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37 - Transplantation of ovarian tissue or immature oocytes to preserve and restore fertility in humans

from Section 6 - Technology and clinical medicine

Published online by Cambridge University Press:  05 October 2013

By
Sherman Silber ,
Natalie Barbey  and
David Silber
Edited by
Alan Trounson ,
Roger Gosden  and
Ursula Eichenlaub-Ritter
Sherman Silber
Affiliation:
Infertility Center of St. Louis, St. Luke’s Hospital, St. Louis, MO, USA and University of Amsterdam, Department of Obstetrics and Gynecology, Reproductive Endocrinology, Amsterdam, Netherlands
Natalie Barbey
Affiliation:
Infertility Center of St. Louis, St. Luke’s Hospital, St. Louis, MO, USA
David Silber
Affiliation:
Infertility Center of St. Louis, St. Luke’s Hospital, St. Louis, MO, USA
Alan Trounson
Affiliation:
California Institute for Regenerative Medicine
Roger Gosden
Affiliation:
Center for Reproductive Medicine and Infertility, Cornell University, New York
Ursula Eichenlaub-Ritter
Affiliation:
Universität Bielefeld, Germany
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Summary

Introduction

It is now possible to preserve and restore fertility, using ovary and egg freezing and ovary transplantation, in young women with cancer who are undergoing otherwise sterilizing chemotherapy and radiation. This approach can also be used for any woman who wishes to prolong her reproductive lifespan. This chapter is limited to the clinically proven therapeutic applications of this technology. Our clinical results with these new therapeutic approaches are adding to our understanding of the basic science of reproduction, and may eventually obviate the growing worldwide epidemic of female age-related decline in fertility.

The developed world is in the midst of a widespread infertility epidemic. Economies in Japan, the United States, southern Europe, and even China are threatened by a decreasing population of young people having to support an increasing population of elderly and retirees [1]. The most common reason to see a doctor in countries such as India and China, seemingly plagued with overpopulation, is for infertility. Infertility clinics are popping up throughout the world in huge numbers [2].

Type
Chapter
Information
Biology and Pathology of the Oocyte
Role in Fertility, Medicine and Nuclear Reprograming
 , pp. 430 - 442
Publisher: Cambridge University Press
Print publication year: 2013

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