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Chapter 18 - Stroke prevention

from Part III - Prevention, complications, and recovery–rehabilitation

Published online by Cambridge University Press:  05 August 2016

Louis R. Caplan
Affiliation:
Department of Neurology, Beth Israel Deaconess Medical Center, Massachusetts
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Caplan's Stroke
A Clinical Approach
, pp. 567 - 593
Publisher: Cambridge University Press
Print publication year: 2016

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References

Pasteur, L: Address to the Fraternal Association of Former Students of the École Centrale des Arts et Manufactures. Paris, May 15, 1884.Google Scholar
Sug, YS, Heller, RF, Levi, C, et al: Knowledge of stroke risk factors, warning symptoms, and treatment among an Australian urban population. Stroke 2001;32:19261930.Google Scholar
Schneider, AT, Pancioli, AM, Khoury, JC, et al: Trends in community knowledge of the warning signs and risk factors for stroke. JAMA 2003;289:343346.CrossRefGoogle ScholarPubMed
Kothari, R, Sauerbeck, L, Jauch, E, et al: Patients’ awareness of stroke signs, symptoms, and risk factors. Stroke 1997;28:18711875.CrossRefGoogle ScholarPubMed
Pandian, JD, Jaison, A, Deepak, SS, et al: Public awareness of warning symptoms, risk factors, and treatment of stroke in northwest India. Stroke 2005;36:644648.Google Scholar
Maasland, L, Koudstaal, PJ, Habbema, JD, Dippel, DW: Knowledge and understanding of disease process, risk factors and treatment modalities in patients with a recent TIA or minor ischemic stroke. Cerebrovasc Dis 2007;23:435440.Google Scholar
Nedeltchev, K, Fischer, U, Arnold, M, et al: Low awareness of transient ischemic attacks and risk factors for stroke in a Swiss urban community. J Neurol 2007;254:179184.CrossRefGoogle Scholar
Anderson, BE, Rafferty, AP, Lyon-Callo, S, Fussman, C, Reeves, MJ: Knowledge of tissue plasminogen activator for acute stroke among Michigan adults. Stroke 2009;40:25642567.CrossRefGoogle ScholarPubMed
Fussman, C, Rafferty, AP, Lyon-Callo, , Morgenstern, LB, Reeves, MJ: Lack of association between stroke symptom knowledge and intent to call 911. A population-based study. Stroke 2010;41:15011507Google Scholar
Garraway, WM, Whisnant, JP, Furlan, AJ, et al: The declining incidence of stroke. N Engl J Med 1979;300:449452.Google Scholar
Bonita, R, Stewart, A, Beaglehole, R: International trends in stroke mortality: 1970–1985. Stroke 1990;21:989992.Google Scholar
Sytkowski, PA, Kannel, WB, D’Agostino, RB: Changes in risk factors and the decline in mortality from cardiovascular disease. N Engl J Med 1990;322:16351641.CrossRefGoogle ScholarPubMed
Lackland, DT, Roccella, E, Deutsch, AF, et al: Factors influencing the decline in stroke mortality. A Statement From the American Heart Association/American Stroke Association. Stroke 2013; published online before print Dec. 5, 2013, doi: 10.1161/01.str.0000437068.30550.cf.CrossRefGoogle Scholar
Caplan, LR, Dyken, ML, Easton, JD: American Heart Association Family Guide to Stroke Treatment, Recovery, and Prevention. New York: Random House–Times Books, 1994.Google Scholar
Hutton, C, Caplan, LR: Striking Back at Stroke: A Doctor–Patient Journal. New York: Dana Press, 2003.Google Scholar
Caplan, LR: Stroke. New York: Demos–American Academy of Neurology, 2005.Google Scholar
Caplan, LR: Navigating the Complexities of Stroke. New York, Oxford University Press, 2013.Google Scholar
Gorelick, PB: The future of stroke prevention by risk factor modification. Handb Clin Neurol 2009;94:12611276.CrossRefGoogle ScholarPubMed
Wald, NJ, Law, MR: A strategy to reduce cardiovascular disease by more than 80%. BMJ 2003;326:1419.Google Scholar
Gorelick, PB: New horizons for stroke prevention: PROGRESS and HOPE. Lancet Neurol 2002;1:149156.Google Scholar
Lawes, CMM, Bennett, DA, Feigin, VL, Rogers, A: Blood pressure and stroke. An overview of published reviews. Stroke 2004;35:10241033.Google Scholar
Sacco, RL: The 2006 William Feinberg lecture. Shifting the paradigm from stroke to global vascular risk estimation. Stroke 2007;38:19801987.Google Scholar
Wolf, P, Dyken, M, Barnett, HJM, et al: Risk factors in stroke. Stroke 1984;15:11051111.Google Scholar
Shaper, AG, Phillips, AN, Pocock, SJ, et al: Risk factors for stroke in middle-aged British men. BMJ 1991;302:11111115.Google Scholar
Matchar, DB, McCrory, DC, Barnett, HJM, Feussner, JR: Medical treatment for stroke prevention. Ann Intern Med 1994;121:4153.Google Scholar
Bronner, LL, Kanter, DS, Manson, JE: Primary prevention of stroke. N Engl J Med 1995;333:13921400.CrossRefGoogle ScholarPubMed
Kalra, L, Perez, I, Melbourn, A: Stroke risk management. Change in mainstream practice. Stroke 1998;29:5357.Google Scholar
Gorelick, PB, Sacco, RL, Smith, DB, et al: Prevention of a first stroke. A review of guidelines and a multidisciplinary consensus statement from the National Stroke Association. JAMA 1999;281:11121120.Google Scholar
Whisnant, JP: Stroke Populations, Cohorts, and Clinical Trials. Boston: Butterworth–Heinemann, 1993.Google Scholar
Dorndorf, W, Marx, P: Stroke Prevention. Basel: Karger, 1994.Google Scholar
Norris, JW, Hachinski, VC: Prevention of Stroke. New York: Springer, 1991.Google Scholar
Gorelick, PB, Alter, M: The Prevention of Stroke. Boca Raton, FL: Parthenon Publishing Group, 2002.CrossRefGoogle Scholar
Go, AS, Mozaffarian, D, Roger, VL, et al: Heart disease and stroke statistics – 2014 update. A report from the American Heart Association. Circulation 2014;129:e28e292.Google Scholar
Sobel, E, Altu, M, Davanipour, Z, et al: Stroke in the Lehigh Valley: Combined risk factors for recurrent ischemic stroke. Neurology 1989;39:669672.Google Scholar
Davis, PH, Dambrosia, JM, Schoenberg, BS, et al: Risk factors for ischemic stroke: A prospective study in Rochester, Minnesota. Ann Neurol 1987;22:319327.Google Scholar
Simons, LA, McCallum, J, Friedlander, Y, Simons, J: Risk factors for ischemic stroke. Dubbo study of the elderly. Stroke 1998;29:13411346.Google Scholar
Whisnant, JP, Wiebers, DO, O’Fallon, WM, et al: A population-based model of risk factors for ischemic stroke: Rochester, Minnesota. Neurology 1996;47:14201428.Google Scholar
Sacco, RL: Risk factors, outcomes, and stroke subtypes for ischemic stroke. Neurology 1997;49(suppl 4):S39S44.Google Scholar
Goldstein, LB, Adams, R, Becker, K, et al: Primary prevention of ischemic stroke: A statement for healthcare professionals from the Stroke Council of the American Heart Association. Stroke 2001;32:280299.Google Scholar
Johnson, P, Rosewell, M, James, MA: How good is the management of vascular risk after stroke, transient ischemic attack, or carotid endarterectomy? Cerebrovasc Dis 2007;32:156161.Google Scholar
Romero, JR: Prevention of ischemic stroke: Overview of traditional risk factors. Curr Drug Targets 2007;8:794801.Google Scholar
Longstreth, WT, Koepsell, T, Yerby, M, et al: Risk factors for subarachnoid hemorrhage. Stroke 1985;16:377385.Google Scholar
Teunissen, LL, Rinkel, GJE, Algra, A, van Gijn, J: Risk factors for subarachnoid hemorrhage. A systematic review. Stroke 1996;27:544549.Google Scholar
Qureshi, AI, Suri, MF, Yahia, AM, et al: Risk factors for subarachnoid hemorrhage. Neurosurgery 2001;49:607612.Google Scholar
Isaksen, J, Egge, A, Waterloo, K, et al: Risk factors for aneurysmal subarachnoid haemorrhage: The Tromso study. J Neurol Neurosurg Psychiatry 2002;73:185187.Google Scholar
Ohkuma, H, Tabata, H, Suzuki, S, Islam, S: Risk factors for aneurysmal subarachnoid hemorrhage in Aomori, Japan. Stroke 2003;34:96100.Google Scholar
