C, Vahey, S, Dell’Aniello, S, et al. Association of selective serotonin reuptake inhibitors with the risk for spontaneous intracranial hemorrhage. JAMA Neurology 2017; 74:173–80Google ScholarPubMed
Rudnick, G. SERT, Serotonin Transporter. New York: Elsevier, 2007CrossRefGoogle Scholar
Samuel, NG, Seifert, CF. Risk of bleeding in patients on full-dose enoxaparin with venous thromboembolism and selective serotonin reuptake inhibitors. Ann Pharmacother 2017; 51:226–31CrossRefGoogle ScholarPubMed
Song, HR, Jung, Y-E, Wang, H-R, et al. Platelet count alterations associated with escitalopram, venlafaxine and bupropion in depressive patients. Psychiatry Clin Neurosci 2012; 66:457–9CrossRefGoogle ScholarPubMed

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