Book contents
- Frontmatter
- Contents
- List of contributors
- Preface
- Psychology, health and illness
- Medical topics
- Abortion
- Accidents and unintentional injuries
- Acne
- Alcohol abuse
- Allergies to drugs
- Allergies to food
- Allergies: general
- Amnesia
- Amputation and phantom limb pain
- Anaesthesia and psychology
- Antenatal care
- Aphasia recovery, treatment and psychosocial adjustment
- Asthma
- Back pain
- Blindness and visual disability
- Blood donation
- Breastfeeding
- Burn injuries: psychological and social aspects
- Cancer: breast
- Cancers of the digestive tract
- Cancer: general
- Cancer: gynaecologic
- Cancer: head and neck
- Cancer: Hodgkin's and non-Hodgkin's lymphoma
- Cancer: leukaemia
- Cancer: lung
- Cancer: prostate
- Cancer: skin
- Carotid artery disease and treatment
- Chemotherapy
- Child abuse and neglect
- Chromosomal abnormalities
- Chronic fatigue syndrome
- Chronic obstructive pulmonary disease (COPD): chronic bronchitis and emphysema
- Cleft lip and palate
- Cold, common
- Complementary medicine
- Contraception
- Coronary heart disease: impact
- Coronary heart disease: cardiac psychology
- Coronary heart disease: heart failure
- Coronary heart disease: rehabilitation
- Coronary heart disease: surgery
- Cystic fibrosis
- Acquired hearing loss
- Dementias
- Diabetes mellitus
- Domestic violence, intimate partner violence and wife battering
- Drug dependency: benzodiazepines
- Drug dependence: opiates and stimulants
- Drugs: beta-blockers
- Drugs: psychotropic medication
- Dyslexia
- Eating disorders
- Eczema
- Endocrine disorders
- Enuresis
- Epilepsy
- Epstein–Barr virus infection
- Facial disfigurement and dysmorphology
- Fetal wellbeing: monitoring and assessment
- Gastric and duodenal ulcers
- Growth retardation
- Haemophilia
- Head injury
- Headache and migraine
- Herpes
- HIV/AIDS
- Hormone replacement therapy
- Hospital acquired infection
- Huntington's disease
- Hyperactivity
- Hypertension
- Hyperthyroidism
- Hyperventilation
- Hysterectomy
- Immunization
- Incontinence
- Infertility
- Inflammatory bowel disease
- Intensive care unit
- Intimate examinations
- Irritable bowel syndrome
- Lymphoedema
- Malaria
- Mastalgia (breast pain)
- Meningitis
- Menopause and postmenopause
- MMR vaccine
- Motor neurone disease
- Multiple sclerosis
- Myasthenia gravis
- Neurofibromatosis
- Non-cardiac chest pain
- Obesity
- Oral care and hygiene
- Osteoarthritis
- Osteoporosis
- Parkinson's disease
- Pelvic pain
- Post-traumatic stress disorder
- Postnatal depression
- Pregnancy and childbirth
- Premature babies
- Premenstrual syndrome
- Psoriasis
- Radiotherapy
- Rape and sexual assault
- Reconstructive and cosmetic surgery
- Renal failure, dialysis and transplantation
- Repetitive strain injury
- Rheumatoid arthritis
- Road traffic accidents: human factors
- Screening: antenatal
- Screening: cancer
- Screening: cardiac
- Screening: genetic
- Self-examination: breasts, testicles
- Sexual dysfunction
- Sexually transmitted infections
- Sickle cell disease
- Skin disorders
- Sleep apnoea
- Sleep disorders
- Spina bifida
- Spinal cord injury
- Sterilization and vasectomy
- Stroke
- Stuttering
- Suicide
- Tinnitus
- Tobacco use
- Toxins: environmental
- Transplantation
- Urinary tract symptoms
- Vertigo and dizziness
- Vision disorders
- Voice disorders
- Volatile substance abuse
- Vomiting and nausea
- Index
- References
Motor neurone disease
from Medical topics
Published online by Cambridge University Press: 18 December 2014
- Frontmatter
- Contents
- List of contributors
- Preface
- Psychology, health and illness
- Medical topics
- Abortion
- Accidents and unintentional injuries
- Acne
- Alcohol abuse
- Allergies to drugs
- Allergies to food
- Allergies: general
- Amnesia
- Amputation and phantom limb pain
- Anaesthesia and psychology
- Antenatal care
- Aphasia recovery, treatment and psychosocial adjustment
- Asthma
- Back pain
- Blindness and visual disability
- Blood donation
- Breastfeeding
- Burn injuries: psychological and social aspects
- Cancer: breast
- Cancers of the digestive tract
- Cancer: general
- Cancer: gynaecologic
- Cancer: head and neck
- Cancer: Hodgkin's and non-Hodgkin's lymphoma
- Cancer: leukaemia
- Cancer: lung
- Cancer: prostate
- Cancer: skin
- Carotid artery disease and treatment
- Chemotherapy
- Child abuse and neglect
- Chromosomal abnormalities
- Chronic fatigue syndrome