Broderick, JP: Intracerebral hemorrhage. In Gorelick, PB, Alter, M (eds): Handbook of Neuroepidemiology. New York: Marcel Dekker, 1994, pp 141167.Google Scholar
Qureshi, AI, Suri, MA, Safdar, K, et al: Intracerebral hemorrhage in blacks: Risk factors, subtypes, and outcome. Stroke 1997;28:961964.Google Scholar
Bateman, BT, Schumacher, HC, Bushnell, CD, et al: Intracerebral hemorrhage in pregnancy: Frequency, risk factors, and outcome. Neurology 2006;67:424429.Google Scholar
Mitchell, P, Mitra, D, Gregson, BA, Mendelow, AD: Prevention of intracerebral haemorrhage. Curr Drug Targets 2007;8:832838.Google Scholar
Caplan, LR: Brain embolism. In Caplan, LR, Hurst, JW, Chimowitz, M (eds): Clinical Neurocardiology. New York: Marcel Dekker, 1999, pp 35185.Google Scholar
Caplan, LR, Manning, WJ: Brain Embolism. New York: Informa Healthcare, 2006.Google Scholar
Gorelick, PB, Caplan, LR, Hier, DB, et al: Racial differences in the distribution of anterior circulation occlusive cerebrovascular disease. Neurology 1984;34:5459.Google Scholar
Gorelick, PB, Caplan, LR, Hier, DB, et al: Racial differences in the distribution of posterior circulation occlusive disease. Stroke 1985;16:785790.Google Scholar
Caplan, LR: Race, sex, and occlusive cerebrovascular disease: A review. Stroke 1986;17:648655.Google Scholar
Caplan, LR: Cerebral ischemia and infarction in blacks. Clinical, autopsy, and angiographic studies. In Gillum, RF, Gorelick, PB, Cooper, ES (eds): Stroke in Blacks. Basel: Karger, 1999, pp 718.Google Scholar
White, H, Boden-Albala, B, Wang, C, et al: Ischemic stroke subtype incidence among whites, blacks, and Hispanics: The Northern Manhattan Study. Circulation 2005;111:13271331.Google Scholar
Sacco, RL, Kargman, DE, Gu, Q, Zamanillo, MC: Race-ethnicity and determinants of intracranial atherosclerotic cerebral infarction. The Northern Manhattan Stroke Study. Stroke 1995;26:1420.Google Scholar
Lewington, S, Clarke, R, Qizilbash, N, et al: Age-specific relevance of usual blood pressure to vascular mortality: A meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002;360:19031913.Google Scholar
Kannel, WB: Current status of the epidemiology of brain infarction associated with occlusive vascular disease. Stroke 1971;2:295318.CrossRefGoogle Scholar
Mackay, MT, Wiznitzer, M, Benedict, SL, et al: Arterial ischemic stroke risk factors: The International Pediatric Stroke Study. Ann Neurol 2011;69:130140.Google Scholar
Gebel, J, Broderick, J: Primary intracerebral hemorrhage and subarachnoid hemorrhage in black patients: Risk factors, diagnosis, and prognosis. In Gillum, RF, Gorelick, PB, Cooper, ES (eds): Stroke in Blacks. Basel: Karger, 1999, pp 2935.Google Scholar
Towfighi, A, Zheng, L, Obviagele, B: Weight of the obesity epidemic. Rising stroke rates among middle-aged women in the United States. Stroke 2010;41:13711375.Google Scholar
Kiely, DK, Wolf, PA, Cupples, LA, et al: Family aggregation of stroke: The Framingham Study. Stroke 1993;24:13661371.Google Scholar
Liao, D, Myers, R, Hunt, S, et al: Family history of stroke and stroke risk. The Family Heart Study. Stroke 1997;28:19081912.Google Scholar
Wannamethee, SG, Shaper, AG, Ebrahim, S: History of parental death from stroke or heart trouble and the risk of stroke in middle-aged men. Stroke 1996;27:14921498.Google Scholar
Jousilahri, P, Rastenyte, D, Tuomilehto, J, et al: Parental history of cardiovascular disease and risk of stroke. A prospective follow-up of 14,371 middle-aged men and women in Finland. Stroke 1997;28:13611366.Google Scholar
Meschia, JF, Case, LD, Worrall, BB, et al: Ischemic Stroke Genetics Study Group. Family history of stroke and severity of neurologic deficit after stroke. Neurology 2006;67:13961402.Google Scholar
McGill, HC, Arias-Stella, J, Carbonell, LM, et al: General findings of the International Atherosclerosis Project. Lab Invest 1968;18:498502.Google Scholar
Solberg, LA, McGarry, PA, Moosy, J, et al: Distribution of cerebral atherosclerosis by geographic location, race, and sex. Lab Invest 1968;158:604612.Google Scholar
Freedman, DS, Khan, LK, Dietz, WH, Srinivasan, SR, Berenson, G: Relationship of obesity in childhood to coronary heart disease risk factors in adulthood: The Bogalusa Heart Study. Pediatrics 2001;108:712718.Google Scholar
Högström, G, Nordström, A, Eriksson, M, Nordström, P: Risk factors assessed in adolescence and the later risk of stroke in men: a 33-year follow-up study. Cerebrovasc Dis 2015;39:6371.Google Scholar
Expert Panel. Summary Report on Integrated Guidelines of Cardiovascular Health and Risk Reduction in Children and Adolescents. Bethesda, MD: US Department of Health and Human Services, National Heart, Lung and Blood Institute, NIH Publication No. 12–7486A, October 2012, pp 172.Google Scholar
Reis, JP, Loria, CM, Lewis, CE, et al: Association between duration of overall and abdominal obesity beginning in young adulthood and coronary artery calcification in middle age. JAMA 2013;310:280288.Google Scholar
Kannel, WB: Blood pressure as a cardiovascular risk factor. JAMA 1996;275:15711576.Google Scholar
National Heart, Lung, and Blood Institute: Working Group Report on Primary Prevention of Hypertension: National High Blood Pressure Education Program. NHLBI Doc 93–2669. Bethesda, MD: National Institutes of Health, 1993.Google Scholar
Chobanian, AV, Bakris, GL, Black, HR, et al: The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. JAMA 2003;289:25602572.Google Scholar
Go, AS, Mozaffarinan, D, Roger, VL, et al. on behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics – 2013 update, a report from the American Heart Association. Circulation 2013;127:e6e245.Google Scholar
Prospective Studies Collaboration: Age-specific relevance of usual blood pressure to vascular mortality: A meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002;360:19031913.Google Scholar
Gueyffier, F, Bulpitt, C, Boissel, J-P, et al: Antihypertensive drugs in very old people: A subgroup meta-analysis of randomized controlled trials. Lancet 1999;353:793796.Google Scholar
Howard, G, Manolio, TA, Burke, GL, et al: Does the association of risk factors and atherosclerosis change with age? Stroke 1997;28:16931701.Google Scholar
Beckett, NS, Peters, R, Fletcher, AE, et al: Treatment of hypertension in patients 80 years of age or older. HYVET Study Group. N Engl J Med 2008;358:18871898.Google Scholar
SHEP Cooperative Research Group: Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. JAMA 1991;265:32553264.Google Scholar
Sutton-Tyrrell, K, Alcorn, HG, Herzog, H, et al: Morbidity, mortality, and antihypertensive treatment effects by extent of atherosclerosis in older adults with isolated systolic hypertension. Stroke 1995;26:13191324.Google Scholar
Davis, BR, Vogt, T, Frost, PH, et al: Risk factors for stroke and type of stroke in persons with isolated systolic hypertension. The Systolic Hypertension in the Elderly Program (SHEP) Research Group. Stroke 1998;29:13331340.Google Scholar
Perry, HM, Davis, BR, Price, TR, et al: Effect of treating isolated systolic hypertension on the risk of developing various types and subtypes of stroke. Systolic Hypertension in the Elderly Program (SHEP) Cooperative Research Group. JAMA 2000;284:465471.Google Scholar
Staessen, JA, Gasowski, J, Wang, JG, et al: Risks of untreated and treated isolated systolic hypertension in the elderly: Meta-analysis of outcome trials. Lancet 2000;355:865872.Google Scholar
Bowman, TS, Gaziano, JM, Kase, CS, et al: Blood pressure measures and risk of total, ischemic, and hemorrhagic stroke in men. Neurology 2006;67:820823.Google Scholar
Chobanian, AV: Isolated systolic hypertension in the elderly. N Engl J Med 2007;357:789796.Google Scholar
Wenger, NK: Hypertension and other cardiovascular risk factors in women. Am J Hypertens 1995;8:94S99S.Google Scholar
Rothwell, PM, Coull, AJ, Silver, LE, et al: Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study). Lancet 2005;366:17731783.CrossRefGoogle ScholarPubMed
Mitchell, GF, Ramachandran, SV, Keyes, MJ, et al: Pulse-pressure and risk of new-onset atrial fibrillation. JAMA 2007;297;709715.Google Scholar
Weitzman, D, Goldbourt, U: The significance of various blood pressure indices for long-term stroke, coronary heart disease, and all-cause mortality in men. The Israeli Ischemic Heart Disease Study. Stroke 2006;37:358363.Google Scholar
Paultre, F, Mosca, L: Association of blood pressure indices and stroke mortality in isolated systolic hypertension. Stroke 2005;36:12881290.Google Scholar
Vemmos, KN, Tsivgoulis, G, Spengos, K, et al: Pulse pressure in acute stroke is an independent predictor of long-term mortality. Cerebrovasc Dis 2004;18:3036.Google Scholar
Rothwell, PM: Limitations of the usual blood pressure hypothesis and importance of variability, instability, and episodic hypertension. Lancet 2010;375:938948.Google Scholar
Gorelick, PB: Reducing blood pressure variability to prevent stroke? Lancet Neurol 2010;9:448449.CrossRefGoogle ScholarPubMed
Watanabe, N, Imai, Y, Nagai, K, et al: Nocturnal blood pressure and silent cerebrovascular lesions in elderly Japanese. Stroke 1996;27:13191327.Google Scholar
Yamamoto, Y, Akiguchi, I, Oiwa, K, et al: Adverse effect of nighttime blood pressure on the outcome of lacunar infarct patients. Stroke 1998;29:570576.Google Scholar
Lip, GY, Zarifis, J, Farooqi, S, et al: Ambulatory blood pressure monitoring in acute stroke. The West Birmingham Stroke Project. Stroke 1997;28:3135.Google Scholar
Staessen, JA, Thijs, L, Fagard, R, et al: Predicting cardiovascular risk using conventional vs. ambulatory blood pressure in older patients with systolic hypertension. Systolic Hypertension in the Europe Trial Investigators. JAMA 1999;282:539546.Google Scholar
Goldstein, IB, Bartzokis, G, Guthrie, D, Shapiro, D: Ambulatory blood pressure and the brain. A 5-year follow-up. Neurology 2005;64:18461852.Google Scholar
Tsivgoulis, G, Spengos, K, Zakopoulos, N, et al: Twenty-four-hour pulse pressure predicts long-term recurrence in acute stroke patients. J Neurol Neurosurg Psychiatry 2005;76:13601365.Google Scholar
Rashid, P, Leonardi-Bee, J, Bath, P: Blood pressure reduction and secondary prevention of stroke and other vascular events. A systematic review. Stroke 2003;34:27412749.Google Scholar
Psaty, BM, Lumley, T, Furberg, CD, et al: Health outcomes associated with various antihypertensive therapies used as first-line agents. JAMA 2003;289:25342544.Google Scholar
Blood Pressure Lowering Treatment Trialists’ Collaboration: Effects of different blood-pressure-lowering regimens on major cardiovascular events: Results of prospectively-designed overviews of randomized trials. Lancet 2003;362:15271535.Google Scholar
Hall, WD, Kong, W: Hypertension in blacks: Nonpharmacologic and pharmacologic therapy. In Saunders, E (ed): Cardiovascular Disease in Blacks. Philadelphia: FA Davis, 1991, pp 157169.Google Scholar
Rajagopalan, S, Harrison, D: Reversing endothelial dysfunction with ACE inhibitors. A new trend? Circulation 1996;94:240243.Google Scholar
Bosch, J, Yusuf, S, Pogue, J, et al: Use of ramipril in preventing stroke: Double blind randomized trial. HOPE Investigators. BMJ 2002;324:15.Google Scholar
van Gijn, J: The PROGRESS Trial: Preventing strokes by lowering blood pressure in patients with cerebral ischemia. Stroke 2002;33:319320.Google Scholar
Hankey, GJ: Angiotensin-converting enzyme inhibitors for stroke prevention. Is there HOPE for PROGRESS after LIFE? Stroke 2003; 34:354356.Google Scholar
Chapman, N, Huxley, R, Anderson, C, et al: Effects of a perendopril-based blood pressure-lowering regimen on the risk of recurrent stroke according to stroke subtype and medical history. The PROGRESS Trial. Stroke 2004;35:116121.Google Scholar
Iadecola, C, Gorelick, PB: Hypertension, angiotensin, and stroke: Beyond blood pressure. Stroke 2004;35:348350.Google Scholar
Toole, FJ, Janeway, R, Choi, K, et al: Transient ischemic attacks due to atherosclerosis: A prospective study of 160 patients. Arch Neurol 1975;32:512.Google Scholar
Chimowitz, MI, Weiss, DG, Cohen, SL, et al: Veterans Affairs Cooperative Study Group 167. Cardiac prognosis of patients with carotid stenosis and no history of coronary artery disease. Stroke 1994;25:759765.Google Scholar
Chimowitz, MI: Asymptomatic coronary artery disease in patients with carotid artery stenosis: Incidence, prognosis, and treatment. In Caplan, LR, Hurst, JW, Chimowitz, M (eds): Clinical Neurocardiology. New York: Marcel Dekker, 1999, pp 287295.Google Scholar
Adams, R, Chimowitz, MI, Alpert, JS, et al. Coronary risk evaluation in patients with transient ischemic attack and ischemic stroke: a scientific statement for healthcare professionals from the Stroke Council and the Council on Clinical Cardiology of the American Heart Association/American Stroke Association. Stroke 2003;34:23102322.Google Scholar
DECODE Study Group, European Diabetes Epidemiology Group: Glucose tolerance and mortality: Comparison of WHO and American Diabetes Association diagnostic criteria. Lancet 1999;354:617621.Google Scholar
Grundy, SM, Brewer, B Jr, Cleeman, JI, et al: NHLBI/AHA Conference proceedings. Definition of metabolic syndrome. Circulation 2004;109:433438.Google Scholar
Grundy, S, Cleeman, JI, Daniels, SR, et al: Diagnosis and management of the metabolic syndrome. An American Heart Association/National Heart Lung, and Blood Institute Scientific Statement. Circulation 2005;112:27352752.Google Scholar
Bang, OY, Kim, JW, Lee, JH, et al: Association of the metabolic syndrome with intracranial atherosclerotic stroke. Neurology 2005;65:296298.Google Scholar
Mak, KH, Ma, S, Heng, D, et al: Impact of sex, metabolic syndrome, and diabetes mellitus on cardiovascular events. Am J Cardiol 2007;100:227233.Google Scholar
Arenillas, JF, Moro, MA, Dávalos, A: The metabolic syndrome and stroke: Potential treatment approaches. Stroke 2007;38:21962203.Google Scholar
Kurl, S, Laukkanen, JA, Niskanen, L, et al: Metabolic syndrome and the risk of stroke in middle-aged men. Stroke 2006;37:806811.Google Scholar
Boden-Albala, B, Sacco, RL, Lee, H-S, et al: Metabolic syndrome and ischemic stroke risk. Northern Manhattan Study. Stroke 2008;39:3035.Google Scholar
Li, W, Ma, D, Liu, M, et al: Association between metabolic syndrome and risk of stroke: A meta-analysis of cohort studies. Cerebrovasc Dis 2008;25:539547.Google Scholar
Mokdad, AH, Bowman, BA, Ford, ES, et al: The continuing epidemics of obesity and diabetes in the United States. JAMA 2001;286:11951200.Google Scholar
Jensen, MD, Ryan, DH, Apovian, CM, et al. 2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults. A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obsesity Society. J Am Coll Cardiol 2014;014;63(25_PA):doi:10.1016/j.jacc.2013.11.004.Google Scholar
Kurth, T, Gaziano, JM, Berger, K, et al: Body mass index and the risk of stroke in men. Arch Intern Med 2002;162:25572562.Google Scholar
Kurth, T, Gaziano, JM, Rexrode, KM, et al: Prospective study of body mass index and risk of stroke in apparently healthy women. Circulation 2005;111:19921998.Google Scholar
Hu, G, Tuomilehto, J, Silventoinen, K, et al: Body mass index, waist circumference, and waist–hip ratio on the risk of total and type-specific stroke. Arch Intern Med 2007;167:14201427.Google Scholar
Depres, J-P, Lemieux, I, Prud’homme, D: Treatment of obesity: Need to focus on high risk abdominally obese subjects. BMJ 2001;322:716720.Google Scholar
Fox, CS, Massaro, JM, Hoffmann, U, et al: Abdominal visceral and subcutaneous adipose tissue compartments: Association with metabolic risk factors in the Framingham Heart Study. Circulation 2007;116:3948.Google Scholar
Lear, SA, Humphries, KH, Kohli, S, et al: Visceral adipose tissue, a potential risk factor for carotid atherosclerosis. Results of the Multicultural Community Health Assessment Trial (M-CHAT). Stroke 2007;38:24222429.Google Scholar
Suk, SH, Sacco, RL, Boden-Albala, B, et al: Abdominal obesity and risk of ischemic stroke: The Northern Manhattan Stroke Study. Stroke 2003;34:15861592.Google Scholar
Ruderman, N, Chisholm, D, Pi-Sunyer, X, Schneider, S: The metabolically obese, normal weight individual revisited. Diabetes 1998;47:699713.Google Scholar
McLaughlin, T, Allison, G, Abbasi, F, et al: Prevalence of insulin resistance and associated cardiovascular risk factors among normal weight, overweight, and obese individuals. Metabolism 2004;53:495499.Google Scholar
Schoenberg, BS, Schoenberg, DG, Pritchard, DA, et al: Differential risk factors for completed stroke and transient ischemic attack (TIA): Study of vascular disease (hypertension, cardiac disease, peripheral vascular disease) and diabetes mellitus. Trans Am Neurol Assoc 1980;105:165167.Google Scholar
Burchfiel, CM, Curb, D, Rodriguez, B, et al: Glucose intolerance and 22-year stroke incidence. The Honolulu Heart Program. Stroke 1994;25:951957.Google Scholar
Jorgenson, H, Nakayama, H, Raaschou, HO, Olsen, TS: Stroke in patients with diabetes. The Copenhagen Stroke Study. Stroke 1994;25:19771984.Google Scholar
Karapanayiotides, TH, Piechowski-Jozwiak, B, van Melle, G, et al: Stroke patterns, etiology, and prognosis in patients with diabetes mellitus. Neurology 2004;62:15581562.Google Scholar
Fox, C, Coady, S, Sorlie, P, et al: Increased cardiovascular disease burden due to diabetes mellitus. The Framingham Heart Study. Circulation 2007;115:15441550.Google Scholar
Caplan, LR: Intracranial branch atheromatous disease: A neglected, understudied, and underused concept. Neurology 1989;39:12461250.Google Scholar
Caplan, LR: Diabetes and brain ischemia. Diabetes 1996;45(suppl 3):595597.Google Scholar
Depres, J-P, Golay, A, Sjostrom, L: Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. Rimonabant in Obesity–Lipids Study Group. N Engl J Med 353:21212134.Google Scholar
Higa, M, Davanipour, Z: Smoking and stroke. Neuroepidemiology 1991;10:211222.Google Scholar
Love, BB, Biller, J, Jones, MP, et al: Cigarette smoking: A risk factor for cerebral infarction in young adults. Arch Neurol 1990;47:693698.Google Scholar
Whisnant, JP, Homer, D, Ingall, TJ, et al: Duration of cigarette smoking is the strongest predictor of severe extracranial carotid artery atherosclerosis. Stroke 1990;21:707714.Google Scholar
Ingall, TJ, Homer, D, Baker, HL, et al: Predictors of intracranial carotid artery atherosclerosis: Duration of cigarette smoking and hypertension are more powerful than serum lipid levels. Arch Neurol 1991;48:687691.Google Scholar
Colditz, GA, Bonita, R, Stampfer, MJ, et al: Cigarette smoking and risk of stroke in middle-aged women. N Engl J Med 1988;318:937941.Google Scholar
Donnan, GA, You, R, Thrift, A, McNeil, JJ: Smoking as a risk factor for stroke. Cerebrovasc Dis 1993;3:129138.Google Scholar
Wolf, P, Kannel, WB, Verter, J: Current status of risk factors for stroke. In Barnett, HJM (ed): Neurologic Clinics, vol 1. Cerebrovascular Disease. Philadelphia: Saunders, 1983, pp 317343.Google Scholar
Paffenbarger, R, Williams, J: Chronic disease in former college students: V. Early precursors of fatal stroke. Am J Public Health 1967;57:12901299.Google Scholar
Kawachi, I, Colditz, GA: Smoking cessation and decreased risk of stroke in women. JAMA 1993;269:232236.Google Scholar
Jee, SH, Suh, I, Kim, IS, Appel, LJ: Smoking and atherosclerotic cardiovascular disease in men with low levels of serum cholesterol. JAMA 1999;282:21492155.Google Scholar
Kurth, T, Kase, CS, Berger, K, et al: Smoking and the risk of hemorrhagic stroke in men. Stroke 2003;34:11511155.Google Scholar
Collaborative Group for the Study of Stroke in Young Women: Oral contraceptives and stroke in young women: Associated risk factors. JAMA 1975;231:718722.Google Scholar
Fust, G, Arason, GJ, Kramer, J, et al: Genetic basis of tobacco smoking: Strong association of a specific major histocompatibility complex haplotype on chromosome 6 with smoking behavior. Int Immunol 2004;16:15071514.Google Scholar
Arason, GJ, Kramer, J, Blasko, B, et al: Smoking and a complement gene polymorphism interact in promoting cardiovascular disease morbidity and mortality. Clin Exp Immunol 2007;149:132138.Google Scholar
Gorelick, PB: Burden of stroke and risk factors. In Bornstein, NM (ed): Stroke. Basel: Karger, 2009, pp 923.Google Scholar
Tell, GS, Crouse, JR, Furberg, CD: Relation between blood lipids, lipoproteins, and cerebrovascular atherosclerosis. A review. Stroke 1988;19:423430.Google Scholar
Kurth, T, Everett, BM, Buring, JE, et al: Lipid levels and the risk of ischemic stroke in women. Neurology 2007;68:556562.Google Scholar
Bang, OY, Saver, JL, Liebeskind, DS, et al: Association of serum lipid indices with large artery atherosclerotic stroke. Neurology 2008;70:841847.CrossRefGoogle ScholarPubMed
Kannel, WB: Epidemiology of cerebrovascular disease. In Ross-Russel, RW (ed): Cerebral Arterial Disease. New York: Churchill Livingstone, 1976, pp 123.Google Scholar
Kagan, A, Popper, J, Rhoads, G: Factors related to stroke incidence in Hawaiian Japanese men: The Honolulu Heart Study. Stroke 1980;11:1421.Google Scholar
Stemmerman, G, Hayashi, T, Resch, J, et al: Risk factors related to ischemic and hemorrhagic cerebrovascular disease at autopsy: The Honolulu Heart Study. Stroke 1984;15:2328.Google Scholar
Iso, H, Jacobs, DR, Wentworth, D, et al: Serum cholesterol levels and six year mortality from stroke in 350,977 men screened for the Multiple Risk Factor Intervention Trial. N Engl J Med 1989;320:904910.Google Scholar
Yano, K, Reed, DM, Maclean, CJ: Serum cholesterol and hemorrhagic stroke in the Honolulu Heart Program. Stroke 1989;20:14601465.Google Scholar
Goldstein, LB, Amarenco, P, Szarak, M, et al: SPARCL Investigators. Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels study. Neurology 2008;70:2364–70.Google Scholar
Heart Protection Study Collaborative Group: MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: A randomized placebo-controlled trial. Lancet 2002;360:722.Google Scholar
Hackam, DG, Austin, PC, Huang, A, et al: Statins and intracerebral hemorrhage: A retrospective cohort study. Arch Neurol 2012;69:3945.Google Scholar
Nakamura, H, Arakawa, A, Itakura, H, et al: Primary prevention of cardiovascular events with pravastatin in Japanese (MEGA) study: A prospectively randomized controlled trial. Lancet 2006;30:11551163.Google Scholar
Kurth, T, Everett, BM, Buring, JE, et al: Lipid levels and the risk of ischemic stroke in women. Neurology 2007;68:556562.Google Scholar
Tanne, D, Yaari, S, Goldbourt, U: High-density lipoprotein cholesterol and risk of ischemic stroke mortality. A 21-year follow-up of 8586 men from Israeli Ischemic Heart Disease Study. Stroke 1997;28:8387.Google Scholar
Steinberg, D, Parthasarthy, S, Carcio, TE, et al: Beyond cholesterol: Modification of low-density lipoprotein that increases its atherogenicity. N Engl J Med 1989;320:915.Google Scholar
Scanu, A, Lawn, RM, Berg, K: Lipoprotein (a) and atherosclerosis. Ann Intern Med 1991;115:209218.Google Scholar
Pedro-Botet, J, Senti, M, Nogues, X, et al: Lipoprotein and apolipoprotein profile in men with ischemic stroke. Role of lipoprotein (a), triglyceride-rich lipoproteins, and apolipoprotein E polymorphism. Stroke 1992;23:15561562.Google Scholar
Wilt, TJ, Rubins, HB, Robins, SJ, et al: Carotid atherosclerosis in men with low levels of HDL cholesterol. Stroke 1997;28:19191925.Google Scholar
Homer, D, Ingall, TJ, Baber, HL, et al: Serum lipids and lipoproteins are less powerful predictors of extracranial carotid artery atherosclerosis than are cigarette smoking and hypertension. Mayo Clin Proc 1991;66:259267.CrossRefGoogle ScholarPubMed
Taylor, FC, Huffman, M, Ebrahim, S: Statin therapy for primary prevention of cardiovascular disease. JAMA 2013;310:24512452.Google Scholar
Bucher, HC, Griffith, LE, Guyatt, GH: Effect of HMGCoA reductase inhibitors on stroke. A meta-analysis of randomized controlled trials. Ann Intern Med 1998;128:8995.Google Scholar
Amarenco, P, Lavallee, P, Touboul, P-J: Stroke prevention, blood cholesterol, and statins. Lancet Neurol 2004;3:271278.Google Scholar
SPARCL Investigators: High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med 2006;355:549559.Google Scholar
Paciaroni, M, Hennerici, M, Agnelli, G, Bogousslavsky, J: Statins and stroke prevention. Cerebrovasc Dis 2007;24:170182.Google Scholar
Gorelick, PB: The status of alcohol as a risk factor for stroke. Stroke 1989;20:16071610.Google Scholar
Hillborn, M, Kaste, M: Alcohol intoxication: A risk factor for primary subarachnoid hemorrhage. Neurology 1982;32:706711.Google Scholar
Kagan, A, Yano, K, Rhoads, G, et al: Alcohol and cardiovascular disease: The Hawaiian experience. Circulation 1981;64(suppl 3):2731.Google Scholar
Bogousslausky, J, Van Melle, G, Despland, PA, Regli, F: Alcohol consumption and carotid atherosclerosis in the Lausanne stroke registry. Stroke 1990;21:715720.Google Scholar
Palomaki, H, Kaste, M: Regular light-to-moderate intake of alcohol and the risk of ischemic stroke. Stroke 1993;24:18281832.CrossRefGoogle ScholarPubMed
Kiechi, S, Willeit, J, Rungger, G, et al: Alcohol consumption and atherosclerosis: What is the relation. Prospective results from the Bruneck Study. Stroke 1998;29:900907.Google Scholar
Gorelick, PB, Rodin, MB, Langenberg, P, et al: Is acute alcohol ingestion a risk factor for ischemic stroke? Stroke 1987;18:359364.Google Scholar
Gorelick, PB, Rodin, MB, Langengerg, P, et al: Weekly alcohol consumption, cigarette smoking, and the risk of ischemic stroke. Neurology 1989;39:339343.Google Scholar
Truelsen, T, Gronbaek, M, Schnohr, P, Boysen, G: Intake of beer, wine, and spirits and risk of stroke. The Copenhagen Heart Study. Stroke 1998;29:24672472.Google Scholar
Hertog, MG, Feskens, EJ, Hollman, PC, et al: Dietary antioxidant flavonoids and risk of coronary heart disease. Lancet 1993;342:10071011.Google Scholar
Frankel, EN, Kanner, J, German, JB, et al: Inhibition of oxidation of human low-density lipoproteins by phenolic substances in red wine. Lancet 1993;341:454457.Google Scholar
Hillbom, M, Haapaniemi, H, Juvela, S, et al: Recent alcohol consumption, cigarette smoking, and cerebral infarction in young adults. Stroke 1995;26:4045.Google Scholar
Mostofsky, E, Burgern, MR, Schlaug, G, et al: Alcohol and acute ischemic stroke onset. The Stroke Onset Study. Stroke 2010;41:18451849.Google Scholar
Conen, D, Tedrow, UB, Cook, NR, et al: Alcohol consumption and risk of incident atrial fibrillation in women. JAMA 2008;300:24892496.Google Scholar
Sull, JW, Yi, S-W, Nam, CM, Ohrr, H: Binge drinking and mortality from all causes and cerebrovascular diseases in Korean men and women. A Kangwha cohort study. Stroke 2009;40:29532958.Google Scholar
Sundell, L, Salomaa, V, Vartiainen, E, et al: Increased stroke risk is related to a binge drinking habit. Stroke 2008;39:31793184.Google Scholar
Criqui, MH: Peripheral arterial disease and subsequent cardiovascular mortality: A strong and consistent association. Circulation 1990;82:22462247.Google Scholar
Criqui, MH, Langer, RD, Fronek, A, et al: Mortality over a period of 10 years in patients with peripheral arterial disease. N Engl J Med 1992;326:381386.Google Scholar
Bhatt, DL, Steg, PG, Ohman, EM, et al: International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis. REACH Registry Investigators. JAMA 2006;295:180189.Google Scholar
Bogousslavsky, J, Regli, F: Cerebral infarct in apparent transient ischemic attack. Neurology 1985;35:15011503.Google Scholar
Awad, I, Modic, M, Little, JR, et al: Focal parenchymal lesions in transient ischemic attacks: Correlation of computed tomography and magnetic resonance imaging. Stroke 1986;17:399403.Google Scholar
Caplan, LR: TIAs: We need to return to the question, “What is wrong with Mr Jones?” Neurology 1988;39:791793.Google Scholar
Fazekas, F, Fazekas, G, Schmidt, R, et al: Magnetic resonance imaging correlates of transient cerebral ischemic attacks. Stroke 1996;27:607611.Google Scholar
Inatomi, Y, Kimura, K, Yonehara, T, et al: DWI abnormalities and clinical characteristics in TIA patients. Neurology 2004;62:376380.Google Scholar
Dennis, MS, Bamford, JM, Sandercock, PA, Warlow, CD: A comparison of risk factors and prognosis for transient ischemic attacks and minor ischemic strokes. Stroke 1989;20:14941499.Google Scholar
Johnston, SC, Gress, DR, Browner, WS, Sidney, S: Short-term prognosis after emergency department diagnosis of TIA. JAMA 2000;284:29012906.Google Scholar
Daffertshofer, M, Mielke, O, Pullwitt, A, et al: Transient ischemic attacks are more than “ministrokes.” Stroke 2004;35:24532458.Google Scholar
Kleindorfer, D, Pangos, P, Pancoli, A, et al: Incidence and short-term prognosis of transient ischemic attack in a population-based study. Stroke 2005;36:720724.Google Scholar
Hill, MD, Yiannakoulias, N, Jeerakathil, T, et al: The high risk of stroke immediately after transient ischemic attack. A population-based study. Neurology 2004;62:20152020.Google Scholar
Rothwell, PM, Warlow, CP: Timing of TIAs preceding stroke. Time window for prevention is very short. Neurology 2005;64;817820.Google Scholar
Amarenco, P, Lavallée, P, Labreuche, J, et al: Contemporary profile and prognosis of transient ischemic attacks in the era of urgent management. N Engl J Med, 2016;in press.Google Scholar
Touze, E, Varenne, O, Chatellier, G, et al: Risk of myocardial infarction and vascular death after transient ischemic attack and ischemic stroke. Stroke 2005;36:27482755.Google Scholar
Nguyen-Huynh, MN, Johnston, SC: Transient ischemic attack: A neurologic emergency. Curr Neurol Neurosci Rep 2005;5:1320.Google Scholar
Ay, H, Koroshetz, WJ, Benner, T, et al: Transient ischemic attack with infarction: A unique syndrome. Ann Neurol 2005;57:679686.Google Scholar
Albers, GW, Caplan, LR, Easton, JD, et al., for the TIA Working Group: Transient ischemic attack: proposal for a new definition. N Engl J Med 2002;347:17131716.Google Scholar
Easton, JD, Saver, JL, Albers, GA, et al: Definition and evaluation of transient ischemic attack: A scientific statement for healthcare professionals from the American Heart Association/American Stroke Council, Council on Cardiovascular Surgery and Anesthesia, Council on Cardiovascular Radiology and Intervention, Council on Cardiovascular Nursing, and the Interdisciplinary Council on Peripheral Vascular Disease: The American Academy of Neurology affirms the value of this statement as an educational tool for neurologists. Stroke 2009;40:22762293.Google Scholar
Johnston, SC, Rothwell, PM, Nguyen-Huynh, MN, et al: Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack. Lancet 2007;369:283292.Google Scholar
Merwick, A, Albers, GW, Amarenco, P, et al: Addition of brain and carotid imaging to the ABCD2 score to identify patients at early risk of stroke after transient ischemic attack: a multicenter observational study. Lancet Neurol 2010;9:10601069.Google Scholar
Caplan, LR: Scores of scores. JAMA Neurol 2013;70:252253.Google Scholar
Amarenco, P, Labreuche, J, Lavallée, PC: Patients with transient ischemic attacks with ABCD2 ≤4 can have similar 90-day stroke risks as patients with transient ischemic attacks with ABCD2 ≥4. Stroke 2012;43:863865.Google Scholar
Lou, M, Safdar, A, Edlow, JA, et al: Can ABCD score predict the need for in-hospital intervention in patients with transient ischemic attacks? Int J Emerg Med 2010;3:7580.Google Scholar
Rothwell, PM, Giles, MF, Chandratheva, A, et al: for the Early Use of Existing Preventive Strategies for Stroke (EXPRESS) Study. Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS Study): A prospective population-based sequential comparison. Lancet 2007;370:14321442.Google Scholar
Collaborative Group for the Study of Stroke in Young Women: Oral contraception and increased risk of cerebral ischemia or thrombosis. N Engl J Med 1973;288:871878.Google Scholar
Handin, R: Thromboembolic complications of pregnancy and oral contraceptives. Prog Cardiovasc Dis 1974;16:395405.Google Scholar
Layde, P, Beral, V, Kay, C: Further analyses of mortality in oral contraceptive users. Lancet 1981;1:541546.Google Scholar
Bushnell, CD: Stroke and the female brain. Nat Clin Pract Neurol 2008;4:2233.Google Scholar
Lidegaard, O, Kreiner, S: Cerebral thrombosis and oral contraceptives: A case-control study. Contraception 1998;57:303314.Google Scholar
Schwartz, SM, Siscovick, DS, Longstreth, WT Jr, et al: Use of low-dose oral contraceptives and stroke in young women. Ann Intern Med 1997;127:596603.Google Scholar
Schwartz, SM, Petitti, DB, Siscovick, DS, et al: Stroke and use of low-dose oral contraceptives in young women. A pooled analysis of two US studies. Stroke 1998;29:22772284.Google Scholar
Siritho, S, Thrift, A, McNeil, JJ, et al: Risk of ischemic stroke among users of the oral contracveptive pill. The Melbourne Risk Factor Study (MERFS) Group. Stroke 2003;34:15751580.Google Scholar
Jick, SS, Jick, H: The contraceptive patch in relation to ischemic stroke and acute myocardial infarction. Pharmacotherapy 2007;27:218220.Google Scholar
Chasan-Taber, L, Stampfer, MJ: Epidemiology of oral contraceptives and cardiovascular disease. Ann Intern Med 1998;128:467477.Google Scholar
Martinelli, I, Sacchi, E, Landi, G, et al: High risk of cerebral-vein thrombosis in carriers of a prothrombin-gene mutation and in users of oral contraceptives. N Engl J Med 1998;338:17931797.Google Scholar
Lidegaard, O, Lokkegaard, E, Jensen, A, Skovlund, CW, Keiding, N: Thrombotic stroke and myocardial infarction with hormonal contraception. N Engl J Med 2012;366:22572266.Google Scholar
Qureshi, A, Giles, WH, Croft, JB, Stern, BJ: Number of pregnancies and risk for stroke and stroke subtypes. Arch Neurol 1997;54:203206.Google Scholar
Kittner, SJ, Stern, BJ, Feeser, BR, et al: Pregnancy and the risk of stroke. N Engl J Med 1996;335:768774.Google Scholar
Finucane, FF, Madans, JH, Bush, TL, et al: Decreased risk of stroke among postmenopausal hormone users. Arch Intern Med 1993;153:7379.Google Scholar
Grodstein, F, Manson, JE, Colditz, GA, et al: A prospective observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease. Ann Intern Med 2000;133:933941.Google Scholar
Lokkegaard, E, Jovanovic, Z, Heitemann, BL, et al: Increased risk of stroke in hypertensive women using hormone therapy. Analysis based on the Danish Nurse Study. Arch Neurol 2003;60:13791384.Google Scholar
Wilson, PW, Garrison, RJ, Castelli, WP: Postmenopausal estrogen use, cigarette smoking, and cardiovascular morbidity in women over 50. The Framingham Study. N Engl J Med 1985;313:10381043.Google Scholar
Simon, JA, Hsia, J, Cawley, JA, et al: Postmenopausal hormone therapy and risk of stroke. The Heart and Estrogen/Progestin Replacement Study (HERS). Circulation 2001;103:638642.Google Scholar
Grady, D, Harrington, D, Bittner, V, et al: For the HERS Research Group. Cardiovascular disease outcomes during 6–8 years of hormone therapy. The Heart and Estrogen/Progestin Replacement Study (HERS II). JAMA 2002;288:4957.Google Scholar
Viscoli, CM, Brass, LM, Kernan, WN, et al: A clinical trial of estrogen-replacement therapy after ischemic stroke. N Engl J Med 2001;345:12431249.Google Scholar
Rossouw, JE, Anderson, GL, Prentice, RL, et al: Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women’s Health Initiative randomized controlled trial. JAMA 2002;288:321333.Google Scholar
Wassertheil-Smoller, S, Hendrix, SL, Mimacher, M, et al: Effect of estrogen plus progestins on stroke in postmenopausal women. The Women’s Health Initiative: A randomized controlled trial. JAMA 2003;289:26732684.Google Scholar
The Women’s Health Initiative Steering Committee: Effects of conjugated equine estrogen in postmenopausal women with hysterectomy. The Women’s Health Initiative: A randomized controlled trial. JAMA 2004;291:17011712.Google Scholar
Nelson, H, Walker, M, Zakher, B, Mitchell, J: Menopausal hormone therapy for the primary prevention of chronic conditions: a systematic review to update the US Preventive Serices Task Force recommendations. Ann Intern Med 2012; 157: 104113.Google Scholar
Whitmer, RA, Quesenberry, CP, Zhou, J, Yaffe, K: Timing of hormone therapy and dementia: the critical window theory revisted. Ann Neurol 2011;69:163169.Google Scholar
The 2012 Hormone Therapy Position Statement of the North American Menopause Society. Menopause 2012;19:257271.Google Scholar
Moyer, VA, on behalf of the US Preventive Services Task Force: Menopausal hormone therapy for the primary prevention of chronic conditions: US Preventive Services Task Force recommendation statement. Ann Intern Med 2013;158:4754.Google Scholar
Espeland, MA, Shumaker, SA, Leng, I, et al: Long-term effects on cognitive function of postmenopausal hormone therapy presecribed to women aged 50 to 55 years. JAMA Intern Med 2013;173:14291236.Google Scholar
Wannamethee, G, Shaper, AG: Physical activity and stroke in middle-aged men. BMJ 1992;304:597601.Google Scholar
Sacco, RL, Gan, R, Boden-Albala, B, et al: Leisure-time physical activity and ischemic stroke risk. The Northern Manhattan Stroke Study. Stroke 1998;29:380387.Google Scholar
Lindenstrom, E, Boysen, G, Nyboe, J: Lifestyle factors and risk of cerebrovascular disease in women. The Copenhagen City Heart Study. Stroke 1993;24:14681472.Google Scholar
Agnarsson, U, Thorgeirsson, G, Sigvaldson, H, Sigfusson, N: Effects of leisure-time physical activity and ventilatory function on risk for stroke in men: The Reykjavik Study. Ann Intern Med 1999;130:987990.Google Scholar
Choi-Kwon, S, Kim, JS: Lifestyle factors and risk of stroke in Seoul, South Korea. J Stroke Cerebrovasc Dis 1998;7:414420.Google Scholar
Lee, I-M, Paffenbarger, RS Jr: Physical activity and stroke incidence. The Harvard Alumni Health Study. Stroke 1998;29:20492054.Google Scholar
Lee, I-M, Hennekens, CH, Berger, K, et al: Exercise and risk of stroke in male physicians. Stroke 1999;30:16.Google Scholar
Hu, FB, Stampfer, MJ, Colditz, G, et al: Physical activity and risk of stroke in women. JAMA 2000;283:29612967.Google Scholar
Lee, CD, Folsom, AR, Blair, SN: Physical activity and stroke risk. A meta-analysis. Stroke 2003;34:24752482.Google Scholar
Paffenbarger, RS Jr, Wing, AL, Hyde, RT, Jung, DL: Physical activity and incidence of hypertension in college alumni. Am J Epidemiol 1983;117:245257.Google Scholar
