Book contents
- Frontmatter
- Contents
- Contributors
- Part I General Principles of Cell Death
- 1 Human Caspases – Apoptosis and Inflammation Signaling Proteases
- 2 Inhibitor of Apoptosis Proteins
- 3 Death Domain–Containing Receptors – Decisions between Suicide and Fire
- 4 Mitochondria and Cell Death
- 5 The Control of Mitochondrial Apoptosis by the BCL-2 Family
- 6 Endoplasmic Reticulum Stress Response in Cell Death and Cell Survival
- 7 Autophagy – The Liaison between the Lysosomal System and Cell Death
- 8 Cell Death in Response to Genotoxic Stress and DNA Damage
- 9 Ceramide and Lipid Mediators in Apoptosis
- 10 Cytotoxic Granules House Potent Proapoptotic Toxins Critical for Antiviral Responses and Immune Homeostasis
- Part II Cell Death in Tissues and Organs
- Part III Cell Death in Nonmammalian Organisms
- Plate section
- References
2 - Inhibitor of Apoptosis Proteins
from Part I - General Principles of Cell Death
Published online by Cambridge University Press: 07 September 2011
- Frontmatter
- Contents
- Contributors
- Part I General Principles of Cell Death
- 1 Human Caspases – Apoptosis and Inflammation Signaling Proteases
- 2 Inhibitor of Apoptosis Proteins
- 3 Death Domain–Containing Receptors – Decisions between Suicide and Fire
- 4 Mitochondria and Cell Death
- 5 The Control of Mitochondrial Apoptosis by the BCL-2 Family
- 6 Endoplasmic Reticulum Stress Response in Cell Death and Cell Survival
- 7 Autophagy – The Liaison between the Lysosomal System and Cell Death
- 8 Cell Death in Response to Genotoxic Stress and DNA Damage
- 9 Ceramide and Lipid Mediators in Apoptosis
- 10 Cytotoxic Granules House Potent Proapoptotic Toxins Critical for Antiviral Responses and Immune Homeostasis
- Part II Cell Death in Tissues and Organs
- Part III Cell Death in Nonmammalian Organisms
- Plate section
- References
Summary
Inhibitor of apoptosis proteins (IAPs) constitute a family of apoptosis-suppressing proteins that contain at least one copy of a conserved domain called baculoviral IAP repeat (BIR), a zinc-binding fold involved in protein interactions. Humans and other mammals contain multiple genes encoding IAP family members, providing a diversity of variants with both common and specialized functions. IAPs are known for their ability to bind certain caspases, which are proteases responsible for apoptosis. Several IAPs contain RING (really interesting new gene) domains that bind ubiquitin-conjugating enzymes (UBC), whereas others possess UBC catalytic domains. These attributes endow many IAPs with E3 ligase activity, implicating them in the ubiquitinylation and proteasome-dependent degradation of a variety of cellular substrates. In addition, several IAP family members have multifaceted functions as platforms for coordinating signal transduction events associated with activation of particular protein kinases. Finally, some IAPs have dual functions as regulators of cell death and cell division. In this chapter, we provide an overview of IAP family proteins, including their structures and domain organizations, biochemical and cellular functions, intracellular locations, post-translational modifications, and relevance to disease.
- Type
- Chapter
- Information
- ApoptosisPhysiology and Pathology, pp. 11 - 22Publisher: Cambridge University PressPrint publication year: 2011