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5.3 - Sex and Sex Hormones

from 5 - Neural Circuits

Published online by Cambridge University Press:  08 November 2023

Mary-Ellen Lynall
Affiliation:
University of Cambridge
Peter B. Jones
Affiliation:
University of Cambridge
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

Sex and gender are of increasing interest and importance in clinical medicine, and psychiatry in particular. A large body of scientific evidence from animal and human studies demonstrates widespread sex differences in neurochemistry, connectivity and structure in virtually all brain regions with consequences for emotional and behavioural regulation [1–3]. We also understand that mental illness is associated with changes in the structure, neurochemistry and function of the brain, which will be superimposed on the innate brain sex differences. These biological differences are thought to contribute to differences between men and women in the prevalence, age at onset, symptomatology, progression, pathology and therapeutic responsiveness manifest in neuropsychiatric, neurological and neurodegenerative disorders [1, 2, 4] (Table 5.3.1). A better understanding of brain sex differences will be critical to advancing our understanding of mental disorders in both sexes, enabling the development of different and improved preventive, diagnostic and treatment approaches that benefit both men and women.

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Publisher: Cambridge University Press
Print publication year: 2023

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References

Cahill, L.. Why sex matters for neuroscience. Nat Rev Neurosci 2006; 7:477484.CrossRefGoogle ScholarPubMed
Cosgrove, K. P., Mazure, C. M., Staley, J. K.. Biol Psychiatry 2007; 62: 847855.CrossRefGoogle Scholar
Gillies, G. E., McArthur, S.. Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines. Pharmacol Rev 2010; 62: 155198.CrossRefGoogle ScholarPubMed
Rubinow, D. R., Schmidt, P. J.. Sex differences and the neurobiology of affective disorders. Neuropsychopharmacology 2019; 44: 111128.CrossRefGoogle ScholarPubMed
McCarthy, M. M., Arnold, A. P.. Reframing sexual differentiation of the brain. Nature Neuroscience 2011; 14: 677683.CrossRefGoogle ScholarPubMed
De Vries, G. J.. Minireview: sex differences in adult and developing brains: compensation, compensation, compensation. Endocrinology 2004; 145: 1063–1068.CrossRefGoogle ScholarPubMed
Gillies, G. E., Virdee, K., McArthur, S. et al. Sex-dependent diversity in ventral tegmental dopaminergic neurons and developmental programming: A molecular, cellular and behavioral analysis. Neuroscience 2014; 282: 6985.CrossRefGoogle ScholarPubMed
Gillies, G. E., Pienaar, I. S., Vohra, S. et al. Sex differences in Parkinson’s disease. Front Neuroendocrinol 2014; 35: 370384.CrossRefGoogle ScholarPubMed
Gillies, G. E., Virdee, K., Pienaar, I. et al. Enduring, sexually dimorphic impact of in utero exposure to elevated levels of glucocorticoids on midbrain dopaminergic populations. Brain Sci 2016; 7(1): 5.CrossRefGoogle ScholarPubMed
Melcangi, R. C., Giatti, S., Garcia-Segura, L. M.. Levels and actions of neuroactive steroids in the nervous system under physiological and pathological conditions: sex-specific features. Neurosci Biobehav Rev 2016; 67: 2540.CrossRefGoogle ScholarPubMed
Paus, T., Keshavan, M., Giedd, J. N.. Why do many psychiatric disorders emerge during adolescence? Nat Rev Neurosci 2008; 9: 947957.CrossRefGoogle ScholarPubMed
Altemus, M.. Hormone-specific psychiatric disorders: do they exist? Arch Womens Ment Health 2010; 13: 2526.CrossRefGoogle ScholarPubMed
Toffoletto, S., Lanzenberger, R., Gingnell, M. et al. Emotional and cognitive functional imaging of estrogen and progesterone effects in the female human brain: a systematic review. Psychoneuroendocrinology 2014; 50: 2852.CrossRefGoogle ScholarPubMed
Riecher-Rössler, A.. Oestrogens, prolactin, hypothalamic–pituitary–gonadal axis, and schizophrenic psychoses. Lancet Psychiatry 2017; 4: 6372.CrossRefGoogle ScholarPubMed
Pike, C. J.. Sex and the development of Alzheimer’s disease. J Neurosci Res 2017; 95: 671680.CrossRefGoogle ScholarPubMed
Huang, Y. C., Hung, C. F., Lin, P. Y. et al. Gender differences in susceptibility to schizophrenia: potential implication of neurosteroids. Psychoneuroendocrinology 2017; 84: 8793.CrossRefGoogle ScholarPubMed