Paffenbarger, RS Jr, Jung, DL, Leung, RW, Hyde, RT: Physical activity and hypertension: An epidemiological view. Ann Med 1991;23:319327.Google Scholar
Hayashi, T, Tsumura, K, Suematsu, C, et al: Walking to work and the risk of hypertension in men: The Osaka Health Survey. Ann Intern Med 1999;130:2126.Google Scholar
Endres, M, Gertz, K, Lindauer, U, et al: Mechanisms of stroke protection by physical activity. Ann Neurol 2003;54:582590.Google Scholar
Eckel, RH, Jakicic, JM, Ard, JD, et al: 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk. Circulation 2014;129:S76S99.Google Scholar
Wing, S, Casper, M, Davis, WB, et al: Stroke mortality maps. Stroke 1988;19:15071513.Google Scholar
Lanska, DJ: Geographic distribution of stroke mortality in the United States: 1939–1941 to 1979–1981. Neurology 1993;43:18391851.Google Scholar
Lanska, DJ, Kryscio, R: Geographic distribution of hospitalization rates, case fatality, and mortality from stroke in the United States. Neurology 1994;44:15411550.Google Scholar
Glymour, WM, Avendano, M, Berkman, LF: Is the “stroke belt” worn from childhood? Risk of first stroke and state of residence in childhood and adulthood. Stroke 2007;38:24152421.Google Scholar
Howard, G, Prineas, R, Moy, C, et al: Racial and geographic differences in awareness, treatment, and control of hypertension: The Reasons for Geographic and Racial Differences in Stroke Study. Stroke 2006;37:11711178.Google Scholar
Vermeer, SE, Koudstaal, PJ, Oudkerk, M, et al: Prevalence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke 2002;33:2125.Google Scholar
Howard, G, Safford, MM, Meschia, JF, et al. Stroke symptoms in individuals reporting no prior stroke or transient ischemic attack are associated with decreased indices of mental and physical functioning. Stroke 2007; 38: 24462452.Google Scholar
Caplan, LR: Significance of unexpected (silent) brain infarcts. In Caplan, LR, Shifrin, EG, Nicolaides, AN, Moore, WS (eds): Cerebrovascular Ischaemia. Investigation and Management. London: Med-Orion, 1996, pp 423433.Google Scholar
Wardlaw, JM, Smith, EE, Biessels, GJ, et al: Neuroimaging standards for research into small vessel disease and its contribution to aging and neurodegeneration. Lancet Neurol 2013;12:822838.Google Scholar
Ward, NS, Brown, MM: Leukoaraiosis. In Donnan, G, Norrving, B, Bamford, J, Bogousslavsky, J (eds):Subcortical Stroke, 2nd ed. Oxford: Oxford University Press, 2002, pp 4766.Google Scholar
Caplan, LR, Schoene, WC: Clinical features of subcortical arteriosclerotic encephalopathy (Binswanger’s disease). Neurology 1978;28:12061215.Google Scholar
Caplan, LR: Binswanger’s disease – revisited. Neurology 1995;45:626633.Google Scholar
Babikian, V, Ropper, AH: Binswanger disease: A review. Stroke 1987;18:112.Google Scholar
Fisher, CM: Binswanger’s encephalopathy: A review. J Neurol 1989;236:6579.Google Scholar
Gray, F, Dubas, F, Roullet, E, Escourolle, R: Leukoencephalopathy in diffuse hemorrhagic cerebral amyloid angiopathy. Ann Neurol 1985;18:5459.Google Scholar
Dubas, F, Gray, F, Roullet, E, Escourolle, R: Leukoencephalopathies arteriopathiques. Rev Neurol 1985;141:93108.Google Scholar
Loes, D, Biller, J, Yuh, WT, et al: Leukoencephalopathy in cerebral amyloid angiopathy: MR imaging in four cases. AJNR Am J Neuroradiol 1990;11:485488.Google Scholar
Baudrimont, M, Dubas, F, Joutel, A, et al: Autosomal dominant leukoencephalopathy and subcortical ischemic stroke: A clinicopathological study. Stroke 1993;24:122125.Google Scholar
Davous, P: CADASIL: A review with proposed diagnostic criteria. Eur J Neurology 1998;5:219233.Google Scholar
Chabriat, H, Levy, C, Taillia, H, et al: Patterns of MRI lesions in CADACIL. Neurology 1998;51:452457.Google Scholar
Chen, YW, Gurol, ME, Rosand, J, et al: Progression of white matter lesions and hemorrhages in cerebral amyloid angiopathy. Neurology 2006;67:8387.Google Scholar
Imaizumi, T, Honma, T, Horita, Y, et al: Hematoma size in deep intracerebral hemorrhage and its correlation with dot-like hemosiderin spots on gradient echo T2*-weighted MRI. J Neuroimaging 2006;16:236242.Google Scholar
Imaizumi, T, Horita, Y, Hashimoto, Y, Niwa, J: Dotlike hemosiderin spots on T2*-weighted magnetic resonance imaging as a predictor of stroke recurrence: A prospective study. J Neurosurg 2004;101:915920.Google Scholar
Klein, I, Iung, B, Labreuche, J, et al. and the IMAGE Study Group: Cerebral microbleeds are frequent in infective endocarditis. Stroke 2009;40:34613465.Google Scholar
Hollenhorst, R: Ocular manifestations of insufficiency or thrombosis of the internal carotid artery. Am J Ophthalmol 1959;47:753767.Google Scholar
Fisher, CM: Observations of the fundus oculi in transient monocular blindness. Neurology 1959;9:333347.Google Scholar
Kearns, T, Hollenhorst, R: Venous stasis retinopathy of occlusive disease of the carotid artery. Mayo Clin Proc 1963;38:304312.Google Scholar
Carter, JE: Chronic ocular ischemia and carotid vascular disease. In Bernstein, EF (ed): Amaurosis Fugax. New York: Springer, 1988, pp 118134.Google Scholar
Slaoui, T, Klein, IF, Guidoux, C, et al: Prevalence of subdiaphragmatic visceral infarction in cardioembolic stroke. Neurology 2010;74:10301032.Google Scholar
Chatzikonstantinou, A, Krissak, R, Fluchter, S, et al: CT angiography of the aorta is superior to transesophageal echocardiography for determining stroke subtypes in patients with cryptogenic ischemic stroke. Cerebrovasc Dis 2012;33:322328.Google Scholar
Nicolaides, AN: Asymptomatic carotid stenosis and the risk of stroke (the ACSRS Study): Identification of a high-risk group. In Caplan, LR, Shifrin, EG, Nicolaides, AN, Moore, WS (eds): Cerebrovascular Ischaemia: Investigation and Management. London: Med-Orion, 1996, pp 435441.Google Scholar
Wityk, RJ, Chang, H-M, Rosengart, A, et al: Proximal extracranial vertebral artery disease in the New England Medical Center Posterior Circulation Registry. Arch Neurol 1998;55:470478.Google Scholar
Caplan, LR: Posterior Circulation Disease: Clinical Findings, Diagnosis, and Management. Boston: Blackwell, 1996.Google Scholar
Toghi, H, Yamanouchi, H, Murakami, M, et al: Importance of the hematocrit as a risk factor in cerebral infarction. Stroke 1978;9:369374.Google Scholar
Harrison, MJG, Pollock, S, Thomas, D, et al: Hematocrit, hypertension, and smoking in patients with transient ischemic attack and in age and sex matched controls. J Neurol Neurosurg Psychiatry 1982;45:550551.Google Scholar
Di Mascio, R, Marchioli, R, Vitullo, F, Tognoni, G: A positive relation between high hemoglobin values and the risk of ischemic stroke. Progetto 3 A Investigators. Eur Neurol 1996;36:8588.Google Scholar
Harrison, MJG, Pollock, S, Kendall, B, et al: Effect of hematocrit on carotid stenosis and cerebral infarction. Lancet 1981;2:114115.Google Scholar
Thomas, DJ, Marshall, J, Ross-Russel, RW, et al: Effects of hematocrit on cerebral blood flow in man. Lancet 1977;2:940943.Google Scholar
Elkind, MS, Sciacca, RR, Boden-Albala, B, et al: Relative elevation in baseline leukocyte count predicts first cerebral infarction. Neurology 2005;64:21212125.Google Scholar
Mercuri, M, Bond, MG, Evans, G, et al: Leukocyte count and carotid atherosclerosis. Stroke 1991:22:134.Google Scholar
Elkind, MS, Cheng, I, Boden-Albala, B, et al: Elevated white blood cell count and carotid plaque thickness: The Northern Manhattan Stroke Study. Stroke 2001;32:842849.Google Scholar
Elkind, MS, Sciacca, R, Boden-Albala, B, et al: Leukocyte count is associated with aortic arch plaque thickness. Stroke 2002;33:25872592.Google Scholar
Ovbiagele, B, Lynn, MJ, Saver, JL, et al: Leukocyte count and vascular risk in symptomatic intracranial atherosclerosis. WASID Study Group. Cerebrovasc Dis 2007;24:283288.Google Scholar
Elkind, MS, Sciacca, RR, Boden-Albala, B, et al: Leukocyte count is associated with reduced endothelial reactivity. Atherosclerosis 2005;181:329338.Google Scholar
Elkind, MS: Inflammation, atherosclerosis, and stroke. Neurologist 2006;12:140148.Google Scholar
Elkind, MSV: Impact of innate inflammation in population studies. Ann NY Acad Sci 2010;1207:97106.Google Scholar
Eikelboom, JW, Hankey, GJ, Baker, RI, et al: C-reactive protein in ischemic stroke and its etiologic subtypes. J Stroke Cerebrovasc Dis 2003;12:7481.Google Scholar
Arenillas, JF, Alvarez-Sabin, J, Molina, CA, et al: C-reactive protein predicts further ischemic events in first-ever transient ischemic attack or stroke patients with intracranial large-artery occlusive disease. Stroke 2003;34:24632470.Google Scholar
Wakugawa, Y, Kiyohara, Y, Tanizaki, Y, et al: C-reactive protein and risk of first-ever ischemic and hemorrhagic stroke in general Japanese population. The Hisayama Study. Stroke 2006;37:2732.Google Scholar
Gorelick, PB: Lipoprotein-associated phospholipase A2 and risk of stroke. Am J Cardiol 2008;101(suppl):34F40F.Google Scholar
Wilhelmsen, L, Svarrdsudd, K, Korsan-Bengtsen, K, et al: Fibrinogen as a risk factor for stroke and myocardial infarction. N Engl J Med 1984;311:501505.Google Scholar
Drouet, L: Fibrinogen: A treatable risk factor. Cerebrovasc Dis 1996;6(suppl 1):26.Google Scholar
Kristensen, B, Malm, J, Nilsson, T, et al: Increased fibrinogen levels and acquired hypofibrinolysis in young adults with ischemic stroke. Stroke 1998;29:22612267.Google Scholar
Grotta, J, Ackerman, R, Correia, J, et al: Whole-blood viscosity parameters and cerebral blood flow. Stroke 1982;13:296298.Google Scholar
Graham, IM, Daly, LE, Refsum, HM, et al: Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMA 1997;277:17751781.Google Scholar
Welch, GN, Loscalzo, J: Homocysteine and atherothrombosis. N Engl J Med 1998;338:10421050.Google Scholar
Giles, WH, Croft, JB, Greenlund, KJ, et al: Total homocyst(e)ine concentration and the likelihood of nonfatal stroke. Results from the Third National Health and Nutrition Examination Survey, 1988–1994. Stroke 1998;29:24732477.Google Scholar
Sacco, RL, Ananad, K, Lee, H-S, et al: Homocysteine and the risk of ischemic stroke in a triethnic cohort. The Northern Manhattan Study. Stroke 2004;35:22632269.Google Scholar
Selhub, J, Jacques, PF, Bostom, AG, et al: Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. N Engl J Med 1995;332:286291.Google Scholar
Eikelboom, JW, Hankey, GJ, Ananad, S, et al: Association between high homocyst(e)ine and ischemic stroke due to large and small-artery disease but not other etiologic subtypes of ischemic stroke. Stroke 2000;31:10691075.Google Scholar
Toole, JF, Malinow, MR, Chambless, LE, et al: Lowering homocysteine in patients with ischemic stroke to reduce recurrent stroke, myocardial infarction and death. The Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial JAMA 2004;291:565575.Google Scholar
VITATOPS Trial Study Group. B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: A randomised, double-blind, parallel, placebo-controlled trial. Lancet Neurol 2010;9:855865.Google Scholar
Beamer, NB, Coull, BM, Clark, WM, Wynn, M: Microalbuminuria in ischemic stroke. Arch Neurol 1999;56:699702.Google Scholar
Gaede, P, Vedel, P, Parving, H-H, Pederson, O: Intensified multifactorial intervention in patients with type 2 diabetes mellitus and micro-albuminuria: The Steno type 2 randomized study. Lancet 1999;353:617622.Google Scholar
Gerstein, H, Mann, JFE, Yi, Q, et al: F Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. HOPE Study Investigators. JAMA 2001;286:421426.Google Scholar
Ovbiagele, B: Impairment in glomerular filtration rate or glomerular filtration barrier and occurrence of stroke. Arch Neurol 2008;65:934938.Google Scholar
Khatri, M, Wright, CB, Nickolas, TL, et al: Chronic kidney disease is associated with white matter hyperintensity volume. The Northern Manhattan Study (NOMAS). Stroke 2007;38:31213126.Google Scholar
Alberts, MJ: Genetics of Cerebrovascular Disease. Armonk, NY: Futura, 1999.Google Scholar
Meschia, JF, Worrall, BB: New advances in identifying genetic anomalies in stroke-prone probands. Curr Neurol Neurosci Rep 2004;4:420426.Google Scholar
Gretarsdottir, S, Thorleifsson, G, Reynisdottir, ST, et al: The gene encoding phosphodiesterase 4D confers risk of ischemic stroke. Nat Genet 2003;35:131138.Google Scholar
Yee, RYL, Brophy, VH, Cheng, S, et al: Polymorphisms of the phosphodiesterase 4D, camp-specific (PDE4D) gene and risk of ischemic stroke. A prospective, nested case-control evaluation. Stroke 2006;37:20122017.Google Scholar
Worrall, BB, Mychaleckyj, JC: PDE4D and stroke. A real advance or a case of the emperor’s new clothes? Stroke 2006;37:19551957.Google Scholar
Ruigrok, YM, Rinkel, GJE, Wijmenga, C: Genetics of intracranial aneurysms. Lancet Neurol 2005;4:179189.Google Scholar
Ruigrok, YM, Rinkel, GJ, Wijmenga, C: The versican gene and the risk of intracranial aneurysms. Stroke 2006;37:23722374.Google Scholar
Markus, H: Stroke genetics: prospects for personalized medicine. BMC Med 2012;10:113, accessed at http://www.biomedcentral.com/1741-7015/10/113.Google Scholar
Wolf, PA, D’Agostino, RB, Belanger, AJ, Kannel, WB: Probability of stroke: A risk profile from the Framingham Study. Stroke 1991;22:312318.Google Scholar
Wolf, PA, Belanger, AJ, D’Agostino, RB: Quantifying stroke risk factors and potentials for risk reduction. Cerebrovasc Dis 1993;3(suppl 1):714.Google Scholar
Goff, DC, Lloyd-Jones, DM, Bennet, G, et al: 2013 ACC/AHA guideline on the assessment of cardiovascular risk: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2014;63:29352959.Google Scholar
Stone, NJ, Robinson, JG, Lichtenstein, AH, et al: 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2014;63:28892934.Google Scholar
James, PA, Oparil, S, Carter, BL, et al: 2014 evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eight Joint National Committee (JNC 8). JAMA 2014;311:507520, erratum 7;311:1809.Google Scholar
Banach, M, Aronow, WS: Blood pressure J-curve: Current concepts. Curr Hypertens Rep 2012;14:556566.Google Scholar
Meschia, JF, Bushnell, C, Bodsen-Albala, B, et al. on behalf of the American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, Council on Functional Genomics and Translational Biology, and Council on Hypertension: Guidelines for the primary prevention of stroke. A statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2014;45:37543832.Google Scholar
Yamamoto, H, Bogousslavsky, J: Mechanisms of second and further strokes. J Neurol Neurosurg Psychiatry 1998;64:771776.Google Scholar
Caplan, LR: Editorial. J Neurol Neurosurg Psychiatry 1998;64:716.Google Scholar
Inzitari, D, Eliasziw, M, Gates, P, et al: The causes and risk of stroke in patients with asymptomatic internal-carotid-artery stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med 2000;342:16931700.Google Scholar
Leonberg, SC, Elliot, FA: Prevention of recurrent stroke. Stroke 1981;12:731735.Google Scholar
Ovbiagele, B, Saver, JL, Fredieu, A, et al: In-hospital initiation of secondary stroke prevention therapies yields high rates of adherence at follow-up. Stroke 2004;35:28792883.Google Scholar
Touze, E, Coste, J, Voicu, M, et al: Importance of in-hospital initiation of therapies and therapeutic inertia in secondary stroke prevention. Implemetation of prevention after a cerebrovascular event (IMPACT) study. Stroke 2008;39:18341843.Google Scholar

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