- Chronic obstructive pulmonary disease (COPD): chronic bronchitis and emphysema
- Cleft lip and palate
- Cold, common
- Complementary medicine
- Contraception
- Coronary heart disease: impact
- Coronary heart disease: cardiac psychology
- Coronary heart disease: heart failure
- Coronary heart disease: rehabilitation
- Coronary heart disease: surgery
- Cystic fibrosis
- Acquired hearing loss
- Dementias
- Diabetes mellitus
- Domestic violence, intimate partner violence and wife battering
- Drug dependency: benzodiazepines
- Drug dependence: opiates and stimulants
- Drugs: beta-blockers
- Drugs: psychotropic medication
- Dyslexia
- Eating disorders
- Eczema
- Endocrine disorders
- Enuresis
- Epilepsy
- Epstein–Barr virus infection
- Facial disfigurement and dysmorphology
- Fetal wellbeing: monitoring and assessment
- Gastric and duodenal ulcers
- Growth retardation
- Haemophilia
- Head injury
- Headache and migraine
- Herpes
- HIV/AIDS
- Hormone replacement therapy
- Hospital acquired infection
- Huntington's disease
- Hyperactivity
- Hypertension
- Hyperthyroidism
- Hyperventilation
- Hysterectomy
- Immunization
- Incontinence
- Infertility
- Inflammatory bowel disease
- Intensive care unit
- Intimate examinations
- Irritable bowel syndrome
- Lymphoedema
- Malaria
- Mastalgia (breast pain)
- Meningitis
- Menopause and postmenopause
- MMR vaccine
- Motor neurone disease
- Multiple sclerosis
- Myasthenia gravis
- Neurofibromatosis
- Non-cardiac chest pain
- Obesity
- Oral care and hygiene
- Osteoarthritis
- Osteoporosis
- Parkinson's disease
- Pelvic pain
- Post-traumatic stress disorder
- Postnatal depression
- Pregnancy and childbirth
- Premature babies
- Premenstrual syndrome
- Psoriasis
- Radiotherapy
- Rape and sexual assault
- Reconstructive and cosmetic surgery
- Renal failure, dialysis and transplantation
- Repetitive strain injury
- Rheumatoid arthritis
- Road traffic accidents: human factors
- Screening: antenatal
- Screening: cancer
- Screening: cardiac
- Screening: genetic
- Self-examination: breasts, testicles
- Sexual dysfunction
- Sexually transmitted infections
- Sickle cell disease
- Skin disorders
- Sleep apnoea
- Sleep disorders
- Spina bifida
- Spinal cord injury
- Sterilization and vasectomy
- Stroke
- Stuttering
- Suicide
- Tinnitus
- Tobacco use
- Toxins: environmental
- Transplantation
- Urinary tract symptoms
- Vertigo and dizziness
- Vision disorders
- Voice disorders
- Volatile substance abuse
- Vomiting and nausea
- Index
- References
Summary
Introduction
Motor Neurone Disease (MND), is a terminal, progressive neurodegenerative disease of the central nervous system. The most common form of MND is amyotrophic lateral sclerosis (ALS) involving both upper and lower motor neurones (UMNs, LMNs). Less common are primary lateral sclerosis (involving only UMNs) progressive muscular atrophy (involving only LMNs) and progressive bulbar palsy (PBP) where there is predominant involvement of the motor systems of the brainstem (Leigh & Ray-Chaudhuri, 1994). Peak age at onset is in the sixth decade of life. Incidence is around 1–2: 100 000 per year and prevalence 5–6:100 000. Median survival in ALS is 3.5 years from diagnosis, death commonly resulting from respiratory failure. Disease progression is generally variable but prognosis is poorest in those presenting with bulbar signs (about 25% of cases). Typically the disease presents with limb muscle weakness. Overall 90–95% of cases are sporadic, but 5–10% are familial in nature. At present there is no cure for MND. However the glutamate release antagonist, riluzole, has been shown to improve survival at 18 months (Lacomblez et al., 1996).
Psychological research concerning people with MND has predominantly involved investigations of the neuropsychological profile associated with ALS and of emotional and psychosocial issues (Goldstein & Leigh, 1999).
Neuropsychological aspects of MND
Increasing evidence that MND involves extra-motor cerebral regions is provided by findings of mild cognitive impairment occurring in up to 35–40% of non-demented patients with ALS, and by reports that a fronto-temporal dementia may also be seen in ~5% of sporadic cases (see ‘Dementias’).
- Type
- Chapter
- Information
- Cambridge Handbook of Psychology, Health and Medicine , pp. 784 - 786Publisher: Cambridge University PressPrint publication year: 2007
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