Wichmann, S., Kirschbaum, C., Böhme, C. et al. Cortisol stress response in post-traumatic stress disorder, panic disorder, and major depressive disorder patients. Psychoneuroendocrinology 2017; 83: 135141.CrossRefGoogle ScholarPubMed
Hoffman, A. N., Taylor, A. N.. Stress reactivity after traumatic brain injury: implications for comorbid post-traumatic stress disorder. Behav Pharmaco 2019; 30: 115121.CrossRefGoogle ScholarPubMed
Kudielka, B. M., Kirschbaum, C.. Sex differences in HPA axis responses to stress: a review. Biol Psychol 2005; 69: 113132.CrossRefGoogle ScholarPubMed
Bangasser, D. A., Wicks, B. J.. Sex-specific mechanisms for responding to stress. Neurosci Res 2017; 95: 7582.CrossRefGoogle ScholarPubMed
Maeng, L. Y., Milad, M. R.. Sex differences in anxiety disorders: interactions between fear, stress, and gonadal hormones. Horm Behav 2015; 76: 106117.CrossRefGoogle ScholarPubMed
Li, S. H., Graham, B. M.. Why are women so vulnerable to anxiety, trauma-related and stress-related disorders? The potential role of sex hormones. Lancet Psychiatry 2017; 4: 7382.CrossRefGoogle ScholarPubMed
Bäckström, T., Bixo, M., Johansson, M. et al. Allopregnanolone and mood disorders. Prog Neurobiol 2014; 113: 8894.CrossRefGoogle ScholarPubMed
Gifford, R. M., Reynolds, R. M.. Sex differences in early-life programming of the hypothalamic–pituitary–adrenal axis in humans. Early Hum Dev 2017; 114: 710.CrossRefGoogle ScholarPubMed
Heim, C., Binder, E. B.. Current research trends in early life stress and depression: review of human studies on sensitive periods, gene–environment interactions, and epigenetics. Exp Neurol 2012; 233: 102111.CrossRefGoogle ScholarPubMed
Roh, J. W., Park, H. J., Kang, U.. Hormones and psychiatric disorders. Clinic Psychopharmacol Neurosci 2007; 5: 313.Google Scholar
Chávez-Castillo, M., Núñez, V., Nava, M. et al. Depression as a neuroendocrine disorder: emerging neuropsychopharmacological approaches beyond monoamines. Adv Pharmacol Sci 2019; 2: 7943481.Google Scholar
Ritsner, M. S.. The clinical and therapeutic potentials of dehydroepiandrosterone and pregnenolone in schizophrenia. Neuroscience. 2011; 191: 91100.CrossRefGoogle ScholarPubMed
Irwin, R. W., Solinsky, C. M., Brinton, R. D.. Frontiers in therapeutic development of allopregnanolone for Alzheimer’s disease and other neurological disorders. Front Cell Neurosci 2014; 8: 203.CrossRefGoogle ScholarPubMed
Howard, L. M., Ehrlich, A. M., Gamlen F, F. et al. Gender-neutral mental health research is sex and gender biased. Lancet Psychiatry 2017; 4: 911.CrossRefGoogle ScholarPubMed
Solomon, M. B., Herman, J. P.. Sex differences in psychopathology: of gonads, adrenals and mental illness. Physiol Behav 2009; 97: 250258.CrossRefGoogle ScholarPubMed
Singh, M., Simpkins, J. W., Bimonte-Nelson, H. A. et al. Window of opportunity for estrogen and progestin intervention in brain aging and Alzheimer’s disease. Brain Res 2013; 1514: 12.CrossRefGoogle ScholarPubMed
Palacios, J., Yildiz, A., Young, A. H. et al. Tamoxifen for bipolar disorder: systematic review and meta-analysis. J Psychopharmacol 2019; 33: 177184.CrossRefGoogle ScholarPubMed
Pinna, G., Costa, E., Guidotti, A.. SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake. Curr Opin Pharmacol 2009; 9: 2430.CrossRefGoogle Scholar
McArthur, S., Siddique, Z. L., Christian, H. C. et al. Perinatal glucocorticoid treatment disrupts the hypothalamo-lactotroph axis in adult female, but not male, rats. Endocrinology 2006; 147: 19041915.CrossRefGoogle Scholar
Barata, BC. Affective disorders and sexual function: from neuroscience to clinic. Curr Opin Psychiatry 2017; 30: 396401.CrossRefGoogle ScholarPubMed
Kravvariti, V., Gonidakis, F. . [Eating disorders and sexual function]. Psychiatriki 2016; 27: 136143.CrossRefGoogle ScholarPubMed
Kopeykina, I., Kim, H. J., Khatun, T. et al. Hypersexuality and couple relationships in bipolar disorder: a review. J Affect Disord 2016; 195: 114.CrossRefGoogle ScholarPubMed
de Boer, M. K., Castelein, S., Wiersma, D. et al. The facts about sexual (dys)function in schizophrenia: an overview of clinically relevant findings. Schizophr Bull 2015; 41: 674686.CrossRefGoogle ScholarPubMed
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th ed. (DSM-5). American Psychiatric Association, 2013.Google Scholar
Nguyen, H. B., Loughead, J., Lipner, E. et al. What has sex got to do with it? The role of hormones in the transgender brain. Neuropsychopharmacology 2019; 44: 2237.CrossRefGoogle Scholar